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Research Article

Allicin relaxes isolated mesenteric arteries through activation of PKA-KATP channel in rat

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Pages 17-24 | Received 07 Oct 2015, Accepted 09 Feb 2016, Published online: 06 Apr 2016

References

  • Schäfer G, Kaschula CH. The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. Anticancer Agents Med Chem 2014;14:233–40
  • Dorant E, van den Brandt PA, Goldbohm RA, et al. Garlic and its significance for the prevention of cancer in humans: a critical view. Br J Cancer 1993;67:424–9
  • Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutr J 2002;1:4
  • Cavallito CJ, Bailey JH. Allicin, the antibacterial principle of Allium sativum. I. Isolation, physical properties and antibacterial action. J Am Chem Soc 1944;66:1950–1
  • Li C, Lun W, Zhao X, et al. Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. Mediators Inflamm 2015;2015:434692
  • Xu L, Yu J, Zhai D, et al. Role of JNK activation and mitochondrial Bax translocation in allicin-induced apoptosis in human ovarian cancer SKOV3 Cells. Evid Based Complement Alternat Med. 2014;2014:378684
  • Tao M, Gao L, Pan J, Wang X. Study on the inhibitory effect of allicin on human gastric cancer cell line SGC-7901 and its mechanism. Afr J Tradit Complement Altern Med