Co-delivery of honokiol, a constituent of Magnolia species, in a self-microemulsifying drug delivery system for improved oral transport of lipophilic sirolimus

References

• Ambudkar SV, Dey S, Hrycyna CA, et al. (1999). Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361–98
   PubMed Web of Science ®Google Scholar
• Anton N, Benoit JP, Saulnier P. (2008). Design and production of nanoparticles formulated from nano-emulsion templates-a review. J Control Release 128:185–99
   PubMed Web of Science ®Google Scholar
• Anuchapreeda S, Leechanachai P, Smith MM, et al. (2002). Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol 64:573–82
   PubMed Web of Science ®Google Scholar
• Avtanski DB, Nagalingam A, Bonner MY, et al. (2014). Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis. Mol Oncol 8:565–80
   PubMed Web of Science ®Google Scholar
• Basalious EB, Shawky N, Badr-Eldin SM. (2010). SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization. Int J Pharm 391:203–11
   PubMed Web of Science ®Google Scholar
• Bouchemal K, Briancon S, Perrier E, Fessi H. (2004). Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int J Pharm 280:241–51
   PubMed Web of Science ®Google Scholar
• Chaudhary PM, Roninson IB. (1993). Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst 85:632–9
   PubMed Web of Science ®Google Scholar
• Collnot EM, Baldes C, Wempe MF, et al. (2006). Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release 111:35–40
   PubMed Web of Science ®Google Scholar
• Cummins CL, Salphati L, Reid MJ, Benet LZ. (2003). In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther 305:306–14
   PubMed Web of Science ®Google Scholar
• Dahan A, Amidon GL. (2009). Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs. 6:19–28
   Google Scholar
• Di YM, Li CG, Xue CC, Zhou SF. (2008). Clinical drugs that interact with St. John's wort and implication in drug development. Curr Pharm Design 14:1723–42
   PubMed Web of Science ®Google Scholar
• Dokania S, Joshi AK. (2014). Self-microemulsifying drug delivery system (SMEDDS) - challenges and road ahead. Drug Deliv. Early Online: 1-16. DOI: 10.3109/10717544.2014.896058
   PubMed Web of Science ®Google Scholar
• Ershov FI, Kas'ianova NV, Vasil'ev AN. (2002). Kaletra (lopinavir/ritonavir) -- a new HIV protease inhibitor. Antibiot Khimioter 47:27–9
   PubMedGoogle Scholar
• Esumi T, Makado G, Zhai H, et al. (2004). Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. Bioorg Med Chem Lett 14:2621–5
   PubMed Web of Science ®Google Scholar
• Friche E, Jensen PB, Sehested M, et al. (1990). The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor. Cancer Commun 2:297–303
   PubMed Web of Science ®Google Scholar
• Gaylord G. (1999). New Norvir soft-gel capsule formulation approved by FDA. Posit Living 8:11
   PubMedGoogle Scholar
• Gershanik T, Benita S. (2000). Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 50:179–88
   PubMed Web of Science ®Google Scholar
• Gursoy N, Garrigue JS, Razafindratsita A, et al. (2003). Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system. J Pharm Sci 92:2411–18
   PubMed Web of Science ®Google Scholar
• Gursoy RN, Benita S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 58:173–82
   PubMed Web of Science ®Google Scholar
• Herzog CE, Tsokos M, Bates SE, Fojo AT. (1993). Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists. J Biol Chem 268:2946–52
   PubMed Web of Science ®Google Scholar
• Hintzen F, Perera G, Hauptstein S, et al. (2014). In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin. Int J Pharm 472:20–6
   PubMed Web of Science ®Google Scholar
• Houghton P, Fang R, Techatanawat I, et al. (2007). The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity. Methods 42:377–87
   PubMed Web of Science ®Google Scholar
• Juliano C, Cossu M, Alamanni MC, Piu L. (2005). Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int J Pharm 299:146–54
   PubMed Web of Science ®Google Scholar
• Kang BK, Lee JS, Chon SK, et al. (2004). Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 274:65–73
   PubMed Web of Science ®Google Scholar
• Lei Y, Qi J, Nie S, et al. (2012). Solid self-nanoemulsifying cyclosporine A pellets prepared by fluid-bed coating: stability and bioavailability study. J Biomed Nanotechnol 8:515–21
   PubMed Web of Science ®Google Scholar
• Li W, Wang Q, Su Q, et al. (2014). Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling. Mol Cells 37:383–8
