The signaling pathway of NADPH oxidase and its role in glomerular diseases

References

• Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 2004;4:181–9
   PubMed Web of Science ®Google Scholar
• Vostálová J, Galandáková A, Strebl P, et al. Oxidative stress in kidney disease patients. Vnitr Lek 2012;58:202-7
   Google Scholar
• Takeya R, Sumimoto H. Regulation of novel superoxide-producing NADPH oxidases. Antioxid Redox Signal 2006;8:1523–32
   PubMed Web of Science ®Google Scholar
• Gorin Y, Block K. Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med 2013;61:130--42
   Google Scholar
• Barnes JL, Gorin Y. Myofibroblast differentiation during fibrosis: role of NADPH oxidases. Kidney Int 2011;79:944–56
   PubMed Web of Science ®Google Scholar
• Djamali A, Reese S, Hafez O, et al. Nox2 is a mediator of chronic CsA nephrotoxicity. Am J Transplant 2012;12:1997–2007
   PubMed Web of Science ®Google Scholar
• You YH, Okada S, Ly S, et al. Role of Nox2 in diabetic kidney disease. Am J Physiol Renal Physiol. 2013;304:F840–8
   Google Scholar
• Nlandu Khodo S, Dizin E, Sossauer G, et al. NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury. J Am Soc Nephrol 2012;23:1967–76
   PubMed Web of Science ®Google Scholar
• Kim YH, Hwang JH, Noh JR, et al. Prevention of salt-induced renal injury by activation of NADPH: quinone oxidoreductase 1, associated with NADPH oxidase. Free Radic Biol Med 2012;52:880–8
   PubMedGoogle Scholar
• Zhou TB. Signaling pathways of PAX2 and its role in renal interstitial fibrosis and glomerulosclerosis. J Recept Signal Transduct Res 2012;32:285–9
   PubMed Web of Science ®Google Scholar
• Zhou TB, Qin YH. The potential mechanism for the different expressions of gelatinases induced by all-trans retinoic acid in different cells. J Recept Signal Transduct Res 2012;32:129–33
   PubMed Web of Science ®Google Scholar
• Torres MA, Morales J, Sánchez-Rodríguez C, et al. Functional interplay between Arabidopsis NADPH oxidases and heterotrimeric G protein. Mol Plant Microbe Interact 2013;26:686–94
   PubMed Web of Science ®Google Scholar
• Shao D, Segal AW, Dekker LV. Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin. Int J Biochem Cell Biol 2010;42:1736–43
   PubMedGoogle Scholar
• Park HS, Park D, Bae YS. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. Biochem Biophys Res Commun 2006;339:985–90
   PubMedGoogle Scholar
• Bánfi B, Tirone F, Durussel I, et al. Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem 2004;279:18583–91
   PubMed Web of Science ®Google Scholar
• Wientjes FB, Reeves EP, Soskic V, et al. The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. Biochem Biophys Res Commun 2001;289:382–8
   PubMedGoogle Scholar
• Lee JH, Joo JH, Kim J, et al. Interaction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells. Cardiovasc Res 2013;99:483–93
   PubMed Web of Science ®Google Scholar
• Karupiah G, Hunt NH, King NJ, et al. NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response. Rev Immunogenet 2000;2:387–415
   PubMedGoogle Scholar
• Ma C, Wang N, Detre C, et al. Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J Biol Chem 2012;287:18359–65
   PubMed Web of Science ®Google Scholar
• Park KJ, Lee CH, Kim A, et al. Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death. J Biol Chem 2012;287:3313–25
   PubMed Web of Science ®Google Scholar
• Kuwano Y, Kawahara T, Yamamoto H, et al. Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells. Am J Physiol Cell Physiol 2006;290:C433–43
   PubMed Web of Science ®Google Scholar
• Gianni D, Diaz B, Taulet N, et al. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal 2009;2:ra54
   Google Scholar
• Taura M, Miyano K, Minakami R, et al. A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase. Biochem J 2009;419:329–38
   PubMedGoogle Scholar
• Kerkhoff C, Nacken W, Benedyk M, et al. The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2. FASEB J 2005;19:467–9
   PubMed Web of Science ®Google Scholar
• Kusumoto K, Kawahara T, Kuwano Y, et al. Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 orapoptosis of guinea pig gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol 2005;288:G300–7
   PubMedGoogle Scholar
• Lopes LR, Dagher MC, Gutierrez A, et al. Phosphorylated p40PHOX as a negative regulator of NADPH oxidase. Biochemistry 2004;43:3723–30
   PubMed Web of Science ®Google Scholar
• Hordijk PL. Regulation of NADPH oxidases: the role of Rac proteins. Circ Res 2006;98:453–62
   PubMed Web of Science ®Google Scholar
• George A, Pushkaran S, Konstantinidis DG, et al. Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease. Blood 2013;121:2099–107
