1,549
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and tissue distribution study of 16-dehydropregnenolone liposome in female mice after intravenous administration

, , , , , & show all
Pages 2787-2795 | Received 17 Jun 2015, Accepted 26 Aug 2015, Published online: 14 Sep 2015

References

  • Akhter A, Hayashi Y, Sakurai Y, et al. (2013). A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence. Int J Pharm 456:195–201
  • Arpicco S, Lerda C, Pozza ED, et al. (2013). Hyaluronic acid-coated liposomes for active targeting of gemcitabine. Eur J Pharm Biopharm 85:373–80
  • Awasthi VD, Garcia D, Goins BA, Phillips WT. (2003). Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits. Int J Pharm 253:121–32
  • Bradley AJ, Devine DV, Ansell SM, et al. (1988). Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol)-lipids. Arch Biochem Biophys 357:185–94
  • Deng ZX, Zhang S, Xie YT, et al. (2015). Preparation and quality evaluation of lyophilized 16-dehydropregnenolone liposome. Herald Med 34:365–70
  • Guchelaar GH. (2012). Liposomal drug formulations in cancer therapy: 15 years along the road. Drug Discov Today 17:160–6
  • Huang AW, Su ZG, Li S, et al. (2014). Oral absorption enhancement of salmon calcitonin by using both N-trimethyl chitosan chloride and oligoarginines-modified liposomes as the carriers. Drug Deliv 21:388–96
  • Immordino ML, Brusa P, Arpicco S, et al. (2003). Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel. J Control Release 91:417–29
  • Jia L, Garza M, Wong H, et al. (2002). Pharmacokinetic comparison of intravenous carbendazim and remote loaded carbendazim liposomes in nude mice. J Pharm Biomed Anal 28:65–72
  • Kobayashi Y, Tagawa N, Saiki K, Watanabe F. (1994). Studies on steroids in fetuses and neonates: identification of 16-dehydropregnenolone in the circulation of pre-term neonates. Biol Pharm Bull 17:1501–4
  • Kumar D, Khanna AK, Pratap R, et al. (2012). Dose escalation pharmacokinetics and lipid lowering activity of a novel farnesoid X receptor modulator: 16-dehydropregnenolone. Indian J Pharmacol 44:57–62
  • Li Y, Zhang Y, Yang T, et al. (2015). Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS. J Chromatogr B 991:13–20
  • Ling YZ, Li JS, Kateuya K, et al. (1998). Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/C17,20-lyase and 5α-reductase. Bioorg Med Chem Lett 6:1683–93
  • Ma B, Li XT, Li J, et al. (2014). Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LC–MS/MS: application to pharmacokinetic and tissue distribution study. J Pharm Biomed Anal 88:191–200
  • Ma EL, Zhao DM, Li YC, et al. (2012). Activation of ATM–Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosis in HeLa cells. J Asian Nat Prod Res 14:1–9
  • Minko T, Pakunlu RI, Wang Y, et al. (2006). New generation of liposomal drugs for cancer. Anticancer Agents Med Chem 6:537–52
  • Phan G, Herbet A, Cholet S, et al. (2005). Pharmacokinetics of DTPA entrapped in conventional and long-circulating liposomes of different size for plutonium decorporation. J Control Release 110:177–88
  • Pratap R, Gupta RC, Chander R, et al. (2005). U.S. Patent No. 6,875,758. Washington, DC: U.S. Patent and Trademark Office
  • Qin Z, Deng ZX, Liu X, et al. (2015). Study on antitumor effect of 16-dehydropregnenolone liposomes. Chin J Pharm, in press
  • Robert ES, Denise CY, Mark AR, Vincent HLL. (1983). Effects of topically applied liposomes on disposition of epinephrine and insulin in the albino rabbit eye. Int J Pharm 13:263–72
  • Sadzuka Y, Hirotsu S, Hirota S. (1998). Effect of liposomaliazation on the antitumaor activity, side-effects and tissue distribution of CPT-11. Cancer Lett 127:99–106
  • Shi S, Chen H, Lin X, Tang X. (2010). Pharmacokinetics, tissue distribution and safety of cinnarizine delivered in lipid emulsion. Int J Pharm 383:264–70
  • Singh SK, Mehrotra N, Sabarinath S, Gupta RC. (2003). HPLC-UV method development and validation for 16-dehydropregnenolone, a novel oral hypolipidaemic agent, in rat biological matrices for application to pharmacokinetic studies. J Pharm Biomed Anal 33:755–64
  • Sun LX, Fu WW, Ren J, et al. (2006). Cytotoxic constituents from Solanum lyratum. Arch Pharm Res 29:135–9
  • Suryawanshi S, Singh SK, Gupta RC. (2006). A sensitive and selective HPLC/ESI-MS/MS assay for the simultaneous quantification of 16-dehydropregnenolone and its major metabolites in rabbit plasma. J Chromatogr B 830:54–63
  • Suryawanshi S, Wahajuddin, Gupta RC, Singh SK. (2011). Preclinical pharmacokinetics, dose proportionality, gender difference and protein binding study of 16-dehydropregnenolone, an antihyperlipidemic agent, in rats. J Pharm Pharmacol 63:41–8
  • Szebeni J, Baranyi L, Savay S, et al. (2000). Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction. Am J Physiol 279:1319–28
  • Tian JL, Wang L, Wang L, Ke X. (2014). A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. Drug Deliv 21:553–9
  • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research and Center for Veterinary Medicine. (2001). Guidance for industry: bioanalytical method validation. Available from: http://www/fda.gov/cder/guidance/index.htm [last accessed 18 Apr 2015]
  • Yang HY, Zhang WW, Yang WW, et al. (2011). Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats. J Pharm Anal 1:135–8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.