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Biomaterials, Medical Devices, and Artificial Organs Volume 10, 1982 - Issue 3
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Original Article

Insulin-Albumin Microbeads: An Implantable, Biodegradable System

M. F. A. Goosen Connaught Research Institute, 1755 Steeles Avenue W. Willowdale, Ontario, M2R 3T4
,
Y. F. Leung Connaught Research Institute, 1755 Steeles Avenue W. Willowdale, Ontario, M2R 3T4
,
S. Chou Connaught Research Institute, 1755 Steeles Avenue W. Willowdale, Ontario, M2R 3T4
&
A. M. Sun Connaught Research Institute, 1755 Steeles Avenue W. Willowdale, Ontario, M2R 3T4
Pages 205-218 | Published online: 11 Jul 2009

References

  • Chien Y. W. Methods to Achieve Sustained Drug Delivery. The Physical Approach: Implants. Sustained and Controlled Release Drug Delivery Systems, J. R. Robinson. Marcel Dekker Inc., New York 1978; 211–349
  • Leung Y. F., O'Shea G. M., Goosen M. F.A., Sun A. M. Microencapsulation of crystalline insulin or islets of Langerhans: an insulin diffusion study. Artificial Organs 1982, in press
  • Drugs and the Pharmaceutical Sciences Series, Vol. 3, Microencapsulation, J. R. Nixon. Marcel Dekker Inc., New York 1976
  • Langer R. S., Peppas N. A. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials 1981; 2: 201–214
  • Chang T. M.S. Artificial Cells. Charles C. Thomas, Springfield, Ill. 1972
  • Anderson J. M., Niven H., Pelagalli J., Olanoff L. S., Jones R. D. The Role of the Fibrous Capsule in the Function of Implanted Drug-Polymer Sustained Release Systems, J. Biomed. Mater, Res. 1981; 15: 889–902
  • Lee T. K., Sokoloski T. D., Royer G. P. Serum Albumin Beads: An Injectable. Biodegradable System for the Sustained Release of Drugs, Science 1981; 213: 233–235
  • Hales C. N., Randle P. J. Immunoassay for Insulin with Insulin-Antibody Precipitate. Biochem. J. 1963; 88: 137
  • Sun A. M., Parisius W., Healy G. M., Vacek I., Macmorine H. The Use in Diabetic Rats and Monkeys of Artificial Capillary Units Containing Cultured Islets of Langerhans (Artificial Endocrine Pancreas). Diabetes 1977; 26: 1136–1139
  • Roseman T. J. Silicone Rubber: A Drug-Delivery System for Contraceptive Steroids in Controlled Release of Biologically Active Agents, A. C. Tanquary, R. E. Lacy. Plenum Press, New York 1974; 99–115
  • Ryan D. M. Implanted Tissue-Cages: A Critical Evaluation of their Relevance in Measuring Tissue Concentrations of Antibiotics, Scand. J. Infec. Dis., Suppl. 1978; 13: 58–62
  • Ryan D. M., Mason U. Antibiotic Tissue Levels: Are Tissue Cages Relevant for their Measurements? J. Antimicrob. Chemother 1979; 5: 116–118
  • Mass Transfer Operations, Second Edition, R. E. Treybal. McGraw Hill, New York 1968; 17–18
  • Goosen M. F.A., Leung Y. F., O'Shea G., Chou S., Sun A. M. unpublished results

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