Insulin exerts neuroprotective effects via Akt/Bcl-2 signaling pathways in differentiated SH-SY5Y cells

References

• Ramalingam M, Kim SJ. Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases. J Neural Transm 2012;119:891–910
   PubMed Web of Science ®Google Scholar
• Mahesh R, Kim SJ. The protective effects of insulin on hydrogen peroxide-induced oxidative stress in C6 glial cells. Biomol Ther 2009;17:395–402
   Web of Science ®Google Scholar
• Mahesh R, Jung HW, Kim YH, Park YK. Antioxidant and neuroprotective effects of JP05, a polyherbal medicine, on hydrogen peroxide-induced oxidative injury in Neuro-2a neuroblastoma cells. Curr Top Nutraceut R 2011;9:13–23
   Web of Science ®Google Scholar
• Steiner DF, Oyer PE. The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma. Proc Natl Acad Sci USA 1967;57:473–80
   PubMed Web of Science ®Google Scholar
• McLaren DS. Is insulin resistance becoming a global epidemic? Nutrition 1997;13:64–6
   Web of Science ®Google Scholar
• Baura GD, Foster DM, Porte Jr, D, et al. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest 1993;92:1824–30
   PubMed Web of Science ®Google Scholar
• Devaskar SU, Giddings SJ, Rajakumar PA, et al. Insulin gene expression and insulin synthesis in mammalian neuronal cells. J Biol Chem 1994;269:8445–54
   PubMed Web of Science ®Google Scholar
• Ramalingam M, Kim SJ. Mechanisms of action of brain insulin against neurodegenerative diseases. J Neural Transm 2014 (epub ahead of print)
   PubMed Web of Science ®Google Scholar
• Metz HE, Houghton AM. Insulin receptor substrate regulation of phosphoinositide 3-kinase. Clin Cancer Res 2011;17:206–11
   PubMed Web of Science ®Google Scholar
• Holscher C, van Aalten L, Sutherland C. Anaesthesia generates neuronal insulin resistance by inducing hypothermia. BMC Neurosci 2008;9:100
   PubMed Web of Science ®Google Scholar
• Nemoto T, Satoh S, Maruta T, et al. Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3 beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation. Neuropharmacology 2010;58:1097–108
   PubMed Web of Science ®Google Scholar
• Takeda S, Sato N, Rakugi H, Morishita R. Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. Mol Biosyst 2011;7:1822–7
   PubMed Web of Science ®Google Scholar
• Bonneau B, Prudent J, Popgeorgiev N, Gillet G. Non-apoptotic roles of Bcl-2 family: the calcium connection. Biochim Biophys Acta 2013;1833:1755–65
   PubMed Web of Science ®Google Scholar
• Kim SJ, Han Y. Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt). J Neural Transm 2005;112:179–91
   PubMed Web of Science ®Google Scholar
• Ramalingam M, Kim SJ. The role of insulin against hydrogen peroxide-induced oxidative damages in differentiated SH-SY5Y cells. J Recept Signal Transduct Res 2014 (epub ahead of print)
   Web of Science ®Google Scholar
• Ramalingam M, Kim SJ. Insulin on hydrogen peroxide-induced oxidative stress involves ROS/Ca and Akt/Bcl-2 signaling pathways. Free Radic Res 2014;48:347–56
   PubMed Web of Science ®Google Scholar
• Wang W, Sun F, An Y, et al. Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity. Eur J Pharmacol 2009;613:19–23
   PubMed Web of Science ®Google Scholar
• Spiteller G. Are changes of the cell membrane structure causally involved in the aging process? Ann NY Acad Sci 2002;959:30–44
   PubMed Web of Science ®Google Scholar
• Shi C, Zhao L, Zhu B, et al. Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells. Chem Biol Interact 2009;180:389–97
   PubMed Web of Science ®Google Scholar
• Mahesh R, Jung HW, Han CH, et al. Joongpoongtang 05 (JP05) confers neuroprotection via anti-apoptotic activities in Neuro-2a cells during oxygen-glucose deprivation and reperfusion. Toxicol In Vitro 2011;25:177–84
   PubMed Web of Science ®Google Scholar
• Mahesh R, Jung HW, Kim GW, et al. Cryptotanshinone from Salviae miltiorrhizae radix inhibits sodium-nitroprusside-induced apoptosis in Neuro-2a cells. Phytother Res 2012;26:1211–9
   PubMed Web of Science ®Google Scholar
• Moloney AM, Griffin RJ, Timmons S, et al. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 2010;31:224–43
   PubMed Web of Science ®Google Scholar
• Zhao W, Chen H, Xu H, et al. Brain insulin receptors and spatial memory: correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem 1999;274:34893–902
   PubMed Web of Science ®Google Scholar
• Benomar Y, Roy AF, Aubourg A, et al. Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line. Biochem J 2005;388:929–39
   PubMed Web of Science ®Google Scholar
• White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 2002;283:E413–22
   PubMed Web of Science ®Google Scholar
• White MF. Regulating insulin signaling and beta-cell function through IRS proteins. Can J Physiol Pharmacol 2006;84:725–37
   PubMed Web of Science ®Google Scholar
• Saltiel AR, Pessin JE. Insulin signaling pathways in time and space. Trends Cell Biol 2002;12:65–71
   PubMed Web of Science ®Google Scholar
• Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 2012;122:1316–38
   PubMed Web of Science ®Google Scholar
• Hirayama I, Tamemoto H, Yokota H, et al. Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2. Diabetes 1999;48:1237–44
   PubMed Web of Science ®Google Scholar
• Scheid MP, Woodgett JR. PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol 2001;2:760–8
   PubMed Web of Science ®Google Scholar