56
Views
23
CrossRef citations to date
0
Altmetric
Original Article

Enzyme Replacement Therapy in ENU2 Phenylketonuric Mice Using Oral Microencapsulated Phenylalanine Ammonia-Lyase: A Preliminary Report

Pages 681-692 | Published online: 11 Jul 2009

References

  • Chang T. M.S., Bourget L., Lister C. A new theory of enterorecirculation of amino acids and its use for depleting unwanted amino acids using oral enzyme-artificial cells as in removing phenylalanine in phenylketonuria. Artificial Cells, Blood Substitutes, and Immobilized Biotech. 1995; 23(1)1–21
  • Bourget L., Chang T. M.S. Phenylalanine ammonia-lyase immobilized in microcapsules for the depletion of phenylalanine in plasma in phenylketonuric rat model. Biochim et Biophysica Acta 1986; vol. 883: 432–438
  • Scriver C. The Hyperphenylalaninemias. “The Metabolic Basis of Inherited Disease”6th Edition, C. R. Scriver, A. L. Beaudet, W. S. Sly, D. Valle. McGraw-Hill Co., New York 1989; Volume 1: 495–546
  • Chang T. M.S. Semipermeable Microcapsules. Science 1964; 146: 524–525
  • Chang T. M.S. Artificial Cells in Immobilization Biotechnology. Biomat., Art. Cells & Immob. Biotech. 1992; vol. 20(5)1121–1143
  • Chang T. M.S. Artificial Cells. Encyclopedia of Human Biology. Academic Press. 1991; vol. 1: 377–383
  • Chang T. M.S. Medical Applications of Artificial Cells in Transfusion, Phenylketonuria, Essential Amino Acid Production, and Liver Support. Enzyme Engineering 1988; vol. 542: 507–514
  • Chang T. M.S., Poznansky M. J. Semipermeable Microcapsules Containing Catalase for Enzyme Replacement in Acatalasaemic Mice. Nature 1968; vol. 218: 243–245
  • Poznansky M. J., Chang T. M.S. Comparison of the Enzyme Kinetics and Immunological Properties of Catalase Immobilized by Microencapsulation and Catalase in Free Solution for Enzyme Replacement. Biochimica et Biophysica Acta 1974; vol. 334: 103–115
  • Chang T. M.S. The in vivo effects of semipermeable microcapsules containing L-asparaginase on 6C3HED lymphosarcoma. Nature 1971; 229(528)117–118
  • Chang T. M.S. Medical applications of immobilized proteins, enzymes and cells. Methods in Enzymology 1988; vol. 137: 444–457, Academic Press
  • Bourget L., Chang T. M.S. Phenylalanine ammonia-lyase immobilized in semipermeable microcapsules for enzyme replacement in phenylketonuria. Febs Letters 1985; vol. 180: 5–8
  • Bourget L., Chang T. M.S. Effects of oral administration of artificial cells immobilized phenylalanine ammonia-lyase on intestinal amino acids, of phenylketonuria rats. Biomat. Art. Cells. Art. Org. 1989; vol 17(2)161–181
  • Bourget L., Chang T. M.S. Artificial cells microencapsulated phenylalanine ammonia-lyase. Applied Biochem. and Biotech. 1984; vol. 10: 57–59
  • Chang T. M.S. Methods in the medical applications of immobilized proteins, enzymes and cells. Methods in Enzymology 1988; 137: 444–457
  • Shedlovsky A., McDonald J. D., Symula D., Dove W. F. Mouse models of human phenylketonuria. Genetics 1993; 134: 1205–1210
  • McDonald J. D., Bode V. C., Dove W. F., Shedlovsky A. Pah < hph-5 >: a mouse mutant deficient in phenylalanine hydroxylase. Proc. Natl. Acad. Sci. USA. 1990; 87: 1965–1967

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.