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Biomaterials, Artificial Cells and Immobilization Biotechnology Volume 19, 1991 - Issue 4
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Original Article

The Microencapsulation of Cells Within Alginate Poly-L-Lysine Microcapsules Prepared with the Standard Single Step Drop Technique: Histologically Identified Membrane Imperfections and the Associated Graft Rejection

H Wong Artificial Cells and Organs Research Centre Faculty of Medicine, McGill University Montreal, PQ, Canada, H3G 1Y6
&
Tms Chang Artificial Cells and Organs Research Centre Faculty of Medicine, McGill University Montreal, PQ, Canada, H3G 1Y6
Pages 675-686 | Published online: 11 Jul 2009

References

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  • Chang T. M. S. Aqueous semipermeable microcapsules as artificial cells. Ph.D. Thesis, McGill University. 1965
  • Chang T. M. S., McIntosh F. C., Mason S. G. Semipermeable aqueous microcapsules: I. Preparation and properties. Can J Physiol Pharmac. 1966; 44: 115–28
  • Chang T. M. S. Artificial Organs. Springfield, II. Charles C Thomas Publishers, USA 1972
  • Lim F., Sun A. M. Microencapsulated islets as bioartificial endocrine pancreas. Scien. 1980; 210: 908–10
  • Sun A. M., O'Shea G. M., Goosen M. F. A. Injectable microencapsulated islet cells as a bioartificial pancreas. Appl Biochem Biotechn. 1984; 10: 87–99
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  • Dixit V., Gordon V. P., Pappas S. C., Fisher M. M. Increase survival in GalN-FHF rats following intraperitonel implantation of isolated encapsulated hepatocytes. Biomat Art Cells Art O. 1988; 16: 856, abstr
  • Bruni S., Chang T. M. S. Hepatocytes immobilized by microencapsulation in artificial cells: Effects on hyperbilirubinemia in Gunn rats. Biomat Art Cells Art O. 1989; 17: 403–11
  • Dixit V., Darvasi R., Arthur M., Brezina M., Lewin K., Gitnick G. Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes. Hepat. 1990; 12: 1342–49
  • Goosen M. F. A., O'Shea G. M., Gharapetian H. M., Chou S., Sun A. M. Optimization of microencapsulation parameters: Semipermeable microcapsules as a bioartificial pancreas. Biotechnol Bioe. 1985; 27: 146–50
  • Seglen P. O. Preparation of isolated rat liver cells. Methods Cell Bi. 1976; 13: 29–83
  • Sun A. M., Cai Z., Shi Z., Ma F., O'Shea G. M. Microencapsulated hepatoytes: An invitro and in vivo study. Biomat Art Cells Art O. 1987; 15: 483–96
  • Soon-Shiong P., Otterlie M., Skjak-Braek G., Smidsrod O., Heintz R., Lanza R. P., Espevik T. An immunologic basis for the fibrotic reaction to implanted microcapsules. Transpl. 1991; 23: 758–59

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