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Drug Delivery Volume 5, 1998 - Issue 3
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Original Article

Treatment of Large Solid Tumors in Mice with Daunomycin-Loaded Sterically Stabilized Liposomes

Pamela L. Golden Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
,
JÖRg Huwyler Department of Research, University Hospital and University Children's Hospital Basel, Switzerland
&
William M. Pardridge Department of Medicine, UCLA School of Medicine, Los Angeles, California, USACorrespondence[email protected]
Pages 207-212 | Received 24 Mar 1998, Accepted 09 Apr 1998, Published online: 02 Jul 2009

References

  • Lasic D. D. Doxorubicin in sterically stabilized liposomes. Nature 1996; 380: 561–562
  • Allen T. M. Long-circulating (sterically stabilized) liposomes for targeted drug delivery. Trends Pharmacol. Sci 1994; 15: 215–220
  • Papahadjopoulos D., Allen T. M., Gabizon A., Mayhew E., Matthay K., Huang S. K., Lee K. D., Woodle M. C., Lasic D. D., Redemann C., Martin F. J. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. USASS 1991; 11460–11464
  • Yuan E., Leunig M., Huang S. K., Berk D. A., Papahadjopoulos D., Jain R. K. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res 1994; 54: 3352–3356
  • Allen T. M., Newman M. S., Woodle M. C., Mayhew E., Uster P. S. Pharmacokinetics and anti-tumor activity of vincristine encapsulated in sterically stabilized liposomes. Int. J. Cancer 1995; 62: 199–204
  • Vaage J., Mayhew E., Lasic D., Martin F. Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes. Int. J. Cancer 1992; 51: 942–948
  • Boucher Y., Baxter L. T., Jain R. K. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implication for therapy. Cancer Res 1990; 50: 4478–4484
  • Jain R. K. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl. Cancer Inst 1989; 81: 570–576
  • Huang S. S., Koh H. A., Konish Y., Bullock L. D., Huang J. S. Differential processing and turnover of the oncogenically activated neu/erb B2 gene product and its normal cellular counterpart. J. Biol. Chem 1990; 265: 3340–3346
  • Harwerth I. M., Wels W., Schlegel J., Müller M., Hynes N. E. Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth. Br. J. Cancer 1993; 68: 1140–1145
  • Mayer L. D., Bally M. B., Cullis P. R. Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. Biochim. Biophys. Acta 1986; 857: 123–126
  • Huwyler J., Wu D., Pardridge W. M. Brain drug delivery of small molecules using immunoliposomes. Proc. Natl. Acad. Sci. USA 1996; 93: 14164–14169
  • Huwyler J., Yang J., Pardridge W. M. Receptor mediated delivery of daunomycin using immunoliposomes: pharmacokinetics and tissue distribution in the rat. J. Pharmacol. Exp. Ther 1997; 282: 1541–1546
  • Busche R., Tümmler B., Cano-Gauci D. F., Riordan J. R. Equilibrium, kinetic and photoaffinity studies of daunomycin binding to P-glycoprotein-containing membranes of multidrug-resistant Chinese hamster ovary cells. Eur. J. Biochem 1989; 183: 189–197
  • Allen T. M., Hansen C. B., Guo L. S. Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection. Biochim. Biophys. Acta 1993; 1150: 9–16
  • Pardridge W. M., Golden P. L., Kang Y S., Bickel U. Brain microvascular and astrocyte localization of P-glycoprotein. J. Neurochem 1997; 68: 1278–1285
  • Paskins-Hurlburt A. J., Hollenberg N. K., Abrams H. L. Tumor perfusion in relation to the rapid growth phase and necrosis: studies on the Walker carcinoma in the rat testicle. Microvasc. Res 1982; 24: 15–24
  • Buzdar A. U., Marcus C., Smith T. L., Blumenschein G. R. Early and delayed cardiotoxicity of doxorubicin. Cancer 1985; 55: 2761–2765
  • Mayer L. D., Dougherty G., Harasym T. O., Bally M. B. The role of tumor-associated macrophages in the delivery of liposomal doxorubicin to solid murine fibrosarcoma tumors. J. Pharmacol. Exp. Ther 1997; 280: 1406–1414
  • Parr M. J., Masin D., Cullis P. R., Bally M. B. Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol). J. Pharmacol. Exp. Ther 1997; 280: 1319–1327
  • Hosoda J., Unezaki S., Maruyama K., Tsuchiya S., Iwatsuru M. Antitumor activity of doxorubicin encapsulated in poly(ethylene glycol)-coated liposomes. Biol. Pharm. Bull 1995; 18: 1234–1237
  • Emanuel N., Kedar E., Bolotin E. M., Smorodinsky N. I., Barenholz Y. Targeted delivery of doxorubicin via sterically stabilized immunoliposomes: pharmacokinetics and biodistribution in tumor-bearing mice. Pharm. Res 1996; 13: 861–868
  • Mayhew E. G., Lasic D., Babbar S., Martin F. J. Pharmacokinetics and antitumor activity of epirubicin encapsulated in long-circulating liposomes incorporating a polyethylene glycol-derivatized phospholipid. Int. J. Cancer 1992; 51: 302–309

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