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Review Article

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

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Pages 600-604 | Received 06 Feb 2015, Accepted 12 Mar 2015, Published online: 22 Jun 2015

References

  • Pan HC, Jiang Q, Yu Y, et al. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells. Neurochem Int 2015;80:60–71
  • Guo G, Yao W, Zhang Q, Bo Y. Oleanolic acid suppresses migration and invasion of malignant glioma cells by inactivating MAPK/ERK signaling pathway. PLoS One 2013;8:e72079
  • Cha JH, Choi YJ, Cha SH, et al. Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncol Rep 2012;28:41–8
  • Tian Y, Guan Y, Jia Y, et al. Chloride intracellular channel 1 regulates prostate cancer cell proliferation and migration through the MAPK/ERK pathway. Cancer Biother Radiopharm 2014;29:339–44
  • Nikhil K, Sharan S, Chakraborty A, Roy P. Pterostilbene–isothiocyanate conjugate suppresses growth of prostate cancer cells irrespective of androgen receptor status. PLoS One 2014;9:e93335
  • Zhan YH, Liu J, Qu XJ, et al. Beta-elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/mTOR signalling pathways. Asian Pac J Cancer Prev 2012;13:2739–44
  • Zheng Y, Wang X, Wang H, et al. Expression of the lysyl oxidase propeptide in hepatocellular carcinoma and its clinical relevance. Oncol Rep 2014;31:1669–76
  • Zhang R, Wang J, Ma S, et al. Requirement of osteopontin in the migration and protection against taxol-induced apoptosis via the ATX-LPA axis in SGC7901 cells. BMC Cell Biol 2011;12:11
  • Xavier CP, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C. Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway. Nutr Cancer 2009;61:564–71
  • Park HK, Kim IH, Kim J, Nam TJ. Induction of apoptosis by laminarin, regulating the insulin-like growth factor-IR signaling pathways in HT-29 human colon cells. Int J Mol Med 2012;30:734–8
  • Qu J, Zhao M, Teng Y, et al. Interferon-alpha sensitizes human gastric cancer cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway. Cancer Biol Ther 2011;12:494–502
  • Kim TI, Jin SH, Kim WH, et al. Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells. Int J Colorectal Dis 2001;16:167–73
  • Sutter AP, Maaser K, Gerst B, et al. Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase. Biochem Pharmacol 2004;67:1701–10
  • Chang YC, Hsu YC, Liu CL, et al. Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. PLoS One 2014;9:e89563
  • Roy SK, Srivastava RK, Shankar S. Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 2010;5:10
  • Das S, Dey KK, Bharti R, et al. PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma. J Exp Ther Oncol 2012;10:139–53
  • Carlo-Stella C, Locatelli SL, Giacomini A, et al. Sorafenib inhibits lymphoma xenografts by targeting MAPK/ERK and AKT pathways in tumor and vascular cells. PLoS One 2013;8:e61603
  • Lee SY, Shin SJ, Kim HS. ERK1/2 activation mediated by the nutlin3induced mitochondrial translocation of p53. Int J Oncol 2013;42:1027–35
  • Gao J, Zhao Y, Lv Y, et al. Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells. Cancer Cell Int 2013;13:2
  • Zhang Y, Song M, Cui ZS, et al. Down-regulation of TSG101 by small interfering RNA inhibits the proliferation of breast cancer cells through the MAPK/ERK signal pathway. Histol Histopathol 2011;26:87–94
  • Watanabe M, Naraba H, Sakyo T, Kitagawa T. DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells. Mol Cancer Res 2010;8:1547–57
  • Sarkar S, Mazumdar A, Dash R, et al. ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer Biol Ther 2010;9:592–603
  • Miao JH, Wang SQ, Zhang MH, et al. Knockdown of galectin-1 suppresses the growth and invasion of osteosarcoma cells through inhibition of the MAPK/ERK pathway. Oncol Rep 2014;32:1497–504
  • Choi CH, Lee BH, Ahn SG, Oh SH. Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3beta. Biochem Biophys Res Commun 2012;418:759–64
