References
- Kneko M, Saito H, Matsumoto T, Matsuda Y, Vaught JL, Dionne CA, Angeles TS, Glicksman MA, Neff NT, Rotella DP, Kauer JC, Mallamo JP, Hudkins RL, Murakate C. Neurotrophic 3,9-bis[(alkylthin) methyl]-and-bis(alkoxymethyl)-K-252a derivatives. J Med Chem 1997, 40, 1863–1869.
- Bozyczko-Coyne D, Saporito MS, Hudkins RL. Targeting the JNK pathway for therapeutic benefit in CNS disease. Curr Drug Targets CNS Neurol Disord 2002, 1, 31–49.
- Pan J, Zhang QG, Zhang GY. The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. Neuroscience 2005, 131, 147–159.
- Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103, 239–252.
- Faris M, Latinis KM, Kempiak SJ, Koretzky GA, Nel A. Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol Cell Biol 1998, 18, 5414–5424.
- Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, Gotoh Y. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 2004, 23, 1889–1899.
- Chang LK, Putcha GV, Deshmukh M, Johnson EM Jr. Mitochondrial involvement in the point of no return in neuronal apoptosis. Biochimie 2002, 84, 223–231.
- Guan QH, Pei DS, Zong YY, Xu TL, Zhang GY. Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways. Neuroscience 2006, 139, 609–627.
- Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson EM Jr. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 2003, 38, 899–914.
- Pei DS, Wang XT, Liu Y, Sun YF, Guan QH, Wang W, Yan JZ, Zong YY, Xu TL, Zhang GY. Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence. Brain 2006, 129, 465–479.
- Gu Z, Jiang Q, Zhang G. c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury. Neuroreport 2001, 12, 897–900.
- Tian H, Zhang Q, Li H, Zhang G. Antioxidant N-acetylcysteine and AMPA/KA receptor antagonist DNQX inhibited mixed lineage kinase-3 activation following cerebral ischemia in rat hippocampus. Neurosci Res 2003, 47, 47–53.
- Lawrence MS, Ho DY, Sun GH, Steinberg GK, Sapolsky RM. Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J Neurosci 1996, 16, 486–496.
- Zhao H, Yenari MA, Cheng D, Sapolsky RM, Steinberg GK. Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity. J Neurochem 2003, 85, 1026–1036.
- Yin XM, Luo Y, Cao G, Bai L, Pei W, Kuharsky DK, Chen J. Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia. J Biol Chem 2002, 277, 42074–42081.
- Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 2002, 22, 4929–4942.
- Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci USA 1997, 94, 3668–3672.
- Brichese L, Cazettes G, Valette A. JNK is associated with Bcl-2 and PP1 in mitochondria: paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2. Cell Cycle 2004, 3, 1312–1319.
- Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y. 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. J Biol Chem 2003, 278, 2058–2065.
- Sawada M, Sun W, Hayes P, Leskov K, Boothman DA, Matsuyama S. Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat Cell Biol 2003, 5, 320–329.
- Lowry OH, Rosebrough HJ and Farr AL. Protein measurement with Folin-Phenol reagent. J Biol Chem 1951, 193, 265–275.
- Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat, Rev., Cancer 2002, 2, 647–656.