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Research Article

Topiramate modulates hippocampus NMDA receptors via brain Ca2+ homeostasis in pentylentetrazol-induced epilepsy of rats

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Pages 173-179 | Received 09 Jan 2011, Accepted 16 Jan 2011, Published online: 09 Mar 2011

References

  • Reid CA, Berkovic SF, Petrou S. Mechanisms of human inherited epilepsies. Prog Neurobiol 2009, 87, 41–57.
  • Shin HS, Cheong EJ, Choi S, Lee J, Na HS. T-type Ca2+ channels as therapeutic targets in the nervous system. Curr Opin Pharmacol 2008, 8, 33–41.
  • Auzmendi J, González N, Girardi E. The NMDAR subunit NR2B expression is modified in hippocampus after repetitive seizures. Neurochem Res 2009, 34, 819–826.
  • Nazıroğlu M. Role of selenium on calcium signaling and oxidative stress- induced molecular pathways in epilepsy. Neurochem Res 2009, 34, 2181–2191.
  • Bejarano I, Redondo PC, Espino J, Rosado JA, Paredes SD, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB. Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells. J Pineal Res 2009, 46, 392–400.
  • Naziroglu M. New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem Res 2007, 32, 1990–2001.
  • Arundhati K, Mohan D S, Padma T. Reduced Activity of Red Cell Na+ K+ ATPase and Ca2+ ATPase in Patients with Idiopathic Generalized Epilepsy. Int J Hum Genet 2003, 3, 59–63.
  • Kutluhan S, Naziroglu M, Celik O, Yilmaz M. Effects of selenium and topiramate on lipid peroxidation and antioxidant vitamin levels in blood of pentylentetrazol-induced epileptic rats. Biol Trace Elem Res 2009, 129, 181–189.
  • Wang CX, Shuaib A. NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. Curr Drug Targets CNS Neurol Disord 2005, 4, 143–151.
  • De Deyn PP, Macdonald RL. Effects of antiepileptic drugs on reduction of GABA responses by PTZ and DMCM on mouse neurons in cell culture. Prog Neurobiol 1995, 47, 477–511.
  • Világi I, Dobó E, Borbély S, Czégé D, Molnár E, Mihály A. Repeated 4-aminopyridine induced seizures diminish the efficacy of glutamatergic transmission in the neocortex. Exp Neurol 2009, 219, 136–145.
  • Raffa RB, Finno KE, Tallarida CS, Rawls SM. Topiramate-antagonism of L-glutamate-induced paroxysms in planarians. Eur J Pharmacol 2010, 649, 150–153.
  • White HS, Smith MD, Wilcox KS. Mechanisms of action of antiepileptic drugs. Int Rev Neurobiol 2007, 81, 85–110.
  • Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology 2005, 49, 456–464.
  • Naziroglu M, Kutluhan S, Yilmaz M. Selenium and topiramate modulates brain microsomal oxidative stress values, Ca2+-ATPase activity, and EEG records in pentylentetrazol-induced seizures in rats. J Membr Biol 2008, 225, 39–49.
  • Eren I, Naziroglu M, Demirdas A. Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain. Neurochem Res 2007, 32, 1188–1195.
  • Naziroglu M, Kutluhan S, Uguz AC, Celik O, Bal R, Butterworth PJ. Topiramate and vitamin e modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats. J Membr Biol 2009, 229, 131–140.
  • Niggli V, Adunyah ES, Penniston JT, Carafoli E. Purified (Ca2+Mg2+)-ATPase of the erythrocyte membrane. Reconstitution and effect of calmodulin and phospholipids. J Biol Chem 1981, 256, 395–401.
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193, 265–275.
  • Dilek M, Naziroglu M, Baha Oral H, Suat Ovey I, Küçükayaz M, Mungan MT, Kara HY, Sütçü R. Melatonin modulates hippocampus NMDA receptors, blood and brain oxidative stress levels in ovariectomized rats. J Membr Biol 2010, 233, 135–142.
  • Croucher MJ, Collins JF, Meldrum BS. Anticonvulsant action of excitatory amino acid antagonists. Science 1982, 216, 899–901.
  • Pal S, Limbrick DD Jr, Rafiq A, DeLorenzo RJ. Induction of spontaneous recurrent epileptiform discharges causes long-term changes in intracellular calcium homeostatic mechanisms. Cell Calcium 2000, 28, 181–193.
  • Parsons JT, Churn SB, Kochan LD, DeLorenzo RJ. Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake. J Neurochem 2000, 75, 1209–1218.
  • Sun DA, Sombati S, Blair RE, DeLorenzo RJ. Calcium-dependent epileptogenesis in an in vitro model of stroke-induced “epilepsy”. Epilepsia 2002, 43, 1296–1305.
  • Rosenblatt DE, Lauter CJ, Trams EG. Deficiency of a Ca2+ATPase in brains of seizure prone mice. J Neurochem 1976, 27, 1299–1304.
  • Qian J, Noebels JL. Topiramate alters excitatory synaptic transmission in mouse hippocampus. Epilepsy Res 2003, 55, 225–233.
  • Mathern GW, Pretorius JK, Mendoza D, Leite JP, Chimelli L, Born DE, Fried I, Assirati JA, Ojemann GA, Adelson PD, Cahan LD, Kornblum HI. Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients. Ann Neurol 1999, 46, 343–358.
  • Kitano T, Matsumura S, Seki T, Hikida T, Sakimura K, Nagano T, Mishina M, Nakanishi S, Ito S. Characterization of N-methyl-D-aspartate receptor subunits involved in acute ammonia toxicity. Neurochem Int 2004, 44, 83–90.

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