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Artificial Cells, Blood Substitutes, and Biotechnology Volume 25, 1997 - Issue 3
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Original Article

Decreased Whole Blood Factor IX Activity Following Hemodilution with Hemoglobin A-Zero In-Vitro

Mimi S. Kim The Miriam Hospital, Brown University, Providence, RI, 02906, USA
,
Hae Won Kim The Miriam Hospital, Brown University, Providence, RI, 02906, USA
,
Joseph D. Sweeney The Miriam Hospital, Brown University, Providence, RI, 02906, USA
&
A. Gerson Greenburg The Miriam Hospital, Brown University, Providence, RI, 02906, USA
Pages 289-295 | Published online: 11 Jul 2009

References

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  • Bolin R. Hematologic effects of hemoglobin solutions in animals. Advances Blood Substitute Research. Alan R. Liss, Inc., New York 1983; 117–126
  • Savitsky JP. A clinical safety trial of stroma-free hemoglobin. Clin Pharmacol Ther. 1978; 23: 73–80
  • Kim HW, Awad M, Greenburg AG. Coagulation responses of human plasma after hemodilution with hemoglobin solution in-vitro. Artif Cells Blood Substit Immobil Biotechnol. 1994; 22(3)613–618
  • Kim MS. The Effects of Hemodilution on the Coagulation of Human Whole Blood. Undergraduate Thesis. Brown University. 1996
  • Seligson U. Activation of human factor VII in plasma and in purified systems. J Clin Invest. 1979; 64: 1056
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  • Ahmad SS, Rawala-Sheikh R., Walsh P. N. Comparative Interactions of Factor IX and Factor IXa with Human Platelets. J Biol Chem. 1989; 264: 3244–3251
  • Liebman, Howard A. The metal-dependent conformational changes in Factor IX associated with phospholipid binding. Eur J Biochem. 1993; 212: 339–345
  • Haemostasis and Thrombosis, L. Bloom, Arthur. Churchill Livingstone, New York 1994; 311
  • Burnier JP. Gamma-carboxyglutamic acid. Mol Cell Biol. 1981; 39: 191–207
  • Rawala-Sheikh R. Kinetics of Coagulation Factor X Activation by Platelet Bound Factor IX. Biochemistry. 1990; 29: 2606–2611
  • Sperling R. Metal Binding Properties of gamma-Carboxyglutamic Acid. Implications for the Vitamin K-dependent Blood Coagulation Proteins. J Biol Chem. 1978; 253: 3898–3906

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