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Original Article

Use of Finger-Prick Human Blood Samples as a More Convenient Way for in-Vitro Screening of Modified Hemoglobin Blood Substitutes for Complement Activation: a Preliminary Report

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Pages 685-690 | Published online: 11 Jul 2009

References

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  • Feola M., Simoni J., Canizaro P. C. Complement activation and the toxicity of stroma-free hemoglobin solution in primates. Cir. Shock 1988; 52: 275–290
  • Chang T. M.S., Lister C. A screening test of modified hemoglobin blood substitute before clinical use in patients-based on complement activation of human plasma. Int. J. Biomaterials, Artificial Cells and Artificial Organs 1990; 18(5)693–702
  • Chang T. M.S., Lister C. A preclinical screening test for modified hemoglobin to bridge the gap between animal safety studies and use in human. Biomaterials, Artificial Cells and Immobilization Biotechnology 1992; 20(2-4)565–573
  • Chang T. M.S., Lister C. 1993 Screening test for modified hmoglobin blood substitute before use in human. US Patent No. 5 April 6, 1993; 200: 323, (assigned to McGill University)
  • Chang T. M.S., Lister C., Wong L. T., Er S. S. The use of a preclinical screening test based on C3a activation of human plasma in industrial production of o-raffinose polymerized hemoglobin. Abstract, V International Symposium on Blood Substitutes, San Diego 1993
  • Chang T. M.S., Yu W. P. British Provisional Patent Application. 1992 Biodegradable polymer membrane containing hemoglobin for blood substitute. UK September 14, 1992; 9219426: 5

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