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Research Article

Synthesis of a novel PEGDGA-coated hPAMAM complex as an efficient and biocompatible gene delivery vector: an in vitro and in vivo study

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Pages 2956-2969 | Received 26 Oct 2015, Accepted 14 Dec 2015, Published online: 05 Aug 2016

References

  • Bai CZ, Choi S, Nam K, et al. (2013). Arginine modified PAMAM dendrimer for interferon beta gene delivery to malignant glioma. Int J Pharm 445:79–87
  • Bi X, Amie Luckanagul J, Allen A, et al. (2015). Synthesis of PAMAM dendrimer-based fast cross-linking hydrogel for biofabrication. J Biomater Sci Polym Ed 26:669–82
  • Bielinska AU, Chen C, Johnson J, Baker JR Jr. (1999). DNA complexing with polyamidoamine dendrimers: implications for transfection. Bioconjug Chem 10:843–50
  • Boussif O, Lezoualc’h F, Zanta MA, et al. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 92:7297–301
  • Cao L, Yang W, Wang C, Fu S. (2007). Synthesis and striking fluorescence properties of hyperbranched poly(amido amine). J Macromol Sci A 44:417–24
  • Carrabino S, Di Gioia S, Copreni E, Conese M. (2005). Serum albumin enhances polyethylenimine-mediated gene delivery to human respiratory epithelial cells. J Gene Med 7:1555–64
  • Choi S, Baudys M, Kim SW. (2004b). Control of blood glucose by novel GLP-1 delivery using biodegradable triblock copolymer of PLGA-PEG-PLGA in type 2 diabetic rats. Pharm Res 21:827–31
  • Choi YJ, Kang SJ, Kim YJ, et al. (2010). Comparative studies on the genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine (PEI) and polyamidoamine (PAMAM) dendrimer in Jurkat T-cells. Drug Chem Toxicol 33:357–66
  • Choi JS, Nam K, Park JY, et al. (2004a). Enhanced transfection efficiency of PAMAM dendrimer by surface modification with l-arginine. J Control Release 99:445–56
  • Crystal RG. (1995). Transfer of genes to humans: early lessons and obstacles to success. Science 270:404–10
  • Curto KA, Sweeney WE, Avner ED, et al. (1988). Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. J Histochem Cytochem 36:159–66
  • Deng J, Wen Y, Wang C, et al. (2011). Efficient intracellular gene delivery using the formulation composed of poly (l-glutamic acid) grafted polyethylenimine and histone. Pharm Res 28:812–26
  • Dufès C, Uchegbu IF, Schätzlein AG. (2005). Dendrimers in gene delivery. Adv Drug Deliv Rev 57:2177–202
  • Fant K, Esbjorner EK, Lincoln P, Norden B. (2008). DNA condensation by PAMAM dendrimers: self-assembly characteristics and effect on transcription. Biochemistry 47:1732–40
  • Gao Y, Gao G, He Y, et al. (2008). Recent advances of dendrimers in delivery of genes and drugs. Mini Rev Med Chem 8:889–900
  • Haensler J, Szoka FC Jr. (1993). Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 4:372–9
  • Han J, Zheng Y, Zheng S, et al. (2014). Water soluble octa-functionalized POSS: all-click chemistry synthesis and efficient host-guest encapsulation. Chem Commun 50:8712–14
  • Hemmati M, Kazemi B, Najafi F, et al. (2016). Synthesis and evaluation of a glutamic acid-modified hPAMAM complex as a promising versatile gene carrier. J Drug Target 24:408–21
  • Huang R, Ke W, Han L, et al. (2011). Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration. Biomaterials 32:2399–406
  • Huang R, Liu S, Shao K, et al. (2010). Evaluation and mechanism studies of PEGylated dendrigraft poly-l-lysines as novel gene delivery vectors. Nanotechnology 21:265101
  • Jevprasesphant R, Penny J, Jalal R, et al. (2003). The influence of surface modification on the cytotoxicity of PAMAM dendrimers. Int J Pharm 252:263–6
  • Ke W, Shao K, Huang R, et al. (2009). Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials 30:6976–85
  • Kim TI, Seo HJ, Choi JS, et al. (2004). PAMAM-PEG-PAMAM: novel triblock copolymer as a biocompatible and efficient gene delivery carrier. Biomacromolecules 5:2487–92
  • Kommareddy S, Amiji M. (2007). Antiangiogenic gene therapy with systemically administered sFlt-1 plasmid DNA in engineered gelatin-based nanovectors. Cancer Gene Ther 14:488–98
  • Kono K, Akiyama H, Takahashi T, et al. (2005). Transfection activity of polyamidoamine dendrimers having hydrophobic amino acid residues in the periphery. Bioconjug Chem 16:208–14
  • Kukowska-Latallo JF, Bielinska AU, Johnson J, et al. (1996). Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc Natl Acad Sci USA 93:4897–902
  • Kukowska-Latallo JF, Candido KA, Cao Z, et al. (2005). Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res 65:5317–24
  • Kumar A, Yellepeddi VK, Davies GE, et al. (2010). Enhanced gene transfection efficiency by polyamidoamine (PAMAM) dendrimers modified with ornithine residues. Int J Pharm 392:294–303
  • Ma K, Hu MX, Qi Y, et al. (2009). PAMAM-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity. Biomaterials 30:6109–18