   PubMed Web of Science ®Google Scholar
• Li X, Yuan Q, Huang Y, et al. (2010). Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech 11:672–8
   PubMed Web of Science ®Google Scholar
• Limtrakul P, Anuchapreeda S, Buddhasukh D. (2004). Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. BMC Cancer 4:13
   PubMed Web of Science ®Google Scholar
• Lin JH, Yamazaki M. (2003). Clinical relevance of P-glycoprotein in drug therapy. Drug Metab Rev 35:417–54
   PubMed Web of Science ®Google Scholar
• Lundin PD, Bojrup M, Ljusberg-Wahren H, et al. (1997). Enhancing effects of monohexanoin and two other medium-chain glyceride vehicles on intestinal absorption of desmopressin (dDAVP). J Pharmacol Exp Ther 282:585–90
   PubMed Web of Science ®Google Scholar
• Patel SSP, Patel NM, Patel MM. (2010). A self-microemulsifying drug delivery system (SMEDDS). Int J Pharm Sci Res 4:29–35
   Google Scholar
• Ma L, Chen J, Wang X, et al. (2011). Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. J Med Chem 54:6469–81
   PubMed Web of Science ®Google Scholar
• Mekjaruskul C, Yang YT, Leed MG, et al. (2013). Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-beta-cyclodextrin. Int J Pharm 445:1–11
   PubMed Web of Science ®Google Scholar
• Mu L, Elbayoumi TA, Torchilin VP. (2005). Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and d-alpha-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin. Int J Pharm 306:142–9
   PubMed Web of Science ®Google Scholar
• Muller C, Bailly JD, Goubin F, et al. (1994). Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines. Int J Cancer 56:749–54
   PubMed Web of Science ®Google Scholar
• Pouton CW, Porter CJ. (2008). Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv Drug Deliv Rev 60:625–37
   PubMed Web of Science ®Google Scholar
• Rege BD, Kao JP, Polli JE. (2002). Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur J Pharm Sci 16:237–46
   PubMed Web of Science ®Google Scholar
• Sachan KK, Kasture SB. (2010). Self-emulsifying drug delivery system a novel approach for enhancement of bioavailability. Int J Pharm Tech Res 2:1738–45
   Google Scholar
• Sonneveld P, Wiemer E. (1997). Inhibitors of multidrug resistance. Curr Opin Oncol 9:543–8
   PubMedGoogle Scholar
• Sun M, Zhai X, Xue K, et al. (2011). Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with oral bioavailabilities in rats. Eur J Pharm Sci 43:132–40
   PubMed Web of Science ®Google Scholar
• Tsai SK, Huang CH, Huang SS, et al. (1999). Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: influence of L-NAME and aspirin. Pharmacology 59:227–33
   PubMed Web of Science ®Google Scholar
• Wahlang B, Pawar YB, Bansal AK. (2011). Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model. Eur J Pharm Biopharm 77:275–82
   PubMed Web of Science ®Google Scholar
• Xu D, Lu Q, Hu X. (2006). Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol. Cancer Lett 243:274–80
   PubMed Web of Science ®Google Scholar
• Yamagata T, Kusuhara H, Morishita M, et al. (2007). Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release 124:1–5
   PubMed Web of Science ®Google Scholar
• Yee S. (1997). In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man- fact or myth. Pharm Res 14:763–6
   PubMed Web of Science ®Google Scholar
• Yin YM, Cui FD, Mu CF, et al. (2009). Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation. J Control Release 140:86–94
   PubMed Web of Science ®Google Scholar
• Yoo JH, Shanmugam S, Thapa P, et al. (2010). Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein. Arch Pharmacal Res 33:417–26
   PubMed Web of Science ®Google Scholar
• Zeng Z, Zhou G, Wang X, et al. (2010). Preparation, characterization and relative bioavailability of oral elemene o/w microemulsion. Int J Nanomed 5:567–72
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li X, Zhou Y, et al. (2010). Cyclosporin A-loaded poly(ethylene glycol)-b-poly(d,l-lactic acid) micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Mol Pharm 7:1169–82
   PubMed Web of Science ®Google Scholar
• Zhang Z, Chen Y, Deng J, et al. (2014). Solid dispersion of berberine-phospholipid complex/TPGS 1000/SiO(2): preparation, characterization and in vivo studies. Int J Pharm 465:306–16
   PubMed Web of Science ®Google Scholar
• Zhao C, Liu ZQ. (2011). Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA. Biochimie 93:1755–60
   PubMed Web of Science ®Google Scholar