104
Views
24
CrossRef citations to date
0
Altmetric
Research Article

GOlf Complements A Gpa1 Null Mutation in Olf Saccharomyces Cerevisiae and Functionally Couples to the Ste2 Pheromone Receptor

, &
Pages 61-73 | Published online: 26 Sep 2008

References

  • King K., Dohlman H. G., Thorner J., Caron M. G., Lefkowitz R. J. Control of yeast mating signal transduction by a mammalian β2‐adrenergic receptor and Gs subunit. Science 1990; 250: 121–125
  • Price L. A., Kajkowski E. M., Hadcock J. R., Ozenberger B. A., Pausch M. H. Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway. Mol. Cell. Biol. 1995; 15: 6188–6195
  • Price L. A., Strnad J., Pausch M. H., Hadcock J. R. Pharmacological characterization of the rat A(2a) adenosine receptor functionally coupled to the yeast pheromone response pathway. Mol. Pharmacol. 1996; 50: 829–837
  • Kajkowski E. M., Price L. A., Pausch M. H., Young K. H., Ozenberger B. A. Investigation of growth hormone releasing hormone receptor structure and activity using yeast expression technologies. J. Recept. Signal. Transduct. Res. 1997; 17: 293–303
  • Burkholder A. C., Hartwell L. H. The yeast α‐factor receptor: structural properties deduced from the sequence of the STE2 gene. Nucleic Acids Res. 1985; 13: 8463–8475
  • Nakayama N., Miyajima A., Arai K. Nucleotide sequences of STE2 and STE3, cell type‐specific sterile genes from Saccharomyces cerevisiae. EMBO J. 1985; 4: 2643–2648
  • Hagen D. C., McCaffrey G., Sprague G. F. Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone α‐factor: gene sequence and implications for the structure of the presumed receptor. Proc. Natl. Acad. Sci. USA 1986; 83: 1418–1422
  • Whiteway M., Hougan L., Dignard D., Thomas D. Y., Bell L., Saari G. C., Grant F. J., O'Hara P., MacKay V. L. The STE4 and STE18 genes of yeast encode potential Gβ and γ subunits of the mating factor receptor‐coupled G protein. Cell 1989; 56: 467–477
  • Dietzel C., Kurjan J. The yeast SCG1 gene: a Gα‐like protein implicated in the a‐ and α‐factor response pathway. Cell 1987; 50: 1001–1010
  • Miyajima I., Nakafuku M., Nakajama N., Brenner C., Miyajima A., Kaibuchi K., Arai K., Kaziro Y., Matsumoto K. GPA1, a haploid‐specific essential gene, encodes a yeast homologue of mammalian G protein which may be involved in mating factor signal transduction. Cell 1987; 50: 1011–1019
  • Nomoto S., Nakayama N., Arai K., Matsumoto K. Regulation of the yeast pheromone response pathway by G protein subunits. EMBO J. 1990; 9: 691–696
  • Herskowitz I. MAP kinase pathways in yeast: for mating and more. Cell 1995; 80: 187–197
  • Dolan J. W., Fields S. Overproduction of the yeast STE12 protein leads to constitutive transcription induction. Genes Dev. 1990; 4: 492–502
  • Kurjan J. Pheromone response in yeast. Ann. Rev. Biochem. 1992; 61: 1097–1129
  • McCaffrey G., Clay F. J., Kelsay K., Sprague G. F. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 1987; 7: 2680–2690
  • Trueheart J., Boeke J. D., Fink G. R. Two genes required for cell fusion during yeast conjugation: evidence for a pheromone‐induced surface protein. Mol. Cell. Biol. 1987; 7: 2316–2328
  • Hagen D. C., McCaffrey G., Sprague J. F. Pheromone response elements are necessary and sufficient for basal and pheromone‐induced transcription of the FUS1 gene of Saccharomyces cerevisiae. Mol. Cell. Biol. 1991; 11: 2952–2961
  • Stryer L., Bourne H. R. G proteins: a family of signal transducers. Ann. Rev. Cell Biol. 1986; 2: 291–419
  • Chang F., Herskowitz I. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell 1990; 63: 999–1011
  • Kang Y‐S., Kane J., Kurjan J., Stadel J. M., Tipper D. J. Effects of expression of mammalian Gα and hybild mammalian‐yeast Gα proteins on the yeast pheromone response signal transduction pathway. Mol. Cell. Biol. 1990; 10: 2582–2590
  • Jones D. T., Reed R. R. Golf: an olfactory neuron‐specific G protein involved in odorant signal transduction. Science 1989; 244: 790–795
  • Hemsley A., Arnheim N., Toney M. D., Cortopassi G., Galas D. J. A simple method for site‐directed mutagenesis using the polymerase chain‐reaction. Nucleic Acids Res. 1989; 17: 6545–6551
  • Becker D. M., Guarente L. High‐efficiency transformation of yeast by electroporation. Methods Enzymol. 1991; 194: 186–187
  • Sikorski R. S., Hieter P. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 1989; 122: 19–27
  • Gritz L., Davies J. Plasmid‐encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae. Gene 1983; 25: 179–188

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.