13
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Hypoglycemic effect of gelatin microspheres with entrapped insulin and protease inhibitor in normal and diabetic rats

&
Pages 29-38 | Received 19 Jan 1994, Published online: 27 Sep 2008

References

  • Nagai T. Topical mucosal adhesive forms. Med. Res. Rev. 1986; 6: 227–242
  • Moses A. C., Gorden G. S., Carey M. C., Flier J. S. Insulin administered intransally as an insulin-bile salt aerosol: Effectiveness and reproducibility in normal and diabetic subjects. Diabetes 1983; 32: 1040–1047
  • Nishihata T., Okamura Y., Inagaki H., Sudoh M., Kamada A., Yagi T., Kawamori R., Shichiri M. Trial of rectal insulin suppositories in healthy humans. Int. J. Pharm. 1986; 34: 157–161
  • Wigley F. M., Londono J. H., Wood S., Shipp T. C., Waldman R. H. Insulin across respiratory mucosae by aerosol delivery. Diabetes 1971; 20: 552–556
  • Liu J. C., Sun Y., Siddique O., Chien Y. W., Shi W. M., Li J. Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin. Int. J. Pharm. 1988; 44: 197–204
  • Fujii S., Yokohama T., Ikegawa K., Sato F., Yoko N. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J. Pharm. Pharmacol. 1985; 37: 545–549
  • Touitou E., Rubinstein A. Targeted enteral delivery of insulin to rats. Int. J. Pharm. 1986; 30: 95–99
  • Damage C., Michel C., Aprahamian M., Couvreur P. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes 1988; 37: 246–251
  • Kidron M., Bar-On H., Berry E. M., Ziv E. The absorption of insulin from various regions of the rat intestine. Life Sci. 1982; 31: 2837–2841
  • Schilling J. R., Mitra A. K. Intestinal mucosal transport of insulin. Int. J. Pharm. 1990; 62: 53–64
  • Shichiri M., Etani N., Kawamori R., Karasaki K., Okada A., Shigeta Y., Abe H. Absorption of insulin from perfused rabbit small intestine in vitro. Diabetes 1973; 22: 459–465
  • Balsam M. J., Holtzapple P. G., Kaye R., Sewell E. M. Intestinal absorption of insulin in patients with fibrocystic disease. J. Pediatr. 1971; 79: 1011–1014
  • Ziv E., Lior O., Kidron M. Absorption of protein via the intestinal wall: A quantitative model. Biochem. Pharmacol. 1987; 36: 1035
  • Cho Y. W., Flynn M. Oral delivery of insulin. Lancet 1989; ii: 1518–1519
  • Morishita M., Morishita I., Takayama K., Machida Y., Nagai T. Novel oral microspheres of insulin with protease inhibitor protecting from enzymatic degradation. Int. J. Pharm. 1992; 78: 1–7
  • Bodmeier R., Chen H., Paeratakul O. A novel approach to the oral delivery of micro or nanoparticles. Pharm. Res. 1989; 6(5)413–417
  • Murray L. C., Tucker I. G. Gastric residence times of enteric coated dosage forms—A review. Australian J. Hosp. Pharm. 1990; 20(3)235–238
  • Jeyanthi R., Panduranga R. Preparation of gelatin microspheres of bleomycin. Int. J. Pharm. 1987; 35: 177–179
  • Paquot M., Scheen A. J., Franchimont P., Lefebvre P. J. The intra-nasal administration of insulin induces significant hypoglycemic and classical counterregulatory hormonal responses in normal man. Diabetes Metab. 1988; 14: 31–36

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.