Aspects on the integrative actions of the brain from neural networks to “brain-body medicine”

References

• Burke RE. Sir Charles Sherrington’s the integrative action of the nervous system: A centenary appreciation. Brain 2007, 130, 887–894.
   PubMed Web of Science ®Google Scholar
• Gibson WC. (2002). Sir Charles Sherrington, O.M., P.R.S. (1857–1952).. In: Rose FC. ed. Twentieth century neurology. The British contribution. London: Imperial College Press, 1–7.
   Google Scholar
• Levine DN. Sherrington’s “The Integrative action of the nervous system”: A centennial appraisal. J Neurol Sci 2007, 253, 1–6.
   PubMed Web of Science ®Google Scholar
• Breathnach CS. Charles Scott Sherrington’s Integrative action: A centenary notice. J R Soc Med 2004, 97, 34–36.
   PubMed Web of Science ®Google Scholar
• Butt AM. ATP: A ubiquitous gliotransmitter integrating neuron-glial networks. Semin Cell Dev Biol 2011, 22, 205–213.
   PubMed Web of Science ®Google Scholar
• Figley CR, Stroman PW. The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals. Eur J Neurosci 2011, 33, 577–588.
   PubMed Web of Science ®Google Scholar
• Kettenmann H, Hanisch UK, Noda M, Verkhratsky A. Physiology of microglia. Physiol Rev 2011, 91, 461–553.
   PubMed Web of Science ®Google Scholar
• Yi CX, Habegger KM, Chowen JA, Stern J, Tschöp MH. A role for astrocytes in the central control of metabolism. Neuroendocrinology 2011, 93, 143–149.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Fuxe K. Volume transmission as a key feature of information handling in the central nervous system possible new interpretative value of the Turing’s B-type machine. Prog Brain Res 2000, 125, 3–19.
   PubMed Web of Science ®Google Scholar
• Vizi ES, Kiss JP, Lendvai B. Nonsynaptic communication in the central nervous system. Neurochem Int 2004, 45, 443–451.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Guidolin D, Guescini M, Genedani S, Fuxe K. Understanding wiring and volume transmission. Brain Res Rev 2010, 64, 137–159.
   PubMedGoogle Scholar
• Jacob F. (1970). La logique du vivant. Une histoire de l’hérédité. Paris: Gallimard Editions.
   Google Scholar
• Agnati LF, Fuxe K. New concepts on the structure of the neuronal networks: The miniaturization and hierarchical organization of the central nervous system. (Hypothesis). Biosci Rep 1984, 4, 93–98.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Guidolin D, Fuxe K. The brain as a system of nested but partially overlapping networks. Heuristic relevance of the model for brain physiology and pathology. J Neural Transm 2007, 114, 3–19.
   PubMed Web of Science ®Google Scholar
• Hebb DO. (1949). The organization of behavior. New York: John Wiley & Sons [Española, ed. Organización de la conducta. Madrid: Debate, (1985)].
   Google Scholar
• Wang XJ. Synaptic reverberation underlying mnemonic persistent activity. Trends Neurosci 2001, 24, 455–463.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Guidolin D, Carone C, Dam M, Genedani S, Fuxe K. Understanding neuronal molecular networks builds on neuronal cellular network architecture. Brain Res Rev 2008, 58, 379–399.
   PubMed Web of Science ®Google Scholar
• Anderson ML. Evolution of cognitive function via redeployment of brain areas. Neuroscientist 2007, 13, 13–21.
   PubMed Web of Science ®Google Scholar
• Anderson ML. Neural reuse: A fundamental organizational principle of the brain. Behav Brain Sci 2010, 33, 245–66; discussion 266.
   PubMed Web of Science ®Google Scholar
• Jacob F. Evolution and tinkering. Science 1977, 196, 1161–1166.
   PubMed Web of Science ®Google Scholar
• Eccles JC. (1964). The physiology of synapses. Berlin: Springer.
   Google Scholar
• Fuxe K. Cellular localization of monoamines in the median eminence and the infundibular stem of some mammals. Z Zellforsch Mikrosk Anat 1964, 61, 710–724.