  • Chang MC, Chen CA, Chen PJ, et al. Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. Biochem J 2012;442:293–302
  • Noh K, Kim KO, Patel NR, et al. Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas. J Bone Joint Surg Am 2011;93:723–32
  • Wang Z, Luo F, Li L, et al. STAT3 activation induced by Epstein–Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. Eur J Cancer 2010;46:2996–3006
  • Aoudjit F, Guo W, Gagnon-Houde JV, et al. HLA-DR signaling inhibits Fas-mediated apoptosis in A375 melanoma cells. Exp Cell Res 2004;299:79–90
  • Umoh NA, Walker RK, Millis RM, et al. Calcitonin gene-related peptide regulates cardiomyocyte survival through regulation of oxidative stress by PI3K/Akt and MAPK signaling pathways. Ann Clin Exp Hypertens 2014;2:1007
  • Liu Q, Hofmann PA. Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am J Physiol Heart Circ Physiol 2004;286:H2204–12
  • Wang L, Li X, Zhou Y, et al. Downregulation of miR-133 via MAPK/ERK signaling pathway involved in nicotine-induced cardiomyocyte apoptosis. Naunyn Schmiedebergs Arch Pharmacol 2014;387:197–206
  • Li MQ, Shao J, Meng YH, et al. NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Hum Reprod 2013;28:2822–31
  • Sheikh AQ, Taghian T, Hemingway B, et al. Regulation of endothelial MAPK/ERK signalling and capillary morphogenesis by low-amplitude electric field. J R Soc Interface 2013;10:20120548
  • Gupta K, Kshirsagar S, Li W, et al. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 1999;247:495–504
  • Chen J, Aguilera G. Vasopressin protects hippocampal neurones in culture against nutrient deprivation or glutamate-induced apoptosis. J Neuroendocrinol 2010;22:1072–81
  • Zou X, Gao J, Zheng Y, et al. Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death. Cell Death Dis 2014;5:e1218
  • Hossain MS, Ifuku M, Take S, et al. Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling. PLoS One 2013;8:e83508
  • Hu S, Cui W, Mak S, et al. Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3beta pathways. Neurochem Int 2013;62:468–77
  • Kim SW, Lim CM, Kim JB, et al. Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway. Neurotox Res 2011;20:159–69
  • Lim JY, Park SI, Oh JH, et al. Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways. J Neurosci Res 2008;86:2168–78
  • Lallemend F, Lefebvre PP, Hans G, et al. Substance P protects spiral ganglion neurons from apoptosis via PKC-Ca2+-MAPK/ERK pathways. J Neurochem 2003;87:508–21
  • Anderson CN, Tolkovsky AM. A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside. J Neurosci 1999;19:664–73
  • Marques-Fernandez F, Planells-Ferrer L, Gozzelino R, et al. TNFalpha induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway. Cell Death Dis 2013;4:e493
  • Fang XX, Jiang XL, Han XH, et al. Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3, MAPK/ERK, and PI3K/AKT signaling pathways. Cell Mol Neurobiol 2013;33:241–51
  • Gupta VK, You Y, Li JC, et al. Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. J Mol Neurosci 2013;49:96–104
  • Zhao Y, Luo P, Guo Q, et al. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo. Exp Neurol 2012;237:489–98
  • Bravo-San Pedro JM, Niso-Santano M, Gomez-Sanchez R, et al. The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway. Cell Mol Life Sci 2013;70:121–36
  • Ozcan Z, Gul G, Yaman I. Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1–2 pathways in human proximal tubule HK-2 cells. Arch Toxicol DOI: 10.1007/s00204-014-1311-x
  • Zhang X, Liang D, Guo B, et al. Zinc inhibits high glucose-induced apoptosis in peritoneal mesothelial cells. Biol Trace Elem Res 2012;150:424–32
  • Xu T, Wang NS, Fu LL, et al. Celecoxib inhibits growth of human autosomal dominant polycystic kidney cyst-lining epithelial cells through the VEGF/Raf/MAPK/ERK signaling pathway. Mol Biol Rep 2012;39:7743–53
  • Yoshikawa M, Hishikawa K, Idei M, Fujita T. Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. Eur J Pharmacol 2010;642:28–36
