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Artificial Cells, Blood Substitutes, and Biotechnology Volume 22, 1994 - Issue 3
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Original Article

Submicron Biodegradable Polymer Membrane Hemoglobin Nanocapsules as Potential Blood Substitutes: A Preliminary Report

W. P. Yu Artificial Cells and Organs Research Centre Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
&
T. M. S. Chang Artificial Cells and Organs Research Centre Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
Pages 889-893 | Published online: 11 Jul 2009

References

  • Hamilton P. B., Hiller A., VanSlyke D. D. Renal effects of hemoglobin infusions in dogs in hemorrhagic shock. J. Exptl. Med. 1947; 86: 477
  • Chang T. M.S. Semipermeable microcapsules. Science 1964; 146(3643)524
  • Chang T. M.S., Macintosh F. C., Mason S. G. Semipermeable aqueous microcapsules: I. Preparation and properties. Can. J. Phvsiol. Pharmacol. 1966; 44: 115–128
  • Chang T. M.S. Artificial Cells. Charles C Thomas, Springfied, IL 1972, Monograph
  • Djordjevich L., Miller I. F. Synthetic erythrocytes from lipid encapsulated hemoglobin. Exp. Hematol. 1980; 8: 584
  • Hunt A. C., Burnette R. R. Neohemocytes. Advances in Blood Substitute Research, R. B. Bolin, R. P. Oeyer, G. J. Nemo. Alan R. Liss, Inc., New York 1983; 59–70
  • Farmer M. C., Rudolph A. S., Vandegriff K. D., Havre M. D., Bayne S. A., Johnson S. A. Liposome-encapsulated hemoglobin: Oxygen binding properties and respiratory function. J. Biomaterials, Artificial Cells and Artificial Oragans 1988; 16: 289–299
  • Tsuchida E., Nishide H., Ohno H. Liposome/heme as a totally synthetic oxygen carrier. J. Biomaterials, Artificial Cells and Artificial Organs 1988; 16: 313–319
  • Blood Substitutes and Oxygen Carriers, T. M.S. Chang. Marcel Dekker, New York 1992
  • Chang T. M.S. Biodegradable semipermeable microcapsules containing enzymes, hormones, vaccines and other biologicals. J.Bioengineering 1976; 1: 25–32
  • Chang T. M.S., Yu W. P. Biodegradable polymer membrane containing hemoglobin as potential blood substitutes. British Priority 1992, Patent Application No. 92194265

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