   PubMedGoogle Scholar
• Agnati LF, Fuxe K, Calza L, Goldstein M, Toffano G, Giardino L, Zoli M. Further studies on the effects of the GM1 ganglioside on the degenerative and regenerative features of mesostriatal dopamine neurons. Acta Physiol Scand Suppl 1984, 532, 37–44.
   PubMedGoogle Scholar
• Kuhar MJ, Unnerstall JR, De Souza EB. Receptor mapping in neuropharmacology by autoradiography: Some technical problems. NIDA Res Monogr 1985, 62, 1–12.
   PubMedGoogle Scholar
• Einarsson P, Hallman H, Jonsson G. Quantitative microfluorimetry of formaldehyde induced fluorescence of dopamine in the caudate nucleus. Med Biol 1975, 53, 15–24.
   PubMedGoogle Scholar
• Sternberger LA. (1979). Immunocytochemistry. New York: John Wiley.
   Google Scholar
• Agnati LF, Andersson K, Wiesel F, Fuxe K. A method to determine dopamine levels and turnover rate in discrete dopamine nerve terminal systems by quantitative use of dopamine fluorescence obtained by Falck–Hillarp methodology. J Neurosci Methods 1979, 1, 365–373.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Fuxe K, Benfenati F, Zini I, Zoli M, Fabri L, Harfstrand AI. Computer-assisted morphometry and microdensitometry of transmitter-identified neurons with special reference to the mesostriatal dopamine pathway: Methodological aspects. Acta Physiol Scand Suppl 1984, 532, 6–36.
   Google Scholar
• Andersson K, Fuxe K, Agnati LF. Determinations of catecholamine half-lives and turnover rates in discrete catecholamine nerve terminal systems of the hypothalamus, the preoptic region and the forebrain by quantitative histofluorimetry. Acta Physiol Scand 1985, 123, 411–426.
   PubMedGoogle Scholar
• Jansson A, Goldstein M, Tinner B, Zoli M, Meador-Woodruff JH, Lew JY, Levey AI, Watson S, Agnati LF, Fuxe K. On the distribution patterns of D1, D2, tyrosine hydroxylase and dopamine transporter immunoreactivities in the ventral striatum of the rat. Neuroscience 1999, 89, 473–489.
   PubMed Web of Science ®Google Scholar
• Descarries L, Seguela P, Watkins KC. (1991). Nonjunctional relationship of monoamine axon terminals in the cerebral cortex of adult rat.. In: Fuxe K, Agnati LF. eds. Volume transmission in the brain: Novel mechanisms for neural transmission. New York: Raven Press, 53–62.
   Google Scholar
• Agnati LF, Fuxe K, Zoli M, Ozini I, Toffano G, Ferraguti F. A correlation analysis of the regional distribution of central enkephalin and β-endorphin immunoreactive terminals and of opiate receptors in adult and old male rats. Evidence for the existence of two main types of communication in the central nervous system: The volume transmission and the wiring transmission. Acta Physiol Scand 1986, 128, 201–207.
   PubMedGoogle Scholar
• Vizi ES. Non-synaptic interactions between neurons: Modulation of neurochemical transmission. New York: John Wiley, 1984.
   Google Scholar
• Nicholson C. Factors governing diffusing molecular signals in brain extracellular space. J Neural Transm 2005, 112, 29–44.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Fuxe K, Nicholson C, Sykova E. eds. (2000). Progress in brain research: Volume transmission revisited. Amsterdam: Elsevier Science, 125.
   Google Scholar
• Fuxe K, Dahlström AB, Jonsson G, Marcellino D, Guescini M, Dam M, Manger P, Agnati L. The discovery of central monoamine neurons gave volume transmission to the wired brain. Prog Neurobiol 2010, 90, 82–100.
   PubMed Web of Science ®Google Scholar
• Rodbell M. The complex regulation of receptor-coupled G-proteins. Adv Enzyme Regul 1997, 37, 427–435.
   PubMedGoogle Scholar
• Gilman AG. Nobel Lecture. G proteins and regulation of adenylyl cyclase. Biosci Rep 1995, 15, 65–97.
