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Review Article

G protein-coupled receptors: potential therapeutic targets for diabetic nephropathy

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Pages 411-421 | Received 21 Jul 2015, Accepted 07 Nov 2015, Published online: 16 Dec 2015

References

  • Tang SC. Diabetic nephropathy: a global and growing threat. Hong Kong Med J 2010;16:244–5
  • Jefferson JA, Shankland SJ, Pichler RH. Proteinuria in diabetic kidney disease: a mechanistic viewpoint. Kidney Int 2008;74:22–36
  • Furukawa M, Gohda T, Tanimoto M, et al. Pathogenesis and novel treatment from the mouse model of type 2 diabetic nephropathy. ScientificWorldJ 2013;2013:928197
  • Wang FL, Tang LQ, Wei W. The connection between GRKs and various signaling pathways involved in diabetic nephropathy. Mol Biol Rep 2012;77:17–26
  • Jia Z, Sun Y, Liu S, et al. COX-2 but not mPGES-1 contributes to renal PGE2 induction and diabetic proteinuria in mice with type-1 diabetes. PLoS One 2014;9:e93182
  • Tang LQ, Liu S, Zhang ST, et al. Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy. Mol Biol Rep 2014;41:3339–47
  • Wu D, Peng F, Zhang B, et al. PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells. J Am Soc Nephrol 2009;20:554–66
  • Tominaga T, Abe H, Ueda O, et al. Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy. J Biol Chem 2011;286:20109–16
  • Thibodeau JF, Nasrallah R, Carter A, et al. PTGER1 deletion attenuates renal injury in diabetic mouse models. Am J Pathol 2013;183:1789–802
  • Makino H, Tanaka I, Mukoyama M, et al. Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist. J Am Soc Nephrol 2002;1:1757–65
  • Yang T, Du Y. Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation. Am J Hypertens 2012;25:1042–9
  • Mohamed R, Jayakumar C, Ramesh G. Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6. Lab Invest 2013;93:933–45
  • Stitt-Cavanagh EM, Faour WH, Takami K, et al. A maladaptive role for EP4 receptors in podocytes. J Am Soc Nephrol 2010;21:1678–90
  • Yang Y, Ni W, Cai M, et al. The renoprotective effects of berberine via the EP4-Gαs-cAMP signaling pathway in different stages of diabetes in rats. J Recept Signal Transduct Res 2014;34:445–55
  • Elsherbiny NM, Al-Gayyar MM. Adenosine receptors: new therapeutic targets for inflammation in diabetic nephropathy. Inflamm Allergy Drug Targets 2013;12:153–61
  • Quezada C, Alarcon S, Jaramillo C, et al. Targeting adenosine signaling to treatment of diabetic nephropathy. Curr Drug Targets 2013;14:490–6
  • Eisenstein A, Ravid K. G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. J Cell Physiol 2014;229:414–21
  • Cardenas A, Toledo C, Oyarzun C, et al. Adenosine A(2B) receptor-mediated VEGF induction promotes diabetic glomerulopathy. Lab Invest 2013;93:135–44
  • Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003;111:707–16
  • Sison K, Eremina V, Baelde H, et al. Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol 2010;21:1691–701
  • Schrijvers BF, De Vriese AS, Tilton RG, et al. Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes. Horm Metab Res 2005;37:21–5
  • Lan HY, Chung AC. TGF-beta/Smad signaling in kidney disease. Semin Nephrol 2012;32:236–43
  • Ibrahim AS, El-Shishtawy MM, Zhang W, et al. A((2)A) adenosine receptor (A((2)A)AR) as a therapeutic target in diabetic retinopathy. Am J Pathol 2011;178:2136–45
  • Awad AS, Rouse M, Liu L, et al. Activation of adenosine 2A receptors preserves structure and function of podocytes. J Am Soc Nephrol 2008;19:59–68
  • Vallon V, Schroth J, Satriano J, et al. Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus. Nephron Physiol 2009;111:30–8
  • Kohan DE. Endothelin, hypertension and chronic kidney disease: new insights. Curr Opin Nephrol Hypertens 2010;19:134–9
  • Lenoir O, Milon M, Virsolvy A, et al. Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. J Am Soc Nephrol 2014;25:1050–62
  • Horinouchi T, Terada K, Higashi T, Miwa S. Endothelin receptor signaling: new insight into its regulatory mechanisms. J Pharmacol Sci 2013;123:85–101
