The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells

References

• Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004, 351, 1425–1436.
   PubMed Web of Science ®Google Scholar
• Mandegar M, Fung YC, Huang W, Remillard CV, Rubin LJ, Yuan JX. Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension. Microvasc Res 2004, 68, 75–103.
   PubMed Web of Science ®Google Scholar
• Pidgeon GP, Tamosiuniene R, Chen G, Leonard I, Belton O, Bradford A, Fitzgerald DJ. Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2. Circulation 2004, 110, 2701–2707.
   PubMed Web of Science ®Google Scholar
• Rabinovitch M. Elastase and the pathobiology of unexplained pulmonary hypertension. Chest 1998, 114, 213S–224S.
   Google Scholar
• Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2003, 285, L740–L754.
   PubMed Web of Science ®Google Scholar
• Cobb MH, Goldsmith EJ. How MAP kinases are regulated. J Biol Chem 1995, 270, 14843–14846.
   PubMed Web of Science ®Google Scholar
• Nishida S, Matsuoka H, Tsubaki M, Tanimori Y, Yanae M, Fujii Y, Iwaki M. Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK. Mol Cell Biochem 2005, 269, 109–114.
   PubMed Web of Science ®Google Scholar
• Wang W, Prince CZ, Mou Y, Pollman MJ. Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. JBC 2002, 277, 21723–21729.
   PubMed Web of Science ®Google Scholar
• McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007, 1773, 1263–1284.
   PubMed Web of Science ®Google Scholar
• Jimmy YCC, Quach KT, Cabrera BL, Cabral JA, Beck SE, Carethers JM. RAS/ERK modulates TGFβ-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis 2007, 28, 2321–2327.
   Google Scholar
• Beck SE, Carethers JM. BMP suppresses PTEN expression via RAS/ERK signaling. Cancer Biol Ther 2007, 6, 1313–1317.
   Google Scholar
• Gardai SJ, Whitlock BB, Xiao YQ, Bratton DB, Henson PM. Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP. J Biol Chem 2004, 279, 44695–44703.
   PubMedGoogle Scholar
• Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER. Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. Circ Res 2003, 92, 992–1000.
   PubMed Web of Science ®Google Scholar
• Wang S, Wang Y, Jiang J, Wang R, Li L, Qiu Z, Wu H, Zhu D. 15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway. Prostaglandins Other Lipid Mediat 2010, 91, 51–60.
   PubMed Web of Science ®Google Scholar
• Lu C, Liu Y, Tang X, Ye H, Zhu D. Role of 15-hydroxyeicosatetraenoic acid in phosphorylation of ERK1/2 and caldesmon in pulmonary arterial smooth muscle cells. Can J Physiol Pharmacol 2006, 84, 1061–1069.
   Google Scholar
• Guo L, Tang X, Tian H, Liu Y, Wang Z, Wu H, Wang J, Guo S, Zhu D. Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells. Eur J Pharmacol 2008, 587, 187–195.
   PubMed Web of Science ®Google Scholar
• Wang Z, Tang X, Li Y, Leu C, Guo L, Zheng X, Zhu D. 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. Eur J Pharmacol 2008, 588, 9–17.
   PubMed Web of Science ®Google Scholar
• Li JM, Brooks G. Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system; potential targets for therapy? Eur Heart J 1999, 20, 406–420.
   PubMed Web of Science ®Google Scholar
• Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH, Wang J. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem 2007, 282, 33888–33895.
   PubMed Web of Science ®Google Scholar
• Vasudevan KM, Gurumurthy S, Rangnekar VM. Suppression of PTEN expression by NF-kappa B prevents apoptosis. Mol Cell Biol 2004, 24, 1007–1021.
   PubMed Web of Science ®Google Scholar
• Han W, Tang X, Wu H, Liu Y, Zhu D. Role of ERK1/2 signaling pathways in 4-aminopyridine-induced rat pulmonary vasoconstriction. Eur J Pharmacol 2007, 569, 138–144.
   PubMedGoogle Scholar
• Chu X, Tang X, Guo L, Bao H, Zhang S, Zhang J, Zhu D. Hypoxia suppresses KV1.5 channel expression through endogenous 15-HETE in rat pulmonary artery. Prostaglandins Other Lipid Mediat 2009, 88, 42–50.
   Google Scholar
• McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 2004, 95, 830–840.
   PubMed Web of Science ®Google Scholar
• Ekhterae D, Platoshyn O, Krick S, Yu Y, McDaniel SS, Yuan JX. Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells. Am J Physiol, Cell Physiol 2001, 281, C157–C165.
   PubMedGoogle Scholar
• Wang X, Gjörloff-Wingren A, Saxena M, Pathan N, Reed JC, Mustelin T. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase. J Immunol 2000, 164, 1934–1939.
   PubMed Web of Science ®Google Scholar
• Weng LP, Brown JL, Baker KM, Ostrowski MC, Eng C. PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway. Hum Mol Genet 2002, 11, 1687–1696.
   PubMed Web of Science ®Google Scholar
• Gu J, Tamura M, Yamada KM. Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol 1998, 143, 1375–1383.
   PubMed Web of Science ®Google Scholar
• Deveraux QL, Reed JC. IAP family proteins—suppressors of apoptosis. Genes Dev 1999, 13, 239–252.
   PubMed Web of Science ®Google Scholar
• Wang G, Ahmad KA, Harris NH, Ahmed K. Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells. Mol Cell Biochem 2008, 316, 91–97.
   Google Scholar