   PubMed Web of Science ®Google Scholar
• Lefkowitz RJ. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J Biol Chem 1998, 273, 18677–18680.
   PubMed Web of Science ®Google Scholar
• Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov 2006, 5, 993–996.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Fuxe K, Zini I, Lenzi P, Hökfelt T. Aspects on receptor regulation and isoreceptor identification. Med Biol 1980, 58, 182–187.
   PubMedGoogle Scholar
• Fuxe K, Agnati LF, Benfenati F, Celani M, Zini I, Zoli M, Mutt V. Evidence for the existence of receptor–receptor interactions in the central nervous system. Studies on the regulation of monoamine receptors by neuropeptides. J Neural Transm Suppl 1983, 18, 165–179.
   PubMedGoogle Scholar
• Fuxe K, Canals M, Torvinen M, Marcellino D, Terasmaa A, Genedani S, Leo G, Guidolin D, Diaz-Cabiale Z, Rivera A, Lundstrom L, Langel U, Narvaez J, Tanganelli S, Lluis C, Ferré S, Woods A, Franco R, Agnati LF. Intramembrane receptor-receptor interactions: A novel principle in molecular medicine. J Neural Transm 2007, 114, 49–75.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Guidolin D, Leo G, Carone C, Genedani S, Fuxe K. Receptor-receptor interactions: A novel concept in brain integration. Prog Neurobiol 2010, 90, 157–175.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Fuxe K, Zoli M, Rondanini C, Ogren SO. New vistas on synaptic plasticity: The receptor mosaic hypothesis of the engram. Med Biol 1982, 60, 183–190.
   PubMedGoogle Scholar
• Agnati LF, Barlow PW, Baluška F, Tonin P, Guescini M, Leo G, Fuxe K. A new theoretical approach to the functional meaning of sleep and dreaming in humans based on the maintenance of ‘predictive psychic homeostasis’. Commun Integr Biol 2011, 4, 640–654.
   PubMedGoogle Scholar
• Agnati LF, Guidolin D, Leo G, Fuxe K. A boolean network modelling of receptor mosaics relevance of topology and cooperativity. J Neural Transm 2007, 114, 77–92.
   PubMed Web of Science ®Google Scholar
• Kenakin T, Agnati LF, Caron M, Fredholm B, Guidoli D, Kobilka B, Lefkowitz RW, Lohse M, Woods A, Fuxe K. International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: Finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? J Recept Signal Transduct Res 2010, 30, 284–286.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Fuxe K. Subcortical limbic 3H-N-propylnorapomorphine binding sites are markedly modulated by cholecystokinin-8 in vitro. Biosci Rep 1983, 3, 1101–1105.
   PubMed Web of Science ®Google Scholar
• Carlsson A, Lindqvist M. Effect of chlorpromazine or haloperidol on formation of 3methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol (Copenh) 1963, 20, 140–144.
   PubMedGoogle Scholar
• Agnati LF, Franzen O, Ferré S, Leo G, Franco R, Fuxe K. Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: Focus on motor learning in the basal ganglia. J Neural Transm Suppl 2003, 65, 1–28.
   PubMedGoogle Scholar
• Guidolin D, Fuxe K, Neri G, Nussdorfer GG, Agnati LF. On the role of receptor-receptor interactions and volume transmission in learning and memory. Brain Res Rev 2007, 55, 119–133.
   PubMedGoogle Scholar
• Schwarzschild MA, Agnati L, Fuxe K, Chen JF, Morelli M. Targeting adenosine A2A receptors in Parkinson’s disease. Trends Neurosci 2006, 29, 647–654.
   PubMed Web of Science ®Google Scholar
• Fuxe K, Marcellino D, Woods AS, Giuseppina L, Antonelli T, Ferraro L, Tanganelli S, Agnati LF. Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: Relevance for schizophrenia. J Neural Transm 2009, 116, 923–939.
   PubMed Web of Science ®Google Scholar
• Baj-Krzyworzeka M, Szatanek R, Weglarczyk K, Baran J, Urbanowicz B, Branski P, Ratajczak MZ, Zembala M. Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes. Cancer Immunol Immunother 2006, 55, 808–818.
