References
- Bader M, Ganten D. Regulation of renin: new evidence from cultured cells and genetically modified mice. J Mol Med 2000;78:130–9
- Chen L, Kim SM, Oppermann M, et al. Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsalpha in juxtaglomerular cells. Am J Physiol Renal Physiol 2007;292:F27–37
- Desch M, Schubert T, Schreiber A, et al. PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression. Mol Endocrinol 2010;24:2139–51
- Pan L, Gross KW. Transcriptional regulation of renin: an update. Hypertension 2005;45:3–8
- Horiuchi M, Pratt RE, Nakamura N, Dzau VJ. Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. J Clin Invest 1993;92:1805–11
- Tamura K, Chen YE, Horiuchi M, et al. LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. Proc Natl Acad Sci USA 2000;97:8513–8
- Morello F, de Boer RA, Steffensen KR, et al. Liver X receptors alpha and beta regulate renin expression in vivo. J Clin Invest 2005;115:1913–22
- Glenn ST, Jones CA, Gross KW, Pan L. Control of renin [corrected] gene expression. Pflugers Arch 2013;465:13–21
- Shimizu T, Oishi T, Omori A, et al. Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination. Mol Cell Biol 2005;25:2938–45
- Tanimoto K, Sugiura A, Kanafusa S, et al. A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation. J Clin Invest 2008;118:1006–16
- Siegal ML, Hartl DL. Transgene Coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics 1996;144:715–26
- Siegal ML, Hartl DL. An experimental test for lineage-specific position effects on alcohol dehydrogenase (Adh) genes in Drosophila. Proc Natl Acad Sci USA 1998;95:15513–18
- Petrovic N, Black TA, Fabian JR, et al. Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem 1996;271:22499–505
- Yan Y, Jones CA, Sigmund CD, et al. Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res 1997;81:558–66
- Shi Q, Black TA, Gross KW, Sigmund CD. Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circ Res 1999;85:479–88
- Pan L, Black TA, Shi Q, et al. Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem 2001;276:45530–8
- Shi Q, Gross KW, Sigmund CD. Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem 2001;276:3597–603
- Liu X, Huang X, Sigmund CD. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circ Res 2003;92:1033–40
- Weatherford ET, Liu X, Sigmund CD. Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6. Am J Physiol Renal Physiol 2012;302:F1025–33
- Pan L, Glenn ST, Jones CA, et al. Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3. Biochim Biophys Acta 2003;1625:280–90
- Steege A, Fahling M, Paliege A, et al. Wilms' tumor protein (-KTS) modulates renin gene transcription. Kidney Int 2008;74:458–66
- Field LJ, Philbrick WM, Howles PN, et al. Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions. Mol Cell Biol 1984;4:2321–31
- Lee EC, Yu D, Martinez de Velasco J, et al. A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 2001;73:56–65
- Yanai K, Saito T, Kakinuma Y, et al. Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J Biol Chem 2000;275:5–8
- Fukamizu A, Sugimura K, Takimoto E, et al. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J Biol Chem 1993;268:11617–21
- Tanimoto K, Sugiyama F, Goto Y, et al. Angiotensinogen–deficient mice with hypotension. J Biol Chem 1994;269:31334–7
- Lee G, Saito I. Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination. Gene 1998;216:55–65
- Adams DJ, Head GA, Markus MA, et al. Renin enhancer is critical for control of renin gene expression and cardiovascular function. J Biol Chem 2006;281:31753–61
- Markus MA, Goy C, Adams DJ, et al. Renin enhancer is crucial for full response in Renin expression to an in vivo stimulus. Hypertension 2007;50:933–8
- Zhou X, Davis DR, Sigmund CD. The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. J Biol Chem 2006;281:35296–304
- Glenn ST, Jones CA, Pan L, Gross KW. In vivo analysis of key elements within the renin regulatory region. Physiol Genom 2008;35:243–53
- Fuchs S, Philippe J, Germain S, et al. Functionality of two new polymorphisms in the human renin gene enhancer region. J Hypertension 2002;20:2391–8
- Moore N, Dicker P, O'Brien JK, et al. Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition. Hypertension 2007;50:340–7
- Vangjeli C, Clarke N, Quinn U, et al. Confirmation that the renin gene distal enhancer polymorphism REN-5312C/T is associated with increased blood pressure. Circulation Cardiovascular Genetics 2010;3:53–9