Silencing of the integrin-linked kinase gene induces the apoptosis in ovarian carcinoma

References

• Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin 2009, 59, 225–249.
   PubMed Web of Science ®Google Scholar
• Glud E, Kjaer SK, Thomsen BL, Høgdall C, Christensen L, Høgdall E, Bock JE, Blaakaer J. Hormone therapy and the impact of estrogen intake on the risk of ovarian cancer. Arch Intern Med 2004, 164, 2253–2259.
   PubMed Web of Science ®Google Scholar
• Winter RN, Kramer A, Borkowski A, Kyprianou N. Loss of caspase-1 and caspase-3 protein expression in human prostate cancer. Cancer Res 2001, 61, 1227–1232.
   PubMed Web of Science ®Google Scholar
• Feng Q, Li P, Salamanca C, Huntsman D, Leung PCK, Auersperg N. Caspase-1α is down-regulated in human ovarian cancer cells and the overexpression of caspase-1α induces apoptosis. Cancer Res 2005, 65, 8591–8596.
   Google Scholar
• Jiang D, Brady CA, Johnson TM, Lee EY, Park EJ, Scott MP, Attardi LD. Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. PNAS 2011, 108, 17123–17128.
   PubMed Web of Science ®Google Scholar
• Huang Q, Lan F, Zheng Z, Xie F, Han J, Dong L, Xie Y, Zheng F. Akt2 suppresses GAPDH mediated-apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation. J Biol Chem 2011, 286, 42211–42220.
   PubMed Web of Science ®Google Scholar
• Vivas-Mejia PE, Rodriguez-Aguayo C, Han H-D, Shahzad MMK, Valiyeva F, Shibayama M, Chavez-Reyes A, Sood AK, Lopez-Berestein G. Silencing survivin splice variant 2B leads to antitumor activity in taxane-resistant ovarian cancer. Clin Cancer Res 2011, 17, 3716–3726.
   Google Scholar
• Ahmed N, Oliva K, Rice GE, Quinn MA. Regular articles – molecular oncology, markers, clinical correlates: Cell-Free 59 kDa immunoreactive integrin-linked kinase: A novel marker for ovarian carcinoma. Clin Cancer Res 2004, 10, 2415–2420.
   PubMed Web of Science ®Google Scholar
• Hannigan GE, Dedhar S. Protein kinase mediators of integrin signal transduction. J Mol Med 1997, 75, 35–44.
   PubMedGoogle Scholar
• Radeva G, Petrocelli T, Behrend E, Leung-Hagesteijn C, Filmus J, Slingerland J, Dedhar S. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J Biol Chem 1997, 272, 13937–13944.
   PubMed Web of Science ®Google Scholar
• Rosanò L, Spinella F, Di Castro V, Nicotra MR, Dedhar S, de Herreros AG, Natali PG, Bagnato A. Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res 2005, 65, 11649–11657.
   PubMed Web of Science ®Google Scholar
• Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA 2000, 97, 3207–3212.
   PubMed Web of Science ®Google Scholar
• Kaneko Y, Kitazato K, Basaki Y. Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor. J Cell Sci 2004, 117, 407–415.
   PubMed Web of Science ®Google Scholar
• Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D. Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer. Carcinogenesis 2007, 28, 1067–1073.
   PubMed Web of Science ®Google Scholar
• Chatzaki E, Makrigiannakis A, Margioris AN, Kouimtzoglou E, Gravanis A. The Fas/FasL apoptotic pathway is involved in kappa-opioid-induced apoptosis of human endometrial stromal cells. Mol Hum Reprod 2001, 7, 867–874.
   Google Scholar
• Imanishi Y, Hu B, Xiao G, Yao X, Cheng, S-Y. Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-Akt-B cell lymphoma 2 (bcl-2) pathway. J Biol Chem 2011, 286, 29249–29260.
   PubMed Web of Science ®Google Scholar
• Watzka SB, Rauscher-Pötsch I, Stubenberger E, Getman V, Setinek U, Tötsch M, Pötschger U, Müller, MR. Immunoreactivity of integrin-linked kinase in primary non-small-cell lung cancer and survival after curative resection. Eur J Cardiothorac Surg 2010, 38, 254–259.
   Google Scholar
• Carracedo J, Ramírez R, Soriano S, Martín-Malo A, Rodríguez M, Aljama P. Caspase-3-dependent pathway mediates apoptosis of human mononuclear cells induced by cellulosic haemodialysis membranes. Nephrol Dial Transplant 2002, 17, 1971–1977.
   Google Scholar
• Bressenot A, Marchal S, Bezdetnaya L, Garrier J, Guillemin F, Plénat F. Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma. J Histochem Cytochem 2009, 57, 289–300.
   PubMed Web of Science ®Google Scholar
• Aiuchi T, Mihara S, Nakaya M, Masuda Y, Nakajo S, Nakaya K. Zinc ions prevent processing of caspase-3 during apoptosis induced by geranylgeraniol in HL-60 cells. J Biochem 1998, 124, 300–303.
   PubMed Web of Science ®Google Scholar
• Kossmehl P, Shakibaei M, Cogoli A, Infanger M, Curcio F, Schönberger J, Eilles C, Bauer J, Pickenhahn H, Schulze-Tanzil G, Paul M, Grimm D. Weightlessness induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways. Endocrinology 2003, 144, 4172–4179.
   PubMed Web of Science ®Google Scholar
• Zhang L, Ma J, Li Y, Guo L, Ran Y, Liu S, Jiang C, Zhu D. 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90. Life Sci 2010, 87, 223–231.
   Google Scholar
• Ma J, Zhang L, Li S, Liu S, Ma C, Li W, Falck JR, Manthati VL, Reddy DS, Medhora M, Jacobs ER, Zhu D. 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. Exp Cell Res 2010, 316, 2340–2353.
   PubMed Web of Science ®Google Scholar
• Basu A, Castle VP, Bouziane M, Bhalla K, Haldar S. Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: Synergistic action of estrogen metabolite and ligands of death receptor family. Cancer Res 2006, 66, 4309–4318.
   Google Scholar