   PubMed Web of Science ®Google Scholar
• Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, Conover DO, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS 2003, 17, 33–42.
   PubMed Web of Science ®Google Scholar
• MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A. Rapid secretion of interleukin-1β by microvesicle shedding. Immunity 2001, 15, 825–835.
   PubMed Web of Science ®Google Scholar
• Rialland P, Lankar D, Raposo G, Bonnerot C, Hubert P. BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells. Biol Cell 2006, 98, 491–501.
   PubMed Web of Science ®Google Scholar
• Håkelien AM, Landsverk HB, Robl JM, Skålhegg BS, Collas P. Reprogramming fibroblasts to express T-cell functions using cell extracts. Nat Biotechnol 2002, 20, 460–466.
   PubMed Web of Science ®Google Scholar
• Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol 1985, 101, 942–948.
   PubMed Web of Science ®Google Scholar
• Alais S, Simoes S, Baas D, Lehmann S, Raposo G, Darlix JL, Leblanc P. Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles. Biol Cell 2008, 100, 603–615.
   Google Scholar
• Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A, Rak J. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 2008, 10, 619–624.
   PubMed Web of Science ®Google Scholar
• Alonso R, Rodríguez MC, Pindado J, Merino E, Mérida I, Izquierdo M. Diacylglycerol kinase α regulates the secretion of lethal exosomes bearing fas ligand during activation-induced cell death of T lymphocytes. J Biol Chem 2005, 280, 28439–28450.
   PubMed Web of Science ®Google Scholar
• Al-Nedawi K, Meehan B, Kerbel RS, Allison AC, Rak J. Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci USA 2009, 106, 3794–3799.
   PubMed Web of Science ®Google Scholar
• Bakhti M, Winter C, Simons M. Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles. J Biol Chem 2011, 286, 787–796.
   PubMed Web of Science ®Google Scholar
• Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ, Cooper JM. Lysosomal dysfunction increases exosome-mediated α-synuclein release and transmission. Neurobiol Dis 2011, 42, 360–367.
   PubMed Web of Science ®Google Scholar
• Balaj L, Lessard R, Dai L, Cho YJ, Pomeroy SL, Breakefield XO, Skog J. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun 2011, 2, 180.
   PubMed Web of Science ®Google Scholar
• Booth AM, Fang Y, Fallon JK, Yang JM, Hildreth JE, Gould SJ. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J Cell Biol 2006, 172, 923–935.
   PubMed Web of Science ®Google Scholar
• Castellana D, Zobairi F, Martinez MC, Panaro MA, Mitolo V, Freyssinet JM, Kunzelmann C. Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: A role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res 2009, 69, 785–793.
   PubMed Web of Science ®Google Scholar
• Chairoungdua A, Smith DL, Pochard P, Hull M, Caplan MJ. Exosome release of β-catenin: A novel mechanism that antagonizes Wnt signaling. J Cell Biol 2010, 190, 1079–1091.
   PubMed Web of Science ®Google Scholar
• Atay S, Gercel-Taylor C, Suttles J, Mor G, Taylor DD. Trophoblast-derived exosomes mediate monocyte recruitment and differentiation. Am J Reprod Immunol 2011, 65, 65–77.
   Web of Science ®Google Scholar
• Chavez-Muñoz C, Kilani RT, Ghahary A. Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes. J Cell Physiol 2009, 221, 221–231.
   PubMed Web of Science ®Google Scholar
• Aoki N, Jin-no S, Nakagawa Y, Asai N, Arakawa E, Tamura N, Tamura T, Matsuda T. Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: Redox- and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology 2007, 148, 3850–3862.
   PubMed Web of Science ®Google Scholar
• Aoki N, Yokoyama R, Asai N, Ohki M, Ohki Y, Kusubata K, Heissig B, Hattori K, Nakagawa Y, Matsuda T. Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro. Endocrinology 2010, 151, 2567–2576.
   PubMed Web of Science ®Google Scholar
• Candela ME, Geraci F, Turturici G, Taverna S, Albanese I, Sconzo G. Membrane vesicles containing matrix metalloproteinase-9 and fibroblast growth factor-2 are released into the extracellular space from mouse mesoangioblast stem cells. J Cell Physiol 2010, 224, 144–151.
