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Original Article

Subcutaneous bioavailability of a PRIMATIZEDTM IgG1 Anti-Human CD4 monoclonal antibody is dose dependent in transgenic mice bearing human CD4

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Pages 95-100 | Received 01 Feb 1998, Accepted 17 Feb 1998, Published online: 02 Jul 2009

References

  • Bocci V. Immunology 1988; 64: 1–9
  • Bocci V. Absorption of cytokines via oropharyngeal-associated lymphoid tissues. Clin. Pharmacokinet. 1991; 21: 411–417
  • Davies B., Morris T. Physiological parameters in laboratory animals and humans. Pharm. Res. 1993; 10: 1093–1095
  • Davis C. B., Boyle K. E., Urbanski J. J., Paradysz R. T., Fong K.-L. L. Disposition of metabolically labeled recombinant soluble CD4 (sT4) in male Sprague-Dawley rats following intravenous and subcutaneous administration. Drug Metab. Dispos. 1992; 20: 695–705
  • Davis C. B., Garver E. M., Kwok D. C., Urbanski J. J. Disposition of metabolically radiolabeled CE9.1-a macaque-human chimeric anti-human CD4 monoclonal antibody-in transgenic mice bearing human CD4. Drug Metab. Dispos. 1996; 24: 1032–1037
  • Hamilton R. G., Morrison S. L. Epitope mapping of human immunoglobulin-specific murine monoclonal antibodies with domain-switched deleted and point-mutated chimeric antibodies. J. Immunol. Meth. 1993; 158: 107–122
  • Killeen N., Sawada S., Littman D. R. Regulated expression of human CD4 rescues helper cell development in mice lacking expression of endogenous CD4. EMBO J. 1993; 12: 1547–1553
  • Newman R., Alberts J., Anderson D., Carner K., Heard C., Norton F., Raab R., Reff M., Shuey S., Hanna N. “Primatization” of recombinant antibodies for immunotherapy of human diseases: A macaque-human chimeric antibody against human CD4. Rio/Technology 1992; 10: 1455–1460
  • Rehm S., Zimmerman D., Truneh M. A., Bugelski P. J. 1995, Immunohistochemical characterization of lymphocyte markers in HuCD4+ transgenic, MuCD4 knockout and MuCD4+ Balb/c mice. Abstract from the Society of Toxicologic Pathologists 14th International Symposium, San Diego, CA
  • Supersaxo A., Hein W. R., Steffen H. Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm. Res. 1990; 7: 167–169
  • Weinstein J. N., Parker R. J., Holton O. D., Keenan A. M., Covell D. G., Black C. D. V., Sieber S. M. Lymphatic delivery of monoclonal antibodies: Potential for detection and treatment of lymph node metastases. Cancer Invest. 1985; 3: 85–95
  • Weinstein J. N., Steller M. A., Keenan A. M., Covell D. G., Key M. E., Sieber S. M., Oldman R. K., Hwang K. M., Parker R. J. Monoclonal antibodies in the lymphatics: Selective delivery to lymph node metastases of a solid tumor. Science 1983; 222: 423–426

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