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Mini-Review

On the roles of Mg in the activation of G proteins

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Pages 372-375 | Received 02 Jul 2010, Accepted 10 Jul 2010, Published online: 23 Aug 2010

References

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  • Iyengar R, Birnbaumer L. Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides. Proc Natl Acad Sci USA 1982, 79, 5179–5183.
  • Raw AS, Coleman DE, Gilman AG, Sprang SR. Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 –> Val mutant of Gialpha1. Biochemistry 1997, 36, 15660–15669.
  • Zurita A, Zhang Y, Pedersen L, Darden T, Birnbaumer L. Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPases. Proc Natl Acad Sci USA 2010, 107, 9596–9601.

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