330
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Spinorphin inhibits membrane depolarization- and capsaicin-induced intracellular calcium signals in rat primary nociceptive dorsal root ganglion neurons in culture

, , &
Pages 550-558 | Received 10 Nov 2014, Accepted 19 Feb 2015, Published online: 08 Jun 2015

References

  • Reynolds DV. Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science 1969;164:444–5
  • Staud R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother 2012;12:577–85
  • Marchand S. The physiology of pain mechanisms: from the periphery to the brain. Rheum Dis Clin N Am 2008;34:285–309
  • Voscopoulos C, Lema M. When does acute pain become chronic? Br J Anaesth 2010;105:79–85
  • Mason P. Deconstructing endogenous pain modulations. J Neurophysiol 2005;94:1659–63
  • Argoff C. Mechanisms of pain transmission and pharmacologic management. Curr Med Res Opin 2011;27:2019–31
  • Thanawala V, Kadam VJ, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets 2008;9:887–94
  • Yamamoto Y, Ono H, Ueda A, et al. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation. Curr Protein Pept Sci 2002;3:587–99
  • Ueda H, Matsunaga S, Inoue M, et al. Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine. Peptides 2000;21:1215–21
  • Honda M, Okutsu H, Matsuura T, et al. Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn J Pharmacol 2001;87:261–67
  • Harper AA, Lawson SN. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurons. J Physiol 1985;359:31–46
  • Lawson SN, Perry MJ, Prabhakar E, McCarthy PW. Primary sensory neurones: neurofilament, neuropeptides, and conduction velocity. Brain Res Bull 1993;30:239–43
  • Costigan M, Scholz J, Samad T, Woolf CJ. Pain. In: Seigel JG, Albers RW, Brandy ST, Price DL, eds. Basic neurochemistry: molecular, cellular, and medical aspects. London: Elsevier; 2006:927–37
  • Kress M, Reeh PW. More sensory competence for nociceptive neurons in culture. Proc Natl Acad Sci USA 1996;93:14995–7
  • Vyklický L, Knotková-Urbancovä H. Can sensory neurones in culture serve as a model of nociception? Physiol Res 1996;45:1–9
  • Catterall WA. Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release. Cell Calcium 1998;24:307–23
  • Bourinet E, Altier C, Hildebrand ME, et al. Calcium-permeable ion channels in pain signaling. Physiol Rev 2014;94:81–140
  • Hagenacker T, Ledwig D, Büsselberg D. Feedback mechanisms in the regulation of intracellular calcium ([Ca2+]i) in the peripheral nociceptive system: role of TRPV-1 and pain related receptors. Cell Calcium 2008;43:215–27
  • Fernyhough P, Calcutt NA. Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium 2010;47:130–9
  • Ozaki Y, Kitamura N, Tsutsumi A, et al. NGF-induced hyperexcitability causes spontaneous fluctuations of intracellular Ca2+ in rat nociceptive dorsal root ganglion neurons. Cell Calcium 2009;45:209–15
  • Ozcan M, Ayar A. Modulation of action potential and calcium signaling by levetiracetam in rat sensory neurons. J Recept Signal Transduct Res 2012;32:156–62
  • Scroggs RS, Fox AP. Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size. J Physiol 1992;445:639–58
  • Loyd DR, Henry MA, Hargreaves KM. Serotonergic neuromodulation of peripheral nociceptors. Semin Cell Dev Biol 2013;24:51–7
  • Dickenson AH, Sullivan AF, Fournié-Zaluski MC, Roques BP. Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurons in rat spinal cord. Brain Res 1987;408:185–91
  • Maldonado R, Valverde O, Turcaud S, et al. Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation. Pain 1994;58:77–83
  • Lu SG, Zhang X, Gold MS. Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons. J Physiol 2006;577:169–90
  • Eun SY, Jung SJ, Park YK, et al. Effects of capsaicin on Ca2+ release from the intracellular Ca2+ stores in the dorsal root ganglion cells of adult rats. Biochem Biophys Res Commun 2001;285:1114–20
  • Jung KY, Moon HD, Lee GE, et al. Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem 2007;50:4543–7
  • Lewis C, Neidhart S, Holy C, et al. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 1995;377:432–5
  • Yamamoto Y, Kanazawa T, Shimamura M, et al. Inhibitory effects of spinorphin, a novel endogenous regulator, on chemotaxis, O2-generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils. Biochem Pharmacol 1997;54:695–701
  • Liang TS, Gao JL, Fatemi O, et al. The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J Immunol 2001;167:6609–14

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.