  • Wan-Xin T, Tian-Lei C, Ben W, et al. Effect of mitofusin 2 overexpression on the proliferation and apoptosis of high-glucose-induced rat glomerular mesangial cells. J Nephrol 2012;25:1023–30
  • Jo SK, Cho WY, Sung SA, et al. MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis. Kidney Int 2005;67:458–66
  • Romero-Ramirez H, Morales-Guadarrama MT, Pelayo R, et al. CD38 expression in early B cell precursors contributes to ERK-mediated apoptosis. Immunology 2014
  • Soderstrom TS, Poukkula M, Holmstrom TH, et al. Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8. J Immunol 2002;169:2851–60
  • Holmstrom TH, Schmitz I, Soderstrom TS, et al. MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. EMBO J 2000;19:5418–28
  • Yu Y, Shiou SR, Guo Y, et al. Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis. PLoS One 2013;8:e69620
  • Tseng HL, Li CJ, Huang LH, et al. Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway. Toxicol Appl Pharmacol 2012;264:104–13
  • Li Q, Huai L, Zhang C, et al. Icaritin induces AML cell apoptosis via the MAPK/ERK and PI3K/AKT signal pathways. Int J Hematol 2013;97:617–23
  • Cosenza M, Civallero M, Grisendi G, et al. Combination of low doses of enzastaurin and lenalidomide has synergistic activity in B-non-Hodgkin lymphoma cell lines. Ann Hematol 2012;91:1613–22
  • Naci D, El Azreq MA, Chetoui N, et al. alpha2beta1 integrin promotes chemoresistance against doxorubicin in cancer cells through extracellular signal-regulated kinase (ERK). J Biol Chem 2012;287:17065–76
  • Herishanu Y, Gibellini F, Njuguna N, et al. Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1. Leuk Lymphoma 2011;52:1758–69
  • Smal C, Lisart S, Ferrant A, et al. Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2′-deoxyadenosine in the B-cell leukemia cell line EHEB. Nucleosides Nucleotides Nucleic Acids 2006;25:1009–12
  • Kandilci A, Grosveld GC. SET-induced calcium signaling and MAPK/ERK pathway activation mediate dendritic cell-like differentiation of U937 cells. Leukemia 2005;19:1439–45
  • Gendron S, Couture J, Aoudjit F. Integrin alpha2beta1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway. J Biol Chem 2003;278:48633–43
  • Xu S, Yang Y, Han S, Wu Z. ZIP1 and zinc inhibits fluoride-induced apoptosis in MC3T3-E1 cells. Biol Trace Elem Res 2014;159:399–409
  • Scuderi S, D'Amico AG, Castorina A, et al. Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death. J Mol Neurosci 2014;54:395–404
  • Kun D, Xiang-Lin C, Ming Z, Qi L. Chlamydia inhibit host cell apoptosis by inducing Bag-1 via the MAPK/ERK survival pathway. Apoptosis 2013;18:1083–92
  • Liang D, Xiang L, Yang M, et al. ZnT7 can protect MC3T3-E1 cells from oxidative stress-induced apoptosis via PI3K/Akt and MAPK/ERK signaling pathways. Cell Signal 2013;25:1126–35
  • Zhu X, Jiang Y, Shan PF, et al. Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway. Amino Acids 2013;44:961–8
  • Li J, Liu S, Li W, et al. Vascular smooth muscle cell apoptosis promotes transplant arteriosclerosis through inducing the production of SDF-1alpha. Am J Transplant 2012;12:2029–43
  • Chera S, Ghila L, Wenger Y, Galliot B. Injury-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration. Dev Growth Differ 2011;53:186–201
  • Karube H, Nishitai G, Inageda K, et al. NaF activates MAPKs and induces apoptosis in odontoblast-like cells. J Dent Res 2009;88:461–5
  • Kornasio R, Riederer I, Butler-Browne G, et al. Beta-hydroxy-beta-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways. Biochim Biophys Acta 2009;1793:755–63
  • Du MR, Zhou WH, Yan FT, et al. Cyclosporine A induces titin expression via MAPK/ERK signalling and improves proliferative and invasive potential of human trophoblast cells. Hum Reprod 2007;22:2528–37
  • Sanna B, Debidda M, Pintus G, et al. The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway. Arch Biochem Biophys 2002;403:209–18
  • Pavlovic D, Andersen NA, Mandrup-Poulsen T, Eizirik DL. Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells. Eur Cytokine Netw 2000;11:267–74

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