4,365
Views
97
CrossRef citations to date
0
Altmetric
Research Article

Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment

, , , &
Pages 2608-2616 | Received 26 Feb 2015, Accepted 07 Apr 2015, Published online: 02 Jun 2015

References

  • Abu-Khalaf M. (2014). A study of the mTOR inhibitor rapamycin (Rapamune, Sirolimus) in combination with abraxane in advanced solid cancers [online]. National Institute of Health, US. Available from: http://clinicaltrials.gov/show/NCT00337376 [last accessed 11 Oct 2014]
  • Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM. (2003). P-glycoprotein: from genomics to mechanism. Oncogene 22:7468–85
  • Bezerra DP, Castro FO, Alves A, et al. (2006). In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Braz J Med Biol Res 39:801–7
  • Bhardwaj RK, Glaeser H, Becquemont L, et al. (2002). Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 302:645–50
  • Borst P, Zelcer N, Van de Wetering K, Poolman B. (2006). On the putative co-transport of drugs by multidrug resistance proteins. FEBS Lett 580:1085–93
  • Chang J, Jallouli Y, Kroubi M, et al. (2009). Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood brain barrier. Int J Pharm 379:285–92
  • Chen Y, Brill GM, Benz NJ, et al. (2007). Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for rapamycin analog ABT-578: application to active pharmaceutical ingredient process development. J Chromatogr B 858:106–17
  • Chen Y, Zheng Y, Foster DA. (2003). Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene 22:3937–42
  • Chorny M, Fishbein I, Danenberg HD, Golomb G. (2002). Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J Control Release 83:389–400
  • Cornaire G, Woodley J, Hermann P, et al. (2004). Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. Int J Pharm 278:119–31
  • Das S, Haddadi A, Veniamin S, Samuel J. (2008). Delivery of rapamycin-loaded nanoparticle down regulates ICAM-1 expression and maintains an immunosuppressive profile in human CD34+ progenitor-derived dendritic cells. J Biomed Mater Res A 85:983–92
  • Elsheikh MA, Elnaggar YSR, Abdallah OY. (2014). Rationale employment of cell culture versus conventional techniques in pharmaceutical appraisal of nanocarriers. J Control Release 194:92–102
  • Farah S, Khan W, Domb AJ. (2013). Crystalline coating of rapamycin onto a stent: process development and characterization. Int J Pharm 445:20–8
  • Ganta S, Amiji M. (2009). Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol Pharm 6:928–39
  • Haddadi A, Elamanchili P, Lavasanifar A, et al. (2008). Delivery of rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells. J Biomed Mater Res A 84:885–98
  • Hariharan S, Elamanchili P, Lavasanifar A, et al. (2006). Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy. Pharma Res 23:184–95
  • Ho EA, Soo PL, Allen C, Piquette-Miller M. (2007). Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors. J Control Release 117:20–7
  • Hoffman A, Domb AJ, Elgart A, Cherniakov I. (2013). Formulation and method for increasing oral bioavailability of drugs. PCT/IL2013/050047
  • Khan W, Farah S, Nyska A, Domb AJ. (2013). Carrier free rapamycin loaded drug eluting stent: in vitro and in vivo evaluation. J Control Release 168:70–6
  • Mainardes RM, Evangelista RC. (2005). PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. Int J Pharm 290:137–44
  • Naseerali CP, Hari PR, Sreenivasan K. (2010). The release kinetics of drug eluting stents containing sirolimus as coated drug: role of release media. J Chromatogr B 878:709–12
  • Nelson FC, Stachel SJ, Eng CP, Sehgal SN. (1999). Manipulation of the C (22)–C (27) region of rapamycin: stability issues and biological implications. Bioorg Med Chem Lett 9:295–300
  • Nieto Montesinos R, Beduneau A, Pellequer Y, Lamprecht A. (2012). Delivery of P-glycoprotein substrates using chemosensitizers and nanotechnology for selective and efficient therapeutic outcomes. J Control Release 161:50–61
  • Noh W-C, Mondesire WH, Peng J, et al. (2004). Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 10:1013–23
  • Panyam J, Dali MM, Sahoo SK, et al. (2003). Polymer degradation and in vitro release of a model protein from poly(d,l-lactide-co-glycolide) nano-and microparticles. J Control Release 92:173–87
  • Patil Y, Sadhukha T, Ma L, Panyam J. (2009). Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance. J Control Release 136:21–9
  • Quintanar-Guerrero D, Allemann E, Fessi H, Doelker E. (1998). Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Dev Ind Pharm 24:1113–28
  • Rao JP, Geckeler KE. (2011). Polymer nanoparticles: preparation techniques and size-control parameters. Prog Polym Sci 36:887–913
  • Sahoo SK, Labhasetwar V. (2005). Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. Mol Pharma 2:373–83
  • Sasaki I, Tanaka K, Fujita T, et al. (1995). Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. II. In situ and in vitro absorption characteristics of azetirelin from the rat intestine. Bio Pharma Bull 18:976–9
  • Schubert S, Delaney Jr JT, Schubert US. (2011). Nanoprecipitation and nanoformulation of polymers: from history to powerful possibilities beyond poly (lactic acid). Soft Matter 7:1581–8
  • Seto B. (2012). Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer. Clin Transl Med 1:1–7
  • Sha X, Fang X. (2004). Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs. Int J Pharm 272:161–71
  • Shaikh J, Ankola DD, Beniwal V, et al. (2009). Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 37:223–30
  • Shoba G, Joy D, Joseph T, et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64:353–6
  • Simamora P, Alvarez JM, Yalkowsky SH. (2001). Solubilization of rapamycin. Int J Pharm 213:25–9
  • Song XR, Cai Z, Zheng Y, et al. (2009). Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticles. Eur J Pharma Sci 37:300–5
  • Vijayakumar RS, Surya D, Nalini N. (2004). Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep 9:105–10
  • Yatscoff RW, Boeckx R, Holt DW, et al. (1995). Consensus guidelines for therapeutic drug monitoring of rapamycin: report of the consensus panel. Ther Drug Monit 17:676–80
  • Yellen P, Saqcena M, Salloum D, et al. (2011). High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle 10:3948–56

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.