Desensitization of 5HT₂ Receptors by Protein Kinase C Activation in Distal Pulmonary Vascular Smooth Muscle Cells in Culture

References

• Bhattacharya J, Nanjo S, Staub N C. Micropuncture measurement of lung microvascular pressure during 5-HT infusion. J Appl Physiol 1982; 52: 634–637
   Google Scholar
• Bouvier M, Leeb-Lundberg L MF, Benovic J L, Caron M G, Lefkowitz R J. Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy and phosphorylation of alphal and beta2 adrenergic receptors by protein kinase C and cAMP-dependent protein kinase. J Biol Chem 1987; 262: 3106–3113
   PubMedGoogle Scholar
• Davies P, Reid L, Jones R, Schloo B. Endothelium of the pulmonary vasculature in health and disease. Pulmonary Endothelium in Health and Disease, U Ryan. Marcel Dekker, New York 1987; 375–445
   Google Scholar
• Davies P, Smith B, Maddalo F, Fujiwara K, Reid L. The characteristics of rat lung pericytes in culture including their growth inhibition by subendothelial matrix. Microvasc Res 1987; 33: 300–314
   Google Scholar
• Davies P, Patton W. Peripheral and central vascular smooth muscle cells from rat lung exhibit different cytoskeletal protein profiles but similar growth factor requirements. J Cell Physiol 1994; 159: 399–406
   Google Scholar
• Dawson C A. Role of pulmonary vasomotion in physiology of the lung. Physiol Rev 1985; 64: 544–616
   Google Scholar
• Gitlin J D, D'Amore P A. Culture of retinal capillary cells using selective growth medium. Micro-vase Res 1979; 26: 74–80
   Google Scholar
• Go M, Yokoyama M, Akita H, Fuzuzaki H. Phorbol ester modulates serotonin-stimulated phosphoinositide breakdown in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 1988; 153: 51–58
   Google Scholar
• Herman I M, D'Amore P A. Microvascular pericytes contain muscle and non-muscle actions. J Cell Biol 1985; 101: 43–52
   PubMed Web of Science ®Google Scholar
• Julius D, Huang K N, Livelli T J, Axel R, Jessell T M. The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci (USA) 1990; 87: 928–932
   PubMed Web of Science ®Google Scholar
• Kagaya A, Mikuni M, Kusumi I, Yamamoto H, Takahashi K. Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C. J Pharmacol Exp Ther 1990; 255: 305–311
   PubMedGoogle Scholar
• Lee S L, Wang W W, Moore B J, Fanburg B L. Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture. Circ Res 1991; 68: 1362–1368
   PubMed Web of Science ®Google Scholar
• Leeb-Lundberg L MF, Cotecchia S, DeBlasi A, Caron M G, Lefkowitz R J. Regulation of adrenergic receptor function by phosphorylation. I. Agonist promoted desensitization and phosphorylation of a1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 and MF-2 smooth muscle cells. J Biol Chem 1987; 262: 3098–3105
   PubMedGoogle Scholar
• Lowry O H, Rosebrough N J, Farr A L, Randall R J. Protein measurement with folin phenol reagent. J Biol Chem 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Mene P, Simonson M S, Dunn M. Physiology of the mesangial cell. Physiol Rev 1989; 69: 1347–1424
   PubMed Web of Science ®Google Scholar
• Myers C L, Lazo J S, Pitt B R. Translocation of protein kinase C is associated with inhibition of 5-HT uptake by cultured endothelial cells. Am J Physiol (Lung Cell Mol Physiol 1) 1989; 257: L253–L258
   PubMedGoogle Scholar
• Nemecek G M, Coughlin S R, Handley D A, Moskowitz M A. Stimulation of aortic smooth muscle mitogenesis by serotonin. Proc Natl Acad Sci (USA) 1986; 83: 674–678
   PubMed Web of Science ®Google Scholar
• Pauwels P J, Compel P V, Leysen J E. Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells. Life Sci 1990; 47: 2009–2019
   Google Scholar
• Pitt B R, Weng W, Steve A R, Blakely R D, Reynolds I, Davies P. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. Am J Physiol (Lung Cell Mol Physiol 10) 1994; 266: L178–L186
   Google Scholar
• Raymond J. Protein kinase C induces phosphorylation and desensitization of the human 5-HT1A receptor. J Biol Chem 1991; 266: 14747–14753
   PubMed Web of Science ®Google Scholar
• Reid L M, Davies P. The control of cell proliferation iln pulmonary hypertension. Pulmonary Vascular Physiology and Pathophysiology, E K Weir, J Reeves. Marcel Dekker, New York 1990
   Google Scholar
• Sanders-Bush E, Breeding M, Knoth K, Tsutsumi M. Sertraline-induced desensitization of the serotonin 5HT-2 receptor transmembrane signaling system. Psychopharmacologia 1989; 99: 64–69
   PubMedGoogle Scholar
• Stroszjnader J, Wiklei H, Sun G Y. Effects of cerebral ischemia on [3H] inositol lipids and [3H] inositol phosphates of gerbil brain and subcellular fractions. J Neurochem 1987; 48: 943–948
   Google Scholar
• Takata S, Hirata Y, Takagi Y, Yoshimi H, Fukada Y, Fujita T. Phorbol ester modulates serotonin receptor-mediated increases in inositol phosphate production and calcium mobilization in cultured rat vascular smooth muscle cells. Fed Eur Biochem Soc Symp 1988; 234: 228–230
   Google Scholar
• Takuma N, Ganz M, Takuwa Y, Sterzel R B, Rasmussen H. Studies of the mitogenic effect of serotonin in rat renal mesangial cells. Am J Physiol (Renal Fluid Electrolyte Physiol 26) 1989; 257: F431–F439
   Google Scholar
• Weng W, Pitt B R. Activation of protein kinase C inhibits extraction of serotonin by perfused rat lung in situ. Am J Physiol (Lung Cell Mol Physiol 2) 1990; 258: L289–L293
   PubMed Web of Science ®Google Scholar
• Zar J H. Biostatistical Analysis (2nd ed.). Prentice-Hall, Englewood Cliffs, NJ. 1984
   Google Scholar