A macromolecular trafficking complex composed of β₂-adrenergic receptors, A-Kinase Anchoring Proteins and L-type calcium channels

References

• Sutton KG, McRory JE, Guthrie H, et al. P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A. Nature 1999;401:800–4
   Google Scholar
• Wheeler DB, Randall A, Tsien RW. Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science 1994;264:107–11
   PubMed Web of Science ®Google Scholar
• Dunlap K, Luebke JI, Turner TJ. Exocytotic Ca2+ channels in mammalian central neurons. Trends Neurosci 1995;18:89–98
   PubMed Web of Science ®Google Scholar
• Dolmetsch RE, Pajvani U, Fife K, et al. Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 2001;294:333–9
   PubMed Web of Science ®Google Scholar
• Benitah JP, Alvarez JL, Gómez AM. L-type Ca(2+) current in ventricular cardiomyocytes. J Mol Cell Cardiol 2010;48:26–36
   PubMed Web of Science ®Google Scholar
• Bodi I, Mikala G, Koch SE, et al. The L-type calcium channel in the heart: the beat goes on. J Clin Invest. 2005;115:3306–17
   PubMed Web of Science ®Google Scholar
• Tsien RW, Ellinor PT, Horne WA. Molecular diversity of voltage-dependent Ca2+ channels. Trends Pharmacol Sci 1991;12:349–54
   PubMed Web of Science ®Google Scholar
• Lipscombe D, Pan JQ, Gray AC. Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1. Mol Neurobiol 2002;26:21–44
   PubMed Web of Science ®Google Scholar
• Perez Reyes E. Molecular physiology of T-type channels Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev 2003;83:117–61
   Google Scholar
• Fox AP, Nowycky MC, Tsien RW. Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol 1987;394:149–72
   PubMed Web of Science ®Google Scholar
• Zhang JF, Randall AD, Ellinor PT, et al. Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology 1993;32:1075–88
   PubMed Web of Science ®Google Scholar
• Catterall WA. Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol 2000;16:521–55
   PubMed Web of Science ®Google Scholar
• Dolphin AC. Beta subunits of voltage-gated calcium channels. J Bioenerg Biomembr 2003;35:599–620
   PubMed Web of Science ®Google Scholar
• Arikkath J, Campbell KP. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol 2003;13:298–307
   PubMed Web of Science ®Google Scholar
• Perez-Reyes E, Cribbs LL, Daud A, et al. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 1998;391:896–900
   PubMed Web of Science ®Google Scholar
• Cribbs LL, Lee JH, Yang J, et al. Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circulation Res 1998;83:103–9
   PubMed Web of Science ®Google Scholar
• Lee JH, Daud AN, Cribbs LL, et al. Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci 1999;19:1912–21
   PubMed Web of Science ®Google Scholar
• McRory JE, Santi CM, Hamming KS, et al. Molecular and functional characterization of a family of rat brain T-type calcium channels. J Biol Chem 2001;276:3999–4011. (Erratum in: J Biol Chem 2001;276:30571–4.)
   PubMed Web of Science ®Google Scholar
• Bourinet E, Soong TW, Sutton K, et al. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat Neurosci 1999;2:407–15
   PubMed Web of Science ®Google Scholar
• Williams ME, Brust PF, Feldman DH, et al. Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel. Science 1992;257:389–95
   PubMed Web of Science ®Google Scholar
• Dubel SJ, Starr TV, Hell J, et al. Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel. Proc Natl Acad Sci USA 1992;89:5058–62
   PubMed Web of Science ®Google Scholar
• Soong TW, Stea A, Hodson CD, et al. Structure and functional expression of a member of the low voltage-activated calcium channel family. Science 1993;260:1133–6
   PubMed Web of Science ®Google Scholar
• Williams ME, Marubio LM, Deal CR, et al. Structure and functional characterization of neuronal alpha 1E calcium channel subtypes. J Biol Chem 1994;269:22347–57
   PubMedGoogle Scholar
• Tottene A, Moretti A, Pietrobon D. Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons. J Neurosci 1996;16:6353–63
   PubMed Web of Science ®Google Scholar
• Williams ME, Feldman DH, McCue AF, et al. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. Neuron 1992;8:71–84
   Google Scholar
• Stea A, Dubel SJ, Pragnell M, et al. Functional properties of a neuronal class C L-type calcium channel. Neuropharmacology 1993;32:1103–16
   Google Scholar
• Tomlinson WJ, Stea A, Bourinet E, et al. Functional properties of a neuronal class C L-type calcium channel. Neuropharmacology 1993;32:1117–26
   Google Scholar
• McRory JE, Hamid J, Doering CJ, et al. The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. J Neurosci 2004;24:1707–18
   PubMedGoogle Scholar
• Seisenberger C, Specht V, Welling A, et al. Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem 2000;275:39193–9
   PubMed Web of Science ®Google Scholar
• Mangoni ME, Couette B, Bourinet E, et al. Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity. Proc Natl Acad Sci USA 2003;100:5543–8
