Improved oral efficacy of epirubicin through polymeric nanoparticles: pharmacodynamic and toxicological investigations

References

• Akhtar N, Talegaonkar S, Khar RK, Jaggi M. (2013). Self-nanoemulsifying lipid carrier system for enhancement of oral bioavailability of etoposide by P-glycoprotein modulation: in vitro cell line and in vivo pharmacokinetic investigation. J Biomed Nanotechnol 9:1216–29
   PubMed Web of Science ®Google Scholar
• Araujo L, Sheppard M, Löbenberg R, Kreuter J. (1999). Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: modification of the body distribution after suspension in surfactant solutions and in oil vehicles. Int J Pharm 176:209–24
   Web of Science ®Google Scholar
• Astete CE, Sabliov CM. (2006). Synthesis and characterization of PLGA nanoparticles. J Biomater Sci Polym Ed 17:247–89
   PubMed Web of Science ®Google Scholar
• Bhardwaj V, Ankola DD, Gupta SC, et al. (2009). PLGA nanoparticles stabilized with cationic surfactant: safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat. Pharm Res 26:2495–503
   PubMed Web of Science ®Google Scholar
• Claiborne A. (1985). Catalase activity. In: RA, G. ed. Handbook of methods for oxygene radical research. Boca Raton (FL): CRC Press. p 283–4
   Google Scholar
• Fatma S, Talegaonkar S, Iqbal Z, et al. (2014). Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations. Drug Deliv 21:1–12
   PubMed Web of Science ®Google Scholar
• Galindo-Rodriguez SA, Allemann E, Fessi H, Doelker E. (2005). Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies. Crit Rev Ther Drug Carrier Syst 22:419–64
   PubMed Web of Science ®Google Scholar
• Golla K, Reddy PS, Bhaskar C, Kondapi AK. (2013). Biocompatibility, absorption and safety of protein nanoparticle-based delivery of doxorubicin through oral administration in rats. Drug Deliv 20:156–67
   PubMed Web of Science ®Google Scholar
• Harada M, Bobe I, Saito H, et al. (2011). Improved anti-tumor activity of stabilized anthracycline polymeric micelle formulation, NC-6300. Cancer Sci 102:192–9
   PubMed Web of Science ®Google Scholar
• He C, Yin L, Tang C, Yin C. (2012). Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs. Biomaterials 33:8569–78
   PubMed Web of Science ®Google Scholar
• Householder KT, Diperna DM, Chung EP, et al. (2015). Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. Int J Pharm 479:374–80
   PubMed Web of Science ®Google Scholar
• Jain AK, Swarnakar NK, Das M, et al. (2011a). Augmented anticancer efficacy of doxorubicin-loaded polymeric nanoparticles after oral administration in a breast cancer induced animal model. Mol Pharm 8:1140–51
   PubMed Web of Science ®Google Scholar
• Jain AK, Swarnakar NK, Das M, et al. (2011b). The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen. Biomaterials 32:503–15
   PubMed Web of Science ®Google Scholar
• Jain S, Patil SR, Swarnakar NK, Agrawal AK. (2012). Oral delivery of doxorubicin using novel polyelectrolyte-stabilized liposomes (layersomes). Mol Pharm 9:2626–35
   PubMed Web of Science ®Google Scholar
• Joshi G, Kumar A, Sawant K. (2014). Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. Eur J Pharm Sci 60:80–9
   PubMed Web of Science ®Google Scholar
• Kalaria DR, Sharma G, Beniwal V, Ravi Kumar MN. (2009). Design of biodegradable nanoparticles for oral delivery of doxorubicin: in vivo pharmacokinetics and toxicity studies in rats. Pharm Res 26:492–501
   PubMed Web of Science ®Google Scholar
• Katiyar SS, Muntimadugu E, Rafeeqi TA, et al. (2015). Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment. Drug Deliv 3:1–9
   Web of Science ®Google Scholar
• Ke W, Zhao Y, Huang R, et al. (2008). Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system. J Pharm Sci 97:2208–16
   PubMed Web of Science ®Google Scholar
• Khuroo T, Verma D, Talegaonkar S, et al. (2014). Topotecan-tamoxifen duple PLGA polymeric nanoparticles: investigation of in vitro, in vivo and cellular uptake potential. Int J Pharm 473:384–94
   PubMed Web of Science ®Google Scholar
• Kulkarni SA, Feng SS. (2011). Effects of surface modification on delivery efficiency of biodegradable nanoparticles across the blood-brain barrier. Nanomedicine (Lond) 6:377–94
   PubMed Web of Science ®Google Scholar
• Lalatsa A, Garrett NL, Ferrarelli T, et al. (2012). Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles. Mol Pharm 9:1764–74