   PubMed Web of Science ®Google Scholar
• Collino F, Deregibus MC, Bruno S, Sterpone L, Aghemo G, Viltono L, Tetta C, Camussi G. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS ONE 2010, 5, e11803.
   PubMed Web of Science ®Google Scholar
• Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, Collino F, Morando L, Busca A, Falda M, Bussolati B, Tetta C, Camussi G. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009, 20, 1053–1067.
   PubMed Web of Science ®Google Scholar
• Onfelt B, Nedvetzki S, Benninger RK, Purbhoo MA, Sowinski S, Hume AN, Seabra MC, Neil MA, French PM, Davis DM. Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol 2006, 177, 8476–8483.
   PubMed Web of Science ®Google Scholar
• Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM. Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nat Cell Biol 2008, 10, 211–219.
   PubMed Web of Science ®Google Scholar
• Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science 2004, 303, 1007–1010.
   PubMed Web of Science ®Google Scholar
• Watkins SC, Salter RD. Functional connectivity between immune cells mediated by tunneling nanotubules. Immunity 2005, 23, 309–318.
   PubMed Web of Science ®Google Scholar
• Onfelt B, Nedvetzki S, Yanagi K, Davis DM. Cutting edge: Membrane nanotubes connect immune cells. J Immunol 2004, 173, 1511–1513.
   PubMed Web of Science ®Google Scholar
• Koyanagi M, Brandes RP, Haendeler J, Zeiher AM, Dimmeler S. Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: A novel mechanism for cell fate changes? Circ Res 2005, 96, 1039–1041.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Guidolin D, Baluska F, Leo G, Barlow PW, Carone C, Genedani S. A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: Possible relevance for Alzheimer’s disease. Curr Alzheimer Res 2010, 7, 307–322.
   PubMed Web of Science ®Google Scholar
• Domhan S, Ma L, Tai A, Anaya Z, Beheshti A, Zeier M, Hlatky L, Abdollahi A. Intercellular communication by exchange of cytoplasmic material via tunneling nano-tube like structures in primary human renal epithelial cells. PLoS ONE 2011, 6, e21283.
   PubMed Web of Science ®Google Scholar
• Agnati LF, Guidolin D, Leo G, Guescini M, Pizzi M, Stocchi V, Spano PF, Ghidoni R, Ciruela F, Genedani S, Fuxe K. Possible new targets for GPCR modulation: Allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. J Recept Signal Transduct Res 2011, 31, 315–331.
   PubMed Web of Science ®Google Scholar
• Février B, Raposo G. Exosomes: Endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 2004, 16, 415–421.
   PubMed Web of Science ®Google Scholar
• Guescini M, Leo G, Genedani S, Carone C, Pederzoli F, Ciruela F, Guidolin D, Stocchi V, Mantuano M, Borroto-Escuela DO, Fuxe K, Agnati LF. Microvesicle and tunneling nanotube mediated intercellular transfer of G-protein coupled receptors in cell cultures. Exp Cell Res 2012, 318, 603–613.
   PubMed Web of Science ®Google Scholar
• Shai E, Varon D. Development, cell differentiation, angiogenesis–microparticles and their roles in angiogenesis. Arterioscler Thromb Vasc Biol 2011, 31, 10–14.
   PubMed Web of Science ®Google Scholar
• Dunning CJ, Reyes JF, Steiner JA, Brundin P. Can Parkinson’s disease pathology be propagated from one neuron to another? Prog Neurobiol 2011. doi:10.1016/j.pneurobio.2011.11.003
   PubMed Web of Science ®Google Scholar
• Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY, Brundin P. a-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 2011, 121, 715–725.
   PubMed Web of Science ®Google Scholar
• Brundin P, Barker RA, Parmar M. Neural grafting in Parkinson’s disease Problems and possibilities. Prog Brain Res 2010, 184, 265–294.
   PubMed Web of Science ®Google Scholar
• Angot E, Steiner JA, Hansen C, Li JY, Brundin P. Are synucleinopathies prion-like disorders? Lancet Neurol 2010, 9, 1128–1138.