   PubMed Web of Science ®Google Scholar
• Splawski I, Timothy KW, Sharpe LM, et al. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 2004;119:19–31
   PubMed Web of Science ®Google Scholar
• Hell JW. Beta-adrenergic regulation of the L-type Ca2+ channel Ca(V)1.2 by PKA rekindles excitement. Sci Signal 2010;3:pe33
   Google Scholar
• Kapur A, Yeckel MF, Gray R, et al. L-Type calcium channels are required for one form of hippocampal mossy fiber LTP. J Neurophysiol 1998;79:2181–90
   PubMed Web of Science ®Google Scholar
• McDonald TF, Pelzer S, Trautwein W, Pelzer DJ. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 1994;74:365–507
   PubMed Web of Science ®Google Scholar
• Skeberdis VA, Jurevicius J, Fischmeister R. Beta-2 adrenergic activation of L-type Ca++ current in cardiac myocytes. J Pharmacol Exp Ther 1997;283:452–61
   PubMed Web of Science ®Google Scholar
• Brodde OE, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev 1999;51:651–90
   PubMed Web of Science ®Google Scholar
• Bodi I, Mikala G, Koch SE, et al. The L-type calcium channel in the heart: the beat goes on. J Clin Invest 2005;115:3306–17
   PubMed Web of Science ®Google Scholar
• Gao T, Yatani A, Dell'Acqua ML, et al. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 1997;19:185–96
   PubMed Web of Science ®Google Scholar
• Devic E, Xiang Y, Gould D, Kobilka B. Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Mol Pharmacol 2001;60:577–83
   PubMed Web of Science ®Google Scholar
• Chen-Izu Y, Xiao RP, Izu LT, et al. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels. Biophys J 2000;79:2547–56
   PubMed Web of Science ®Google Scholar
• Zhang ZS, Cheng HJ, Onishi K, et al. Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart. J Pharmacol Exp Ther 2005;315:1203–11
   PubMed Web of Science ®Google Scholar
• Fuller MD, Emrick MA, Sadilek M, et al. Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci Signal 2010;28:141
   Google Scholar
• Davare MA, Avdonin V, Hall DD, et al. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science 2001;293:98–101
   PubMed Web of Science ®Google Scholar
• Hall DD, Davare MA, Shi M, et al. Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons. Biochemistry 2007;46:1635–46
   Google Scholar
• Oliveria SF, Dell'Acqua ML, Sather WA. AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron 2007;55:261–75
   Google Scholar
• Hall DD, Feekes JA, Arachchige Don AS, et al. Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Biochemistry 2006;45:3448–59
   PubMed Web of Science ®Google Scholar
• Malbon CC. A-kinase anchoring proteins: trafficking in G-protein-coupled receptors and the proteins that regulate receptor biology. Curr Opin Drug Discov Dev 2007;10:573–9
   Google Scholar
• Dai S, Hall DD, Hell JW. Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev 2009;89:411–52
   PubMed Web of Science ®Google Scholar
• Gray PC, Tibbs VC, Catterall WA, Murphy BJ. Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels. J Biol Chem 1997;272:6297–302
   PubMed Web of Science ®Google Scholar
• Marx SO, Reiken S, Hisamatsu Y, et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 2000;101:365–76
   PubMed Web of Science ®Google Scholar
• Fan G, Shumay E, Wang H, Malbon CC. The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization. J Biol Chem 2001;276:24005–14
   PubMed Web of Science ®Google Scholar
• Fraser ID, Tavalin SJ, Lester LB, et al. A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events. Embo J 1998;17:2261–72
   PubMed Web of Science ®Google Scholar
• Fraser ID, Cong M, Kim J, et al. Assembly of an A-kinase anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr Biol 2000;10:409–12
   PubMed Web of Science ®Google Scholar
• Malbon CC, Tao J, Wang HY. AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes. Biochem J 2004;379:1–9
   PubMed Web of Science ®Google Scholar
• Bauman AL, Soughayer J, Nguyen BT, et al. Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell 2006;23:925–31
   PubMedGoogle Scholar
• Hulme JT, Lin TW, Westenbroek RE, et al. Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Proc Natl Acad Sci USA 2003;100:13093–8
   PubMed Web of Science ®Google Scholar
• Davare MA, Avdonin V, Hall DD, et al. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science 2001;293:98–101
   PubMed Web of Science ®Google Scholar
• Gao T, Yatani A, Dell'Acqua ML, et al. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 1997;19:185–96
   PubMed Web of Science ®Google Scholar
• Fraser ID, Tavalin SL, Lester LB, et al. A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events. Embo J 1998;17:2261–72
   PubMed Web of Science ®Google Scholar
• Altier C, Dubel SJ, Barrère C, et al. Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J Biol Chem 2002;277:33598–603
   Google Scholar
• Altier C, Dubel SJ, Barrere C, et al. Channels (Austin) 2012;6:157–65
   Google Scholar