GPR39-1b, the 5-transmembrane isoform of GPR39 interacts with neurotensin receptor NTSR1 and modifies its function

References

• Holst B, Holliday ND, Bach A, et al. Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem 2004;279:53806–17
   PubMed Web of Science ®Google Scholar
• Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656–60
   PubMed Web of Science ®Google Scholar
• Vincent JP, Mazella J, Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol Sci 1999;20:302–9
   PubMed Web of Science ®Google Scholar
• McKee KK, Tan CP, Palyha OC, et al. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics 1997;46:426–34
   PubMed Web of Science ®Google Scholar
• Petersen PS, Jin C, Madsen AN, et al. Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. FASEB J 2011;25:3803–14
   Google Scholar
• Verhulst PJ, Lintermans A, Janssen S, et al. GPR39, a receptor of the ghrelin receptor family, plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity. J Neuroendocrinol 2011;23:490–500
   PubMed Web of Science ®Google Scholar
• Egerod KL, Jin C, Petersen PS, et al. β-Cell specific overexpression of GPR39 protects against streptozotocin-induced hyperglycemia. Int J Endocrinol 2011;2011:401258
   PubMed Web of Science ®Google Scholar
• Tremblay F, Richard AM, Will S, et al. Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo. Endocrinology 2009;150:2586–95
   Google Scholar
• Holst B, Egerod KL, Jin C, et al. G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology 2009;150:2577–85
   Google Scholar
• Moechars D, Depoortere I, Moreaux B, et al. Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse. Gastroenterology 2006;131:1131–41
   PubMedGoogle Scholar
• Depoortere I. GI functions of GPR39: novel biology. Curr Opin Pharmacol 2012;12:647–52
   PubMed Web of Science ®Google Scholar
• Popovics P, Stewart AJ. GPR39: a Zn(2+)-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions. Cell Mol Life Sci 2011;68:85–95
   Google Scholar
• Egerod KL, Holst B, Petersen PS, et al. GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. Mol Endocrinol 2007;21:1685–98
   PubMed Web of Science ®Google Scholar
• Holst B, Egerod KL, Schild E, et al. GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 2007;148:13–20
   PubMed Web of Science ®Google Scholar
• Yasuda S, Miyazaki T, Munechika K, et al. Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum. J Recept Signal Transduct 2007;27:235–46
   Web of Science ®Google Scholar
• Storjohann L, Holst B, Schwartz TW. Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. FEBS Lett 2008;582:2583–8
   Google Scholar
• Assaf SY, Chung SH. Release of endogenous Zn2+ from brain tissue during activity. Nature 1984;308:734–6
   PubMed Web of Science ®Google Scholar
• Howell GA, Welch MG, Frederickson CJ. Stimulation-induced uptake and release of zinc in hippocampal slices. Nature 1984;308:736–8
   PubMed Web of Science ®Google Scholar
• Mary S, Fehrentz JA, Damian M, et al. Heterodimerization with its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs. J Biol Chem 2013;288:24656–65
   Google Scholar
• Hwang JR, Baek MW, Sim J, et al. Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. Biochem Biophys Res Commun 2010;391:1007–13
   Google Scholar
• Jensen AA, Hansen JL, Sheikh SP, Bräuner-Osborne H. Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). Eur J Biochem 2002;269:5076–87
   PubMedGoogle Scholar
• Fitzgerald LR, Mannan IJ, Dytko GM, et al. Measurement of responses from Gi-, Gs-, or Gq-coupled receptors by a multiple response element/cAMP response element-directed reporter assay. Anal Biochem 1999;275:54–61
   Google Scholar
• Levoye A, Dam J, Ayoub MA, et al. Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep 2006;7:1094–8
   PubMed Web of Science ®Google Scholar
• Tanaka K, Masu M, Nakanishi S. Structure and functional expression of the cloned rat neurotensin receptor. Neuron 1990;4:847–54
   PubMed Web of Science ®Google Scholar
• Thangaraju M, Cresci GA, Liu K, et al. GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Res 2009;69:2826–32
   PubMed Web of Science ®Google Scholar
• Bagher AM, Laprairie RB, Kelly ME, Denovan-Wright EM. Co-expression of the human cannabinoid receptor coding region splice variants (hCB1) affects the function of hCB1 receptor complexes. Eur J Pharmacol 2013;721:341-54
   Google Scholar
• Watson SJ, Brown AJ, Holliday ND. Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol 2012;81:631–42
   PubMed Web of Science ®Google Scholar
• Field M, Sheerin HE, Henderson A, Smith PL. Catecholamine effects on cyclic AMP levels and ion secretion in rabbit ileal mucosa. Am J Physiol 1975;229:86–92
   Google Scholar
• Brown DR, Treder BG. Neurohormonal regulation of ion transport in the porcine distal jejunum. Actions of neurotensin and its natural homologs. J Pharmacol Exp Ther 1989;249:348–57
   PubMedGoogle Scholar
• Mandel KG, Dharmsathaphorn K, McRoberts JA. Characterization of a cyclic AMP-activated Cl-transport pathway in the apical membrane of a human colonic epithelial cell line. J Biol Chem 1986;261:704–12
   PubMedGoogle Scholar
• Riegler M, Castagliuolo I, Wang C, et al. Neurotensin stimulates Cl(−) secretion in human colonic mucosa in vitro: role of adenosine. Gastroenterology 2000;119:348–57
   Google Scholar
• Chalon P, Vita N, Kaghad M, et al. Molecular cloning of a levocabastine-sensitive neurotensin binding site. FEBS Lett 1996;386:91–4
   PubMed Web of Science ®Google Scholar
• Calam J, Unwin R, Peart WS. Neurotensin stimulates defaecation. Lancet 1983;1:737–8
   Google Scholar
• Blackburn AM, Fletcher DR, Bloom SR, et al. Effect of neurotensin on gastric function in man. Lancet 1980;1:987–9
   PubMed Web of Science ®Google Scholar
• Ishitobi Y, Akiyoshi J, Honda S, et al. Administration of antisense DNA for GPR39-1b causes anxiolytic-like responses and appetite loss in rats. Neurosci Res 2011;72:257–62
   Google Scholar