   PubMed Web of Science ®Google Scholar
• Kordower JH, Brundin P. Propagation of host disease to grafted neurons: Accumulating evidence. Exp Neurol 2009, 220, 224–225.
   PubMed Web of Science ®Google Scholar
• Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 2010, 11, 301–307.
   PubMed Web of Science ®Google Scholar
• Steiner JA, Angot E, Brundin P. A deadly spread: Cellular mechanisms of a-synuclein transfer. Cell Death Differ 2011, 18, 1425–1433.
   PubMed Web of Science ®Google Scholar
• Angot E, Brundin P. Dissecting the potential molecular mechanisms underlying α-synuclein cell-to-cell transfer in Parkinson’s disease. Parkinsonism Relat Disord 2009, 15 Suppl 3, S143–S147.
   Google Scholar
• Janowska-Wieczorek A, Wysoczynski M, Kijowski J, Marquez-Curtis L, Machalinski B, Ratajczak J, Ratajczak MZ. Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int J Cancer 2005, 113, 752–760.
   PubMed Web of Science ®Google Scholar
• Deregibus MC, Cantaluppi V, Calogero R, Lo Iacono M, Tetta C, Biancone L, Bruno S, Bussolati B, Camussi G. Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 2007, 110, 2440–2448.
   PubMed Web of Science ®Google Scholar
• Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr Carter BS, Krichevsky AM, Breakefield XO. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008, 10, 1470–1476.
   PubMed Web of Science ®Google Scholar
• Guescini M, Genedani S, Stocchi V, Agnati LF. Astrocytes and glioblastoma cells release exosomes carrying mtDNA. J Neural Transm 2010, 117, 1–4.
   PubMed Web of Science ®Google Scholar
• Guescini M, Guidolin D, Vallorani L, Casadei L, Gioacchini AM, Tibollo P, Battistelli M, Falcieri E, Battistin L, Agnati LF, Stocchi V. C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction. Exp Cell Res 2010, 316, 1977–1984.
   PubMed Web of Science ®Google Scholar
• Alvarez VA, Sabatini BL. Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci 2007, 30, 79–97.
   PubMed Web of Science ®Google Scholar
• Getting PA, Denkin MS. (1985). Tritonia swimming: A model system for integration within rhythmic motor systems. In: Selverston AI. ed. Model neural networks and behaviour. New York: Plenum Press.
   Google Scholar
• Cameron OG. Visceral brain-body information transfer. Neuroimage 2009, 47, 787–794.
   PubMed Web of Science ®Google Scholar
• Craig AD. How do you feel–now? The anterior insula and human awareness. Nat Rev Neurosci 2009, 10, 59–70.
   PubMed Web of Science ®Google Scholar
• Damasio AR, ed 1993). Descartes’ error: Emotion, reason, and the human brain. New York: Putnam.
   Google Scholar
• Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ. Neural systems supporting interoceptive awareness. Nat Neurosci 2004, 7, 189–195.
   PubMed Web of Science ®Google Scholar
• Levine DS. Brain pathways for cognitive-emotional decision making in the human animal. Neural Netw 2009, 22, 286–293.
   PubMed Web of Science ®Google Scholar
• Hagemann D, Waldstein SR, Thayer JF. Central and autonomic nervous system integration in emotion. Brain Cogn 2003, 52, 79–87.
   PubMed Web of Science ®Google Scholar
• Pessoa L. Emergent processes in cognitive-emotional interactions. Dialogues Clin Neurosci 2010, 12, 433–448.
   PubMedGoogle Scholar
• Salzman CD, Fusi S. Emotion, cognition, and mental state representation in amygdala and prefrontal cortex. Annu Rev Neurosci 2010, 33, 173–202.
   PubMed Web of Science ®Google Scholar
• Aradachi H, Honda K, Negoro H, Kubota T. Median preoptic neurones projecting to the supraoptic nucleus are sensitive to haemodynamic changes as well as to rise in plasma osmolality in rats. J Neuroendocrinol 1996, 8, 35–43.
