5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone, a polymethoxyflavone, exerts antitumor effect on PI3K/Akt signaling pathway in human gastric cancer cell BGC-7901

References

• Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013;63:11–30
   PubMed Web of Science ®Google Scholar
• Xie X, Tang B, Zhou J, et al. Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine. Oncol Rep 2013;30:773–82
   PubMed Web of Science ®Google Scholar
• Duan L, Ye LW, Wu R, et al. Inactivation of the phosphatidylinositol 3-kinase/Akt pathway is involved in BMP9-mediated tumor-suppressive effects in gastric cancer cells. J Cell Biochem 2015;116:1080–9
   PubMed Web of Science ®Google Scholar
• Yasui W, Oue N, Aung PP, et al. Molecular-pathological prognostic factors of gastric cancer: a review. Gastric Cancer 2005;8:86–94
   PubMedGoogle Scholar
• Janku F, Wheler JJ, Westin SN, et al. PI3K/Akt/mtor inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 2012;30:777–82
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang X, Sun Y, et al. LYG-202 exerts antitumor effect on PI3K/Akt signaling pathway in human breast cancer cells. Apoptosis 2015;20:1253–69
   PubMed Web of Science ®Google Scholar
• Cheung M, Testa JR. Diverse mechanisms of Akt pathway activation in human malignancy. Curr Cancer Drug Targets 2013;13:234–44
   PubMed Web of Science ®Google Scholar
• Tian F, Ding D, Li DD. Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells. Int J Oncol 2015;46:2355–63
   PubMed Web of Science ®Google Scholar
• Ashour AA, Abdel-Aziz AA, Mansour AM, et al. Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. Apoptosis 2014;19:241–58
   PubMed Web of Science ®Google Scholar
• Pan MH, Chen WJ, Lin-Shiau SY, et al. Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis 2002;23:1677–84
   PubMed Web of Science ®Google Scholar
• Li S, Lo CY, Ho CT. Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. J Agric Food Chem 2006;54:4176–85
   PubMed Web of Science ®Google Scholar
• Li S, Wang Z, Sang S, et al. Identification of nobiletin metabolites in mouse urine. Mol Nutr Food Res 2006;50:291–9
   PubMed Web of Science ®Google Scholar
• Middleton E, Jr Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673–751
   PubMed Web of Science ®Google Scholar
• Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem 2001;8:135–53
   PubMed Web of Science ®Google Scholar
• Qiu P, Guan H, Dong P, et al. The inhibitory effects of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone on human colon cancer cells. Mol Nutr Food Res 2011;55:1523–32
   PubMed Web of Science ®Google Scholar
• Pan MH, Lai YS, Lai CS, et al. 5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells. J Agric Food Chem 2007;55:5081–91
   PubMed Web of Science ®Google Scholar
• Sergeev IN, Li S, Colby J, et al. Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells. Life Sci 2006;80:245–53
   PubMed Web of Science ®Google Scholar
• Tan S, Sagara Y, Liu Y, et al. The regulation of reactive oxygen species production during programmed cell death. J Cell Biol 1998;141:1423–32
   PubMed Web of Science ®Google Scholar
• Wang TE, Wang YK, Jin J, et al. A novel derivative of quinazoline, WYK431 induces G2/M phase arrest and apoptosis in human gastric cancer BGC823 cells through the PI3K/Akt pathway. Int J Oncol 2014;45:771–81
   PubMed Web of Science ®Google Scholar
• Gustafsson AB, Gottlieb RA. Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol 2007;292:C45–51
   PubMed Web of Science ®Google Scholar
• Kumar S. Caspase function in programmed cell death. Cell Death Differ 2007;14:32–43
   PubMed Web of Science ®Google Scholar
• Yun J, Lv YG, Yao Q, et al. Wortmannin inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells. Eur J Gynaecol Oncol 2012;33:367–9
   PubMed Web of Science ®Google Scholar
• Qiu PJ, Dong P, Guan HS, et al. Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. Mol Nutr Food Res 2010;54:S244–52
   Google Scholar
• Su CC, Chen JY, Din ZH, et al. 13-Acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression. Mar Drugs 2014;12:5295–315
   PubMed Web of Science ®Google Scholar
• Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 2011;21:92–101
   PubMed Web of Science ®Google Scholar
• Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309–12
   PubMed Web of Science ®Google Scholar
• Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science 2003;299:214–15
   PubMed Web of Science ®Google Scholar
• Ferreira CG, Epping M, Kruyt FA, Giaccone G. Apoptosis: target of cancer therapy. Clin Cancer Res 2002;8:2024–34
   PubMed Web of Science ®Google Scholar
• Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998;281:1322–6
   PubMed Web of Science ®Google Scholar
• Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000;5:415–18
   PubMed Web of Science ®Google Scholar
• Zamzami N, Marchetti P, Castedo M, et al. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 1995;182:367–77
   PubMed Web of Science ®Google Scholar
• Ma Q, Fang H, Shang W, et al. Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis. J Biol Chem 2011;286:27573–81
   PubMed Web of Science ®Google Scholar
• Park J, Ko YS, Yoon J, et al. The forkhead transcription factor FOXO1 mediates cisplatin resistance in gastric cancer cells by activating phosphoinositide 3-kinase/Akt pathway. Gastric Cancer 2014;17:423–30
   PubMed Web of Science ®Google Scholar
• Cheng HB, Bo Y, Shen WX, et al. Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS. Naunyn Schmiedebergs Arch Pharmacol 2015;388:623–34
   PubMed Web of Science ®Google Scholar
• Lee JH, Won YS, Park KH, et al. Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling. Apoptosis 2012;17:1275–86
   PubMed Web of Science ®Google Scholar