   PubMedGoogle Scholar
• Gil Lorenzo AF, Bocanegra V, Benardon ME, et al. Hsp70 regulation on Nox4/p22phox and cytoskeletal integrity as an effect of losartan in vascular smooth muscle cells. Cell Stress Chaperones 2013. [Epub ahead of print]
   Google Scholar
• Guiñazú N, Carrera-Silva EA, Becerra MC, et al. Induction of NADPH oxidase activity and reactive oxygen species production by a single Trypanosoma cruzi antigen. Int J Parasitol 2010;40:531–8
   Google Scholar
• Alkan N, Davydov O, Sagi M, et al. Ammonium secretion by Colletotrichum coccodes activates host NADPH oxidase activity enhancing host cell death and fungal virulence in tomato fruits. Mol Plant Microbe Interact 2009;22:1484–91
   PubMed Web of Science ®Google Scholar
• Paraje MG, Correa SG, Albesa I, et al. Lipase of Candida albicans induces activation of NADPH oxidase and L-arginine pathways on resting and activated macrophages. Biochem Biophys Res Commun 2009;390:263–8
   PubMed Web of Science ®Google Scholar
• Cigerci IH, Fidan AF, Konuk M, et al. The protective potential of Yucca schidigera (Sarsaponin 30) against nitrite-induced oxidative stress in rats. J Nat Med 2009;63:311–17
   PubMed Web of Science ®Google Scholar
• Qin J, Xie YY, Huang L, et al. Fluorofenidone inhibits NADPH oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton) 2013;18:690--9
   Google Scholar
• Edderkaoui M, Nitsche C, Zheng L, et al. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem 2011;286:7779–87
   PubMedGoogle Scholar
• Cristóvão AC, Barata J, Je G, et al. PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. Biochem Biophys Res Commun 2013;437:380–5
   PubMedGoogle Scholar
• Choi SR, Roh DH, Yoon SY, et al. Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats. Pharmacol Res 2013;74C:56–67
   Google Scholar
• Fu Y, Zhang Y, Wang Z, et al. Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy. Am J Nephrol 2010;32:581–9
   PubMed Web of Science ®Google Scholar
• Chen F, Qian LH, Deng B, et al. Resveratrol protects vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress. CNS Neurosci Ther 2013;19:675--81
   Google Scholar
• Li CY, Deng YL, Sun BH. Taurine protected kidney from oxidative injury through mitochondrial-linked pathway in a rat model of nephrolithiasis. Urol Res 2009;37:211–20
   PubMedGoogle Scholar
• Ford BM, Eid AA, Gooz M, et al. ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice. Am J Physiol Renal Physiol 2013;305:323--32
   Google Scholar
• Sokolovska A, Becker CE, Ip WK, et al. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol 2013;14:543–53
   PubMed Web of Science ®Google Scholar
• Zhou L, Dong H, Huang Y, et al. Hu-Lu-Ba-Wan attenuates diabetic nephropathy in type 2 diabetic rats through PKC-α/NADPH oxidase signaling pathway. Evid Based Complement Alternat Med 2013;504642:1--10
   Google Scholar
• Lee IT, Shih RH, Lin CC, et al. Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells. Cell Commun Signal 2012;10:33
   PubMed Web of Science ®Google Scholar
• Zhang C, Yi F, Xia M, et al. NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. Antioxid Redox Signal 2010;13:975–86
   PubMed Web of Science ®Google Scholar
• Plesková M, Beck KF, Behrens MH, et al. Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. FASEB J 2006;20:139–41
   PubMedGoogle Scholar
• Yi F, Zhang AY, Janscha JL, et al. Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. Kidney Int 2004;66:1977–87
   Google Scholar
• Miyata K, Rahman M, Shokoji T, et al. Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells. J Am Soc Nephrol 2005;16:2906–12
   PubMed Web of Science ®Google Scholar
• Wang Z, Wei X, Zhang Y, et al. NADPH oxidase-derived ROS contributes to upregulation of TRPC6 expression in puromycin aminonucleoside-induced podocyte injury. Cell Physiol Biochem 2009;24:619–26
   PubMedGoogle Scholar
• Lelli A, Gervais A, Colin C, et al. The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Glia 2013;61:1542--55
   Google Scholar
• Nadworny AS, Guruju MR, Poor D, et al. Nox2 and Nox4 influence neonatal C-kit+ cardiac precursor cell status and differentiation. Am J Physiol Heart Circ Physiol 2013;305:829--42
   Google Scholar
• Chan SL, Baumbach GL. Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles. Front Physiol 2013;4:133
   PubMedGoogle Scholar
• Topchiy E, Panzhinskiy E, Griffin WS, et al. Nox4-generated superoxide drives angiotensin II-induced neural stem cell pProliferation. Dev Neurosci 2013;35:293--305
   Google Scholar
• Selemidis S, Seow HJ, Broughton BR, et al. Nox1 oxidase suppresses influenza a virus- induced lung inflammation and oxidative stress. PLoS ONE 2013;8:e60792
