Expression - Level Dependent Activation of Recombinant Human Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor: Effect of Human Parathyroid Hormone (1-34), (1-31), and (28-48)

References

• Schipani E., Karga H., Karaplis A., Potts J., Jr, Kronenberg H., Segre G., Abou-Samra A., Juppner H. Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 1993; 132: 2157
   PubMed Web of Science ®Google Scholar
• Potts J., Tregear G., Keutmann H., Niall H., Sauer R., Deftos L., Dawson B., Hogan M., Aurbach G. Synthesis of a biologically active N-terminal tetratriacontapeptide of parathyroid hormone. Proc. Natl. Acad. Sci. USA 1971; 68: 63
   PubMed Web of Science ®Google Scholar
• Donahue H., Fryer M., Eriksen E., Heath H. Differential effects of parathyroid hormone and its analogues on cytosolic calcium ion and cAMP levels in cultured rat osteoblast-like cells. J. Biol. Chem. 1988; 263: 13522
   PubMed Web of Science ®Google Scholar
• Hruska K., Moskowitz D., Esbrit P., Civitelli R., Westbrook S., Huskey M. Stimulation of inositol trisphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone. J. Clin. Invest. 1987; 79: 230
   PubMed Web of Science ®Google Scholar
• Patel S. Drugs in development for the treatment of metabolic bone disease. Exp. Opin. Invest. Drugs 1995; 5: 429
   Google Scholar
• Reeve J., PTH. a future role in the management of osteoporosis?. J. Bone Mine. rRes. 1996; 11: 440
   PubMed Web of Science ®Google Scholar
• Whitfield J., Morley P., Willick G., Ross V., Langille R., MacLean S., Barbier J., Isaacs R., Ohannessian-Barry L. Comparison of the abilities of human parathyroid hormone(l-31)NH2 and human parathyroid hormone-related protein(l-31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats. Calcif. Tissue Int. 1997; 61: 322
   PubMed Web of Science ®Google Scholar
• Whitfield J., Morley P., Willick G., Ross V., MacLean S., Barbier J., Isaacs R., Ohannessian-Barry L. Comparison of the ability of recombinant human parathyroid hormone, rhPTH-(l-84), and hPTH-(l-31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats. Calcif. Tissue Int. 1997; 60: 26
   PubMed Web of Science ®Google Scholar
• Whitfield J., Morley P., Willick G., Ross V., Barbier J., Isaacs R., Ohannessian-Barry L. Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(l-31)NH2 (Ostabolin). Calcif. Tissue Int. 1996; 58: 81
   PubMed Web of Science ®Google Scholar
• Jouishomme H., Whitfield J., Gagnon L., Maclean S., Isaacs R., Chak-ravarthy B., Durkin J., Neugebauer W., Willick G., Rixon R. Further definition of the protein kinase C activation domain of the parathyroid hormone. J. Bone Miner. Res. 1994; 9: 943
   PubMed Web of Science ®Google Scholar
• Rixon R., Whitfield J., Gagnon L., Isaacs R., Maclean S., Chakravarthy B., Durkin J., Neugebauer W., Ross V., Sung W., Willick G. Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase. J. Bone Miner. Res. 1994; 9: 1179
   PubMed Web of Science ®Google Scholar
• Jouishomme H., Whitfield J., Chakravarthy B., Durkin J., Gagnon L., Isaacs R., MacLean S., Neugebauer W., Willick G., Rixon R. The protein kinase-C activation domain of the parathyroid hormone. Endocrinology 1992; 130: 53
   PubMed Web of Science ®Google Scholar
• Schluter K., Hellstern H., Wingender E., Mayer H. The central part of parathyroid hormone stimulates thymidine incorporation of chondrocytes. J. Biol. Chem. 1989; 264: 11087
   PubMed Web of Science ®Google Scholar
• Sambrook J., Fritsch E., Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY 1989
   Google Scholar
• Yamamoto I., Shigeno C., Potts J. T., Jr., Segre G. V. Characterization and agonist-induced down-regulation of parathyroid hormone receptors in clonal rat osteosarcoma cells. Endocrinology 1988; 122: 1208
   PubMed Web of Science ®Google Scholar
• Grynkiewicz G., Poenie M., Tsien R. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985; 260: 3440
   PubMed Web of Science ®Google Scholar
• Pines M., Fukayama S., Costas K., Meurer E., Goldsmith P. K., Xu X., Muallem S., Behar V., Chorev M., Rosenblatt M., Tashjian A. H., Jr., Suva L. J. Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line. Bone 1996; 18: 381
   PubMed Web of Science ®Google Scholar
• McCauley L., Koh A., Beecher C., Cui Y., Decker J., Franceschi R. Effects of differentiation and transforming growth factor beta 1 on PTH/PTHrP receptor mRNA levels in MC3T3-E1 cells. J. Bone Miner. Res. 1995; 10: 1243
   PubMed Web of Science ®Google Scholar
• Lee K., Deeds J., Bond A., Juppner H., Abou-Samra A., Segre G. In situ localization of PTH/PTHrP receptor mRNA in the bone of fetal and young rats. Bone 1993; 14: 341
   PubMed Web of Science ®Google Scholar
• Lee K., Deeds J., Chiba S., Un-No M., Bond A., Segre G. Parathyroid hormone induces sequential c-for expression in bone cells in vivo: in situ localization of its receptor and c-fos messenger ribonucleic acids. Endocrinology 1994; 134: 441
   PubMed Web of Science ®Google Scholar
• Maeda S., Wu S., Juppner H., Green J., Aragay A. M., Fagin J. A., Clemens T. L. Cell-specific signal transduction of parathyroid hormone (PTH)-related protein through stably expressed recombinant PTH/PTHrP receptors in vascular smooth muscle cells [see comments]. Endocrinology 1996; 757: 3154
   Google Scholar
• Somjen D., Schluter K. D., Wingender E., Mayer H., Kaye A. M. Stimulation of cell proliferation in skeletal tissues of the rat by defined parathyroid hormone fragments. Biochem. J. 1991; 277: 863
   PubMed Web of Science ®Google Scholar
• Somjen D., Binderman L., Schluter K. D., Wingender E., Mayer H., Kaye A. M. Stimulation by defined parathyroid hormone fragments of cell proliferation in skeletal-derived cell cultures. Biochem. J. 1990; 272: 781
   PubMed Web of Science ®Google Scholar
• Takasu H., Bringhurst F. Type-1 parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(l-34). Endocrinology 1998; 139: 4293
   PubMed Web of Science ®Google Scholar