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Original Article

Enhanced Modulation of Hypotension in Endotoxemia by Concomitant Nitric Oxide Synthesis Inhibition and Nitric Oxide Scavenging

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Pages 153-162 | Published online: 11 Jul 2009

References

  • Parrilo J. E. Pathogenic mechanisms of septic shock. New Engl J Med 1993; 328: 1471–1477
  • Palmer RM. The discovery of nitric oxide in the vessel wall: a unifying concept in the pathogenesis of sepsis. Arch Surg 1993; 128: 396–401
  • Battafarano R J, Dunn DL. Role of nitric oxide during sepsis. Critical Care Medicine. 1992; 20: 1504–1505
  • Kilbourn R G, Griffith OW. Overproduction of nitric oxide in cytokine-mediated and septic shock. J Natl Cancer Inst 1992; 84: 827–831
  • Lorente J A, Landin L, Renes E, De Pablo R, Jorge P, Rodena E, Liste D. Role of nitric oxide in the hemodynamic changes of sepsis. Critical Care Medicine. 1993; 21: 759–767
  • Ochoa J B, Udekwu A O, Billiar T R, Curran R D, Cerra F B, Simmons R L, Peitzman AB. Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991; 214: 621–626
  • Evans T, Carpenter A, Kinderman H. Evidence of increased nitric oxide production in patients with the sepsis syndrome. Cir. Shock 1993; 41: 77–81
  • Nava E, Palmer R MJ, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial. Lancet 1991; 338: 1555–1557
  • Wright C E, Rees D D, Moncada S. Protective and pathological roles of nitric oxide in endotoxic shock. Cardiovascular Research 1992; 26: 48–57
  • Cobb P J, Natanson C, Hoffman W D, Lodato R F, Banks S, Koev C A, Solomon M A, Elin R J, Hosseini J M, Danner RL. Nw-amino-L-arginine, an inhibitor of nitric oxide synthesis, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin. J Exp Med 1992; 176: 1175–1182
  • Cobb P J, Cunnion R E, Danner RL. Nitric oxide as a target for therapy in septic shock. Crit Care Med 1993; 21: 1261–1263
  • Spain D A, Wilson M A, Bar-Natan M F, Garrison RN. Nitric oxide synthesis inhibition aggravates intestinal microvascular vasoconstriction and hypoperfusion of bacteremia. J Trauma 1994; 36: 720–725
  • Kim H W, Hughes J K, Breiding P, Greenburg AG. Nitric oxide scavenging: an alternative therapeutic approach to nitric oxide synthesis inhibition in nitric oxide mediated hypotension of sepsis. Surg. Forum 1994; 45: 67–69
  • Greenburg A G, Shooley M, Peskin GW. Improved retention of stroma-free hemoglobin solution by chemical modification. J Trauma 1977; 17: 501–504
  • Meyer J, Traber L D, Sharon N, Lentz C W, Makazawa H, Herndon D N, Noda H, Traber DL. Reversal of hyperdynamic responses to continuous endotoxin administration by inhibition of NO synthesis. J Appl Physiol 1992; 73: 324–328
  • Gibson Q H, Roughton F JW. The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin. J Physiol. 1957; 136: 507–526
  • Wang Q., Jacobs J., DeLeo J., Kruszyna H., Kruszyna R., Smith R., Wilcox D. Nitric oxide hemoglobin in mice and rats in endotoxic shock. Life Sciences 1991; 49: PL55–PL60
  • Kruszyna R, Kruszyna H, Smith R P, Thron C D, Wilcox DR. Nitrite conversion to nitric oxide in red cells and its stabilization as a nitrosylated valency hybrid of hemoglobin. J Pharmacol Exp Therap. 1987; 241: 307–313
  • Tiao G, Rafferty J, Ogle C, Fischer J E, Hasselgren P. Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6. Surgery 1994; 116: 332–338

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