   PubMed Web of Science ®Google Scholar
• Lale SV, Kumar A, Naz F, et al. (2015). Multifunctional ATRP based pH responsive polymeric nanoparticles for improved doxorubicin chemotherapy in breast cancer by proton sponge effect/endo-lysosomal escape. Polym Chem 6:2115–32
   Web of Science ®Google Scholar
• Li L, Gao FP, Tang HB, et al. (2010). Self-assembled nanoparticles of cholesterol-conjugated carboxymethyl curdlan as a novel carrier of epirubicin. Nanotechnol 21:265601
   PubMed Web of Science ®Google Scholar
• Maeda H. (1992). The tumor blood vessel as an ideal target for macromolecular anticancer agents. J Control Release 19:315–24
   Google Scholar
• Mamot C, Drummond DC, Noble CO, et al. (2005). Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. Cancer Res 65:11631–8
   PubMed Web of Science ®Google Scholar
• Marklund S, Marklund G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469–74
   PubMedGoogle Scholar
• Negi LM, Talegaonkar S, Jaggi M, et al. (2014). Surface engineered nanostructured lipid carriers for targeting MDR tumor: Part II. In vivo biodistribution, pharmacodynamic and hematological toxicity studies. Colloids Surf B Biointerfaces 123:610–15
   PubMed Web of Science ®Google Scholar
• Negi LM, Tariq M, Talegaonkar S. (2013). Nano scale self-emulsifying oil based carrier system for improved oral bioavailability of camptothecin derivative by P-Glycoprotein modulation. Colloids Surf B Biointerfaces 111:346–53
   PubMed Web of Science ®Google Scholar
• Nelson DR. (2011). Progress in tracing the evolutionary paths of cytochrome P450. Biochim Biophys Acta 1814:14–18
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–8
   PubMed Web of Science ®Google Scholar
• Ormrod D, Holm K, Goa K, Spencer C. (1999). Epirubicin: a review of its efficacy as adjuvant therapy and in the treatment of metastatic disease in breast cancer. Drugs Aging 15:389–416
   PubMed Web of Science ®Google Scholar
• Peltier S, Oger JM, Lagarce F, et al. (2006). Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules. Pharm Res 23:1243–50
   PubMed Web of Science ®Google Scholar
• Plosker GL, Faulds D. (1993). Epirubicin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cancer chemotherapy. Drugs 45:788–856
   PubMed Web of Science ®Google Scholar
• Semete B, Booysen L, Kalombo L, et al. (2012). Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration. Int J Pharm 424:115–20
   PubMed Web of Science ®Google Scholar
• Semete B, Booysen L, Lemmer Y, et al. (2010). In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems. Nanomedicine 6:662–71
   PubMed Web of Science ®Google Scholar
• Tariq M, Alam MA, Singh AT, et al. (2015). Biodegradable polymeric nanoparticles for oral delivery of epirubicin: In vitro, ex vivo, and in vivo investigations. Colloids Surf B Biointerfaces 128:448–56
   PubMed Web of Science ®Google Scholar
• Verma P, Meher JG, Asthana S, et al. (2015). Perspectives of nanoemulsion assisted oral delivery of docetaxel for improved chemotherapy of cancer. Drug Deliv 21:1–10
   Google Scholar
• Yang Q, Ma Y, Zhao Y, et al. (2013). Accelerated drug release and clearance of PEGylated epirubicin liposomes following repeated injections: a new challenge for sequential low-dose chemotherapy. Int J Nanomed 8:1257–68
   PubMed Web of Science ®Google Scholar
• Yao HJ, Ju RJ, Wang XX, et al. (2011). The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery. Biomaterials 32:3285–302
   PubMed Web of Science ®Google Scholar
• Yin Y, Chen D, Qiao M, et al. (2007). Lectin-conjugated PLGA nanoparticles loaded with thymopentin: ex vivo bioadhesion and in vivo biodistribution. J Control Release 123:27–38
   PubMed Web of Science ®Google Scholar
• Yuan H, Chen CY, Chai GH, et al. (2013). Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles. Mol Pharm 10:1865–73
   PubMed Web of Science ®Google Scholar
• Zhang HZ, Gao FP, Liu LR, et al. (2009). Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy. Colloids Surf B Biointerfaces 71:19–26
   PubMed Web of Science ®Google Scholar
• Zhang Z, Feng SS. (2006). Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release. Biomaterials 27:262–70
   PubMed Web of Science ®Google Scholar
• Zhao J, Liu CS, Yuan Y, et al. (2007). Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers. Biomaterials 28:1414–22
   PubMed Web of Science ®Google Scholar