  • Yang J, Zeng Z, Wu T, et al. Emodin attenuates high glucose-induced TGF-β1 and fibronectin expression in mesangial cells through inhibition of NF-κB pathway. Exp Cell Res 2013;319:3182–9
  • Miura S, Imaizumi S, Saku K. Recent progress in molecular mechanisms of angiotensin II type 1 and 2 receptors. Curr Pharm Des 2013;19:2981–7
  • Zoja C, Cattaneo S, Fiordaliso F, et al. Distinct cardiac and renal effects of ETA receptor antagonist and ACE inhibitor in experimental type 2 diabetes. Am J Physiol Renal Physiol 2011;301:F1114–23
  • Sen S, Chen S, Feng B, et al. Renal, retinal and cardiac changes in type 2 diabetes are attenuated by macitentan, a dual endothelin receptor antagonist. Life Sci 2012;91:658–68
  • Oates PJ. Aldose reductase inhibitors and diabetic kidney disease. Curr Opin Investig Drugs 2010;11:402–17
  • Pfab T, Thone-Reineke C, Theilig F, et al. Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure. J Am Soc Nephrol 2006;17:1082–9
  • Ketsawatsomkron P, Stepp DW, Fulton DJ, Marrero MB. Molecular mechanism of angiotensin II-induced insulin resistance in aortic vascular smooth muscle cells: roles of protein tyrosine phosphatase-1B. Vascul Pharmacol 2010;53:160–8
  • Akazawa H, Yano M, Yabumoto C, et al. Angiotensin II type 1 and type 2 receptor-induced cell signaling. Curr Pharm Des 2013;19:2988–95
  • Ni WJ, Tang LQ, Wei W. Research progress in signalling pathway in diabetic nephropathy. Diabetes Metab Res Rev 2015;31:221–33
  • Muller-Fielitz H, Landolt J, Heidbreder M, et al. Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARγ target gene regulation. Endocrinology 2012;153:1103–15
  • Thangaraju P, Chakrabarti A, Banerjee D, et al. Dual blockade of renin angiotensin system in reducing the early changes of diabetic retinopathy and nephropathy in a diabetic rat model. N Am J Med Sci 2014;6:625–32
  • Mima A, Kitada M, Geraldes P, et al. Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy. FASEB J 2012;26:2963–74
  • Koulis C, Chow BS, McKelvey M, et al. AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy. Hypertension 2015;65:1073–81
  • Jenkin KA, Verty AN, McAinch AJ, et al. Endocannabinoids and the renal proximal tubule: an emerging role in diabetic nephropathy. Int J Biochem Cell Biol 2012;44:2028–31
  • Nam DH, Lee MH, Kim JE, et al. Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice. Endocrinology 2012;153:1387–96
  • Lim SK, Park SH. The high glucose-induced stimulation of B1R and B2R expression via CB(1)R activation is involved in rat podocyte apoptosis. Life Sci 2012;91:895–906
  • Barutta F, Corbelli A, Mastrocola R, et al. Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy. Diabetes 2010;59:1046–54
  • Barutta F, Grimaldi S, Franco I, et al. Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice. Kidney Int 2014;86:979–90
  • Barutta F, Piscitelli F, Pinach S, et al. Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy. Diabetes 2011;60:2386–96
  • Puddu A, Mach F, Nencioni A, et al. An emerging role of glucagon-like peptide-1 in preventing advanced-glycation-end-product-mediated damages in diabetes. Mediators Inflamm 2013;2013:591056
  • Li W, Cui M, Wei Y, et al. Inhibition of the expression of TGF-β1 and CTGF in human mesangial cells by exendin-4, a glucagon-like peptide-1 receptor agonist. Cell Physiol Biochem 2012;30:749–57
  • Xie J, El SN, Qi C, et al. Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1. J Mol Endocrinol 2014;53:105–15
  • Mima A, Hiraoka-Yamomoto J, Li Q, et al. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes. Diabetes 2012;61:2967–79
  • Kodera R, Shikata K, Kataoka HU, et al. Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Diabetologia 2011;54:965–78
  • Imasawa T, Kitamura H, Ohkawa R, et al. Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy. Exp Toxicol Pathol 2010;62:53–60
  • Nam BY, Paeng J, Kim SH, et al. The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions. Apoptosis 2012;17:1–13
  • Day RT, Cavaglieri RC, Feliers D. Apelin retards the progression of diabetic nephropathy. Am J Physiol Renal Physiol 2013;304:F788–800

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