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Biomaterials, Artificial Cells and Artificial Organs Volume 17, 1989 - Issue 5
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Original Article

Preparation and Characterisation of Xanthine Oxidase Immobilised by Microencapsulation in Artificial Cells for the Removal of Hypoxanthine

Thomas M.S. Chang Professor and Director Artificial Cells & Organs Research Centre, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6
Pages 611-616 | Published online: 11 Jul 2009

References

  • Chang T. M.S. Semipermeable microcapsules. Science 1964; 146: 524–526
  • Chang T. M.S. Artificial Cells monograph. Thomas, Springfield, Illinois 1972
  • Chang T. M.S. Methods in the medical applications of immobilized proteins, enzymes and cells. Methods in Enzymology. 1988; 137: 444–457
  • Chang T. M.S., Poznansky M. Semipermeable microcapsules containing catalase for enzyme replacement in actalasemic mice. Nature 1968; 218(5138)242–245
  • Bourget L., Chang T. M.S. Phenylalanine ammonialyase immobilized in microcapsules for the depleture of phenylalanine in plasma in phenylketonuric rat model. Biochim. Siophys. Acta 1986; 883: 432–438
  • Lesch M, Nyhan W. L. Am J. Hed 1964; 36: 561–570
  • Saugstad O. D. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical prodcution. Pediatr Res 1988; 23: 143–50
  • Chang T. M.S. Recycling of NAD(P) by multienzyine system immobilized by microencapsulation in artificial cells. Methods in Enzymology 1987; 136: 67–82
  • Palmour R., Goodyer P., Reade T., Chang T. M.S. Microencapsulated Xanthine Oxidase as Experimental Therapy in Lesch-Nyhan Disease. Lancet 1989, in press

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