References
- Bufill JA. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 1990;113:779–88
- Iacopetta B. Are there two sides to colorectal cancer?. Int J Cancer 2002;101:403–8
- Gervaz P, Bucher P, Morel P. Two colons – two cancers: paradigm shift and clinical implications. J Surg Oncol 2004;88:261–6
- Prewett MC, Hooper AT, Bassi R, et al. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res 2002;8:994–1003
- Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004;351:337–45
- Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759–67
- Rougier P, Mitry E. Epidemiology, treatment and chemoprevention in colorectal cancer. Ann Oncol 2003; Suppl 2;ii3–5
- Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11–25
- Mulrooney J, Foley K, Vineberg S, et al. Phosphorylation of the β1 integrin cytoplasmic domain: toward an understanding of function and mechanism. Exp Cell Res 2000;258:332–41
- Hannigan GE, Dedhar S. Protein kinase mediators of integrin signal transduction. J Mol Med 1997;75:35–44
- Oneyama C, Morii E, Okuzaki D, et al. MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression. Oncogene 2012;29:1623–35
- Tang MC, Chan LC, Yeh YC, et al. Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway. Cancer Lett 2011;308:162–71
- Albasri A, Al-Ghamdi S, Fadhil W, et al. Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer. Oncogene 2011;30:2997–3002
- Bravou V, Klironomos G, Papadaki E, et al. ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. J Pathol 2006;208:91–9
- Kaiser R, Friedrich D, Chavakis E, et al. Effect of hypoxia on integrin-mediated adhesion of endothelial progenitor cells. J Cell Mol Med 2012;16:2387–93
- Abboud ER, Coffelt SB, Figueroa YG, et al. Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells. Int J Oncol 2007;30:113–22
- Ma C, Li Y, Ma J, et al. Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension. Hypertension 2011;58:679–88
- Childs AC, Phaneuf SL, Dirks AJ, et al. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio. Cancer Res 2002;62:4592–8
- Li L, Lu Y. Inhibition of hypoxia-induced cell motility by p16 in MDA-MB-231 breast cancer cells. J Cancer 2010;1:126–35
- Zhu P, Ning Y, Yao L, et al. The proliferation, apoptosis, invasion of endothelial-like epithelial ovarian cancer cells induced by hypoxia. J Exp Clin Cancer Res 2010;29:124
- Zhu J, Pan X, Zhang Z, et al. Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells. Cell Signal 2012;24:1323–32
- Kucharzewska P, Christianson HC, Welch JE, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A 2013;110:7312–7
- Huang S, Peng L, Tang Y, et al. Hypoxia of PC-3 prostate cancer cells enhances migration and vasculogenesis in vitro of bone marrow-derived endothelial progenitor cells by secretion of cytokines. Oncol Rep 2013;29:2369–77
- Brahimi-Horn MC, Chiche J, Pouyssegur J. Hypoxia and cancer. J Mol Med 2007;85:1301–7
- Kim KR, Moon HE, Kim KW. Hypoxia-induced angiogenesis in human hepatocellular carcinoma. J Mol Med 2002;80:703–14
- Polacheck WJ, Zervantonakis IK, Kamm RD. Tumor cell migration in complex microenvironments. Cell Mol Life Sci 2013;70:1335–56
- Jung SH, Kang KD, Ji D, et al. The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes. Neurochem Int 2008;53:325–37
- Correa F, Soto V, Zazueta C. Mitochondrial permeability transition relevance for apoptotic triggering in the post-ischemic heart. Int J Bio-Chem Cell Biol 2007;39:787–98