References
- Armbruster BN, Li X, Pausch MH, et al. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl Acad Sci USA 2007;104:5163–8
- Urban DJ, Roth BL. DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): chemogenetic tools with therapeutic utility. Ann Rev Pharmacol Toxixol 2015;55:399–417
- Sternson SM, Roth BL. Chemogenetic tools to interrogate brain functions. Ann Rev Neurosci 2014;37:387–407
- Conklin BR, Hsiao EC, Claeysen S, et al. Engineering GPCR signaling pathways with RASSLs. Nature Meth 2008;5:673–8
- Deng W, Goldys EM, Farnham MM, Pilowsky PM. Optogenetics, the intersection between physics and neuroscience: light stimulation of neurons in physiological conditions. Am J Physiol Reg Integ Compar Physiol 2014;307:R1292–302
- Airan RD, Thompson KR, Fenno LE, et al. Temporally precise in vivo control of intracellular signalling. Nature 2009;458:1025–9
- Al-Hasani R, McCall JG, Foshage AM, Bruchas MR. Locus coeruleus κ-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism. Neuropsychopharmacol 2013;38:2484–97
- McCall JG, Kim TI, Shin G, et al. Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics. Nature Prot 2013;8:2413–28
- Kim TI, McCall JG, Jung YH, et al. Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science 2013;340:211–16
- Masseck OA, Rubelowski JM, Spoida K, Herlitze S. Light- and drug-activated G-protein-coupled receptors to control intracellular signalling. Exp Physiol 2011;96:51–6
- Spoida K, Masseck OA, Deneris ES, Herlitze S. Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice. Proc Natl Acad Sci USA 2014;111:6479–84
- Carr 3rd R, Du Y, Quoyer J, et al. Development and characterization of pepducins as Gs-biased allosteric agonists. J Biol Chem 2014;289:35668–84
- Koole C, Wootten D, Simms J, et al. Differential impact of amino Acid substitutions on critical residues of the human glucagon-like Peptide-1 receptor involved in peptide activity and small-molecule allostery. J Pharmacol Exp Ther 2015;353:52–63
- Redka DS, Morizumi T, Elmslie G, et al. Coupling of G proteins to reconstituted monomers and tetramers of the M2 muscarinic receptor. J Biol Chem 2014;289:24347–65
- Pisterzi LF, Jansma DB, Georgiou J, et al. Oligomeric size of the M2 muscarinic receptor in live cells as determined by quantitative fluorescence resonance energy transfer. J Biol Chem 2010;285:16723–38
- Roy SJ, Glazkova I, Frechette L, et al. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Mol Endocrinol 2013;27:1245–66
- Zvonok N, Xu W, Williams J, et al. Mass spectrometry-based GPCR proteomics: comprehensive characterization of the human cannabinoid 1 receptor. J Proteome Res 2010;9:1746–53
- Maudsley S, Siddiqui S, Martin B. Systems analysis of arrestin pathway functions. Prog Mol Biol Translation Sci 2013;118:431–67
- Kahsai AW, Xiao K, Rajagopal S, et al. Multiple ligand-specific conformations of the β2-adrenergic receptor. Nat Chem Biol 2011;7:692–700
- Kahsai AW, Rajagopal S, Sun J, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. Nat Protoc 2014;9:1301–19
- Dore AS, Okrasa K, Patel JC, et al. Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature 2014;511:557–62
- Bortolato A, Dore AS, Hollenstein K, et al. Structure of Class B GPCRs: new horizons for drug discovery. Br J Pharmacol 2014;171:3132–45
- Irannejad R, Tomshine JC, Tomshine JR, et al. Conformational biosensors reveal GPCR signalling from endosomes. Nature 2013;495:534–8
- Tsvetanova NG, von Zastrow M. Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat Chem Biol 2014;10:1061–5
- Tsvetanova NG, Irannejad R, von Zastrow M. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem 2015;290:6689–96
- Mittal N, Roberts K, Pal K, et al. Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway. Cell Rep 2013;5:1010–21
- Rosciglione S, Theriault C, Boily MO, et al. Gαs regulates the post-endocytic sorting of G protein-coupled receptors. Nat Commun 2014;5:4556
- Hamoud N, Tran V, Croteau LP, et al. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. Proc Natl Acad Sci USA 2014;111:3745–50
- Tutunea-Fatan E, Caetano FA, Gros R, Ferguson SS. GRK2 Targeted knock-down results in spontaneous hypertension, and altered vascular GPCR signaling. J Biol Chem 2015;290:5141–55
- Dayer AG, Jacobshagen M, Chaumont-Dubel S, Marin P. 5-HT receptor: a new player controlling the development of neural circuits. ACS Chem Neurosci 2015;6:951–60
- Jacobshagen M, Niquille M, Chaumont-Dubel S, et al. The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. Development 2014;141:3370–7
- Nordstrom KJ, Lagerstrom MC, Waller LM, et al. The secretin GPCRs descended from the family of adhesion GPCRs. Mol Biol Evol 2009;26:71–84
- Ackerman SD, Garcia C, Piao X, et al. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA. Nat Commun 2015;6:6122
- Petersen SC, Luo R, Liebscher I, et al. The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron 2015;85:755–69
- Stoveken HM, Hajduczok AG, Xu L, Tall GG. Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist. Proc Natl Acad Sci USA 2015;112:6194–9
- O'Hayre M, Degese MS, Gutkind JS. Novel insights into G protein and G protein-coupled receptor signaling in cancer. Curr Opin Cell Biol 2014;27:126–35
- O'Hayre M, Vazquez-Prado J, Kufareva I, et al. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer 2013;13:412–24
- Vaque JP, Dorsam RT, Feng X, et al. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell 2013;49:94–108
- Vischer HF, Siderius M, Leurs R, Smit MJ. Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases? Nat Rev Drug Discov 2014;13:123–39