   Google Scholar
• Santos CX, Tanaka LY, Wosniak J, et al. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 2009;11:2409–27
   PubMed Web of Science ®Google Scholar
• Eid AA, Ford BM, Block K, et al. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J Biol Chem 2010;285:37503–12
   PubMed Web of Science ®Google Scholar
• Abais JM, Zhang C, Xia M, et al. NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia. Antioxid Redox Signal 2013;18:1537–48
   PubMed Web of Science ®Google Scholar
• Yan Q, Gao K, Chi Y, et al. NADPH oxidase-mediated upregulation of connexin 43 contributes to podocyte injury. Free Radic Biol Med 2012;53:1286–97
   PubMed Web of Science ®Google Scholar
• Gorin Y, Block K, Hernandez J, et al. Nox4 NADPH oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem 2005;280:39616–26
   PubMed Web of Science ®Google Scholar
• Gorin Y, Ricono JM, Kim NH, et al. Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Am J Physiol Renal Physiol 2003;285:F219–29
   PubMedGoogle Scholar
• Dikalova AE, Góngora MC, Harrison DG, et al. Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol 2010;299:H673–9
   PubMed Web of Science ®Google Scholar
• Bao JX, Jin S, Zhang F, et al. Activation of membrane NADPH oxidase associated with lysosome-targeted acid sphingomyelinase in coronary endothelial cells. Antioxid Redox Signal 2010;12:703–12
   PubMed Web of Science ®Google Scholar
• Altintas R, Polat A, Vardi N, et al. The protective effects of apocynin on kidney damage caused by renal ischemia/reperfusion. J Endourol 2013;27:617–24
   PubMed Web of Science ®Google Scholar
• Song E, Jaishankar GB, Saleh H, et al. Chronic granulomatous disease: a review of the infectious and inflammatory complications. Clin Mol Allergy 2011;9:10
   PubMedGoogle Scholar
• Liu GC, Fang F, Zhou J, et al. Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse. Diabetologia 2012;55:2522–32
   PubMed Web of Science ®Google Scholar
• Kinugasa S, Tojo A, Sakai T, et al. Selective albuminuria via podocyte albumin transport in puromycin nephrotic rats is attenuated by an inhibitor of NADPH oxidase. Kidney Int 2011;80:1328–38
   PubMed Web of Science ®Google Scholar
• Barnes JL, Gorin Y. Myofibroblast differentiation during fibrosis: role of NADPH oxidases. Kidney Int 2011;79:944–56
   PubMed Web of Science ®Google Scholar
• Nagasu H, Satoh M, Kuwabara A, et al. Renal denervation reduces glomerular injury by suppressing NAD(P)H oxidase activity in Dahl salt-sensitive rats. Nephrol Dial Transplant 2010;25:2889–98
   PubMedGoogle Scholar
• Zhou LL, Hou FF, Wang GB, et al. Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanisms. Kidney Int 2009;76:1148–60
   PubMed Web of Science ®Google Scholar
• Thallas-Bonke V, Thorpe SR, Coughlan M, et al. Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathythrough a protein kinase C-alpha-dependent pathway. Diabetes 2008;57:460–9
   PubMed Web of Science ®Google Scholar
• Fujii M, Inoguchi T, Maeda Y, et al. Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. Kidney Int 2007;72:473–80
   PubMed Web of Science ®Google Scholar
• Eid AA, Ford BM, Bhandary B, et al. Mammalian target of rapamycin regulates nox4-mediated podocyte depletion in diabetic renal injury. Diabetes 2013;62:2935–47
   PubMed Web of Science ®Google Scholar
• Persson P, Hansell P, Palm F. NADPH oxidase inhibition reduces tubular sodium transport and improves kidney oxygenation in diabetes. Am J Physiol Regul Integr Comp Physiol 2012;302:R1443–9
   Google Scholar
• Zhang C, Xia M, Boini KM, et al. Epithelial-to-mesenchymal transition in podocytes mediated by activation of NADPH oxidase in hyperhomocysteinemia. Pflugers Arch 2011;462:455–67
   PubMedGoogle Scholar
• Babelova A, Avaniadi D, Jung O, et al. Role of Nox4 in murine models of kidney disease. Free Radic Biol Med 2012;53:842–53
   PubMed Web of Science ®Google Scholar
• Ahmad A, Mondello S, Di Paola R, et al. Protective effect of apocynin, a NADPH-oxidase inhibitor, against contrast-induced nephropathy in the diabetic rats: a comparison with n-acetylcysteine. Eur J Pharmacol 2012;674:397–406
   PubMed Web of Science ®Google Scholar
• Fujita H, Fujishima H, Morii T, et al. Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice. Hypertens Res 2012;35:213–20
   PubMedGoogle Scholar
• Dorsam G, Taher MM, Valerie KC, et al. Diphenyleneiodium chloride blocks inflammatory cytokine-induced up-regulation of group IIA phospholipase A(2) in rat mesangial cells. J Pharmacol Exp Ther 2000;292:271–9
   PubMedGoogle Scholar