   PubMed Web of Science ®Google Scholar
• Levin BE, Kang L, Sanders NM, Dunn-Meynell AA. Role of neuronal glucosensing in the regulation of energy homeostasis. Diabetes 2006, 55, S122–S130.
   Web of Science ®Google Scholar
• Dean JB, Putnam RW. The caudal solitary complex is a site of central CO(2) chemoreception and integration of multiple systems that regulate expired CO(2). Respir Physiol Neurobiol 2010, 173, 274–287.
   PubMed Web of Science ®Google Scholar
• Melnick IV, Price CJ, Colmers WF. Glucosensing in parvocellular neurons of the rat hypothalamic paraventricular nucleus. Eur J Neurosci 2011, 34, 272–282.
   PubMed Web of Science ®Google Scholar
• Valassi E, Scacchi M, Cavagnini F. Neuroendocrine control of food intake. Nutr Metab Cardiovasc Dis 2008, 18, 158–168.
   PubMed Web of Science ®Google Scholar
• Hoyda TD, Samson WK, Ferguson AV. Adiponectin depolarizes parvocellular paraventricular nucleus neurons controlling neuroendocrine and autonomic function. Endocrinology 2009, 150, 832–840.
   PubMed Web of Science ®Google Scholar
• Hayes MR, De Jonghe BC, Kanoski SE. Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiol Behav 2010, 100, 503–510.
   PubMed Web of Science ®Google Scholar
• Marino JS, Xu Y, Hill JW. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab 2011, 22, 275–285.
   PubMed Web of Science ®Google Scholar
• Lane RD, Wager TD. Introduction to a special issue of Neuroimage on brain-body medicine. Neuroimage 2009, 47, 781–784.
   PubMed Web of Science ®Google Scholar
• Lane RD, Wager TD. The new field of Brain-Body Medicine: What have we learned and where are we headed? Neuroimage 2009, 47, 1135–1140.
   PubMed Web of Science ®Google Scholar
• Damasio A, Meyer K. Behind the looking-glass. Nature 2008, 454, 167–168.
   PubMed Web of Science ®Google Scholar
• Golgi C. (1914). La moderna evoluzione delle dottrine delle conoscenze sulla vita. Milano: Rendiconti Regio Istituto Lombardo, XLVII (1).
   Google Scholar
• Coltheart M. (2001). Assumptions and methods in cognitive neuropsychology.. In: Rapp B. ed. The handbook of cognitive neuropsychology. New York: Psychology Press, 3–21.
   Google Scholar
• Anderson ML, Pessoa L. (2011). Quantifying the diversity of neural activations in individual brain regions.. In: Carlson L, Hölscher C, Shipley T. eds. Proceedings of the 33rd Annual Conference of Cognitive Society. Austin: Cognitive Science Society, 2421–2426.
   Google Scholar
• Taylor J. ed. (1932). Selected Writings of John Hughlings Jackson. London: Hodder & Stoughton, 2.
   Google Scholar
• Capaday C. The integrated nature of motor cortical function. Neuroscientist 2004, 10, 207–220.
   PubMed Web of Science ®Google Scholar
• Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, Ju S, Mu J, Zhang L, Steinman L, Miller D, Zhang HG. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther 2011, 19, 1769–1779.
   PubMed Web of Science ®Google Scholar
• Thayer JF, Brosschot JF. Psychosomatics and psychopathology: Looking up and down from the brain. Psychoneuroendocrinology 2005, 30, 1050–1058.
   PubMed Web of Science ®Google Scholar
• Lane RD, McRae K, Reiman EM, Chen K, Ahern GL, Thayer JF. Neural correlates of heart rate variability during emotion. Neuroimage 2009, 44, 213–222.
   PubMed Web of Science ®Google Scholar
• Zoli M, Zini I, Agnati LF, Guidolin D, Ferraguti F, Fuxe K. Aspects of neural plasticity in the central nervous system-I. Computer-assisted image analysis methods. Neurochem Int 1990, 16, 383–418.
   PubMed Web of Science ®Google Scholar
• Guidolin D, Albertin G, Guescini M, Fuxe K, Agnati LF. Central nervous system and computation. Q Rev Biol 2011, 86, 265–285.
   PubMed Web of Science ®Google Scholar