  • Mazda O. (2002). Improvement of nonviral gene therapy by Epstein-Barr virus (EBV)-based plasmid vectors. Curr Gene Ther 2:379–92
  • Meister A. (1983). Selective modification of glutathione metabolism. Science 220:472–7
  • Meister A, Anderson ME. (1983). Glutathione. Annu Rev Biochem 52:711–60
  • Orlowski M, Sessa G, Green JP. (1974). Gamma-glutamyl transpeptidase in brain capillaries: possible site of a blood–brain barrier for amino acids. Science 184:66–8
  • Pack DW, Hoffman AS, Pun S, Stayton PS. (2005). Design and development of polymers for gene delivery. Nat Rev Drug Discov 4:581–93
  • Pardridge WM. (2005). Tyrosine hydroxylase replacement in experimental Parkinson’s disease with transvascular gene therapy. NeuroRx 2:129–38
  • Park TG, Jeong JH, Kim SW. (2006). Current status of polymeric gene delivery systems. Adv Drug Deliv Rev 58:467–86
  • Piao L, Li H, Teng L, et al. (2013). Human serum albumin-coated lipid nanoparticles for delivery of siRNA to breast cancer. Nanomed Nanotechnol Biol Med 9:122–9
  • Rejman J, Oberle V, Zuhorn IS, Hoekstra D. (2004). Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J 377:159–69
  • Roessler BJ, Bielinska AU, Janczak K, et al. (2001). Substituted beta-cyclodextrins interact with PAMAM dendrimer-DNA complexes and modify transfection efficiency. Biochem Biophys Res Commun 283:124–9
  • Schmidt M, Voelker HU, Kapp M, et al. (2008). Expression of VEGFR-1 (Flt-1) in breast cancer is associated with VEGF expression and with node-negative tumour stage. Anticancer Res 28:1719–24
  • Seidlitz EP, Sharma MK, Saikali Z, et al. (2009). Cancer cell lines release glutamate into the extracellular environment. Clin Exp Metastasis 26:781–7
  • Speyer CL, Hachem AH, Assi AA, et al. (2014). Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. PLoS One 9:e88830
  • Speyer CL, Smith JS, Banda M, et al. (2012). Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. Breast Cancer Res Treat 132:565–73
  • Takakura Y, Nishikawa M, Yamashita F, Hashida M. (2002). Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery. J Drug Target 10:99–104
  • Tang MX, Redemann CT, Szoka FC Jr. (1996). In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 7:703–14
  • Tang MX, Szoka, FC. (1997). The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 4:10
  • Thomas CE, Ehrhardt A, Kay MA. (2003). Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 4:346–58
  • Thomas M, Ge Q, Lu JJ, et al. (2005). Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharm Res 22:373–80
  • Tian H, Xiong W, Wei J, et al. (2007). Gene transfection of hyperbranched PEI grafted by hydrophobic amino acid segment PBLG. Biomaterials 28:2899–907
  • Tomalia DA. (2005). Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Progr Polym Sci 30:294–324
  • Twyman LJ, King AS, Burnett J, Martin IK. (2004). Synthesis of aromatic hyperbranched PAMAM polymers. Tetrahedr Lett 45:433–5
  • Vina JR, Palacin M, Puertes IR, et al. (1989). Role of the gamma-glutamyl cycle in the regulation of amino acid translocation. Am J Physiol 257:E916–22
  • Wang Y, Chang YC. (2003). Synthesis and conformational transition of surface-tethered polypeptide:  poly(l-lysine). Macromolecules 36:6511–18
  • Wang X, He Y, Wu J, et al. (2010). Synthesis and evaluation of phenylalanine-modified hyperbranched poly(amido amine)s as promising gene carriers. Biomacromolecules 11:245–51
  • Wen Y, Pan S, Luo X, et al. (2009). A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector. Bioconjug Chem 20:322–32
  • Xiong MP, Forrest ML, Ton G, et al. (2007). Poly(aspartate-g-PEI800), a polyethylenimine analogue of low toxicity and high transfection efficiency for gene delivery. Biomaterials 28:4889–900
  • Yang K, Qin W, Tang H, et al. (2011). Polyamidoamine dendrimer-functionalized carbon nanotubes-mediated GFP gene transfection for HeLa cells: effects of different types of carbon nanotubes. J Biomed Mater Res A 99:231–9
  • Ye L, Haider H, Tan R, et al. (2007). Transplantation of nanoparticle transfected skeletal myoblasts overexpressing vascular endothelial growth factor-165 for cardiac repair. Circulation 116:I113–20
  • Zeng X, Pan S, Li J, et al. (2011). A novel dendrimer based on poly (l-glutamic acid) derivatives as an efficient and biocompatible gene delivery vector. Nanotechnology 22:375102
  • Zheng Y, Li S, Weng Z, Gao C. (2015). Hyperbranched polymers: advances from synthesis to applications. Chem Soc Rev 44:4091–130
  • Zhu K, Guo C, Lai H, et al. (2012). Novel hyperbranched polyamidoamine nanoparticle based gene delivery: transfection, cytotoxicity and in vitro evaluation. Int J Pharm 423:378–83
  • Zhu S, Hong M, Tang G, et al. (2010). Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style. Biomaterials 31:1360–71
  • Zinselmeyer BH, Mackay SP, Schatzlein AG, Uchegbu IF. (2002). The lower-generation polypropylenimine dendrimers are effective gene-transfer agents. Pharm Res 19:960–7

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