Potent inhibition of angiotensin AT₁ receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain

References

• Maguire JJ, Davenport AP. Regulation of vascular reactivity by established and emerging GPCRs. Trends Pharmacol Sci 2005;26:448–54.
   PubMed Web of Science ®Google Scholar
• Salazar NC, Chen J, Rockman HA. Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta 2007;1768:1006–18.
   PubMed Web of Science ®Google Scholar
• Gu S, Cifelli C, Wang S, et al. RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function. Clin Sci (Lond) 2009;116:391–9.
   PubMed Web of Science ®Google Scholar
• Willars GB. Mammalian RGS proteins: multifunctional regulators of cellular signalling. Semin Cell Dev Biol 2006;17:363–76.
   PubMed Web of Science ®Google Scholar
• Bansal G, Druey KM, Xie Z. R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther 2007;116:473–95.
   PubMed Web of Science ®Google Scholar
• Hendriks-Balk MC, Peters SL, Michel MC, et al. Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins. Eur J Pharmacol 2008;585:278–91.
   PubMed Web of Science ®Google Scholar
• Gu S, He J, Ho WT, et al. Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. J Biol Chem 2007;282:33064–75.
   PubMed Web of Science ®Google Scholar
• Heximer SP, Knutsen RH, Sun X, et al. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 2003;111:445–52.
   PubMed Web of Science ®Google Scholar
• Cifelli C, Rose RA, Zhang H, et al. RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res 2008;103:527–35.
   PubMed Web of Science ®Google Scholar
• Cho H, Park C, Hwang IY, et al. Rgs5 targeting leads to chronic low blood pressure and a lean body habitus. Mol Cell Biol 2008;28:2590–7.
   PubMed Web of Science ®Google Scholar
• Matsuzaki N, Nishiyama M, Song D, et al. Potent and selective inhibition of angiotensin AT1 receptor signaling by RGS2: roles of its N-terminal domain. Cell Signal 2011;23:1041–9.
   PubMed Web of Science ®Google Scholar
• Ishida J, Asada S, Daitoku H, et al. Expression and characterization of mouse angiotensin II type 1a receptor tagging hemagglutinin epitope in cultured cells. Int J Mol Med 1999;3:263–70.
   PubMed Web of Science ®Google Scholar
• Soundararajan M, Willard FS, Kimple AJ, et al. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci USA 2008;105:6457–62.
   PubMed Web of Science ®Google Scholar
• Karakoula A, Tovey SC, Brighton PJ, et al. Lack of receptor-selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone receptor-mediated signalling through G alpha q/11. Eur J Pharmacol 2008;587:16–24.
   PubMed Web of Science ®Google Scholar
• Kardestuncer T, Wu H, Lim AL, et al. Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria. FEBS Lett 1998;438:285–8.
   PubMed Web of Science ®Google Scholar
• Doupnik CA, Xu T, Shinaman JM. Profile of RGS expression in single rat atrial myocytes. Biochim Biophys Acta 2001;1522:97–107.
   PubMed Web of Science ®Google Scholar
• Mittmann C, Chung CH, Höppner G, et al. Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure. Cardiovasc Res 2002;55:778–86.
   PubMed Web of Science ®Google Scholar
• Saitoh O, Kubo Y, Miyatani Y, et al. RGS8 accelerates G-protein-mediated modulation of K+ currents. Nature 1997;390:525–9.
   PubMed Web of Science ®Google Scholar
• Saitoh O, Masuho I, Terakawa I, et al. Regulator of G protein signaling 8 (RGS8) requires its NH2 terminus for subcellular localization and acute desensitization of G protein-gated K+ channels. J Biol Chem 2001;276:5052–8.
   PubMed Web of Science ®Google Scholar
• Saavedra JM. Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities. Cell Mol Neurobiol 2005;25:485–512.
   PubMed Web of Science ®Google Scholar
• Kuwata H, Nakao K, Harada T, et al. Generation of RGS8 null mutant mice by Cre/loxP system. Kobe J Med Sci 2008;53:275–81.
   PubMedGoogle Scholar
• Chatterjee TK, Eapen AK, Fisher RA. A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C. J Biol Chem 1997;272:15481–7.
   PubMed Web of Science ®Google Scholar
• Shi CS, Lee SB, Sinnarajah S, et al. Regulator of G-protein signaling 3 (RGS3) inhibits Gβ1γ2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. J Biol Chem 2001;276:24293–300.
   PubMed Web of Science ®Google Scholar
• Gō M. Correlation of DNA exonic regions with protein structural units in haemoglobin. Nature 1981;291:90–2.
   PubMed Web of Science ®Google Scholar
• Go M. Modular structural units, exons, and function in chicken lysozyme. Proc Natl Acad Sci USA 1983;80:1964–8.
   PubMed Web of Science ®Google Scholar
• Kimple AJ, Bosch DE, Giguère PM, et al. Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev 2011;63:728–49.
   PubMed Web of Science ®Google Scholar
• Tesmer JJ, Berman DM, Gilman AG, et al. Structure of RGS4 bound to -activated Giα1: stabilization of the transition state for GTP hydrolysis. Cell 1997;89:251–61.
   PubMed Web of Science ®Google Scholar
• Srinivasa SP, Watson N, Overton MC, et al. Mechanism of RGS4, a GTPase-activating protein for G protein alpha subunits. J Biol Chem 1998;273:1529–33.
   PubMed Web of Science ®Google Scholar
• Moroi K, Nishiyama M, Kawabata S, et al. Phosphorylation of Ser166 in RGS5 by protein kinase C causes loss of RGS function. Life Sci 2007;81:40–50.
   PubMed Web of Science ®Google Scholar
• Wieland T, Bahtijari N, Zhou XB, et al. Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits. J Biol Chem 2000;275:28500–6.
   PubMed Web of Science ®Google Scholar
• Zhao P, Chidiac P. Regulation of RGS5 GAP activity by GPSM3. Mol Cell Biochem 2015;405:33–40.
   PubMed Web of Science ®Google Scholar
• Sjögren B, Blazer LL, Neubig RR. Regulators of G protein signaling proteins as targets for drug discovery. Prog Mol Biol Transl Sci 2010;91:81–119.
   PubMed Web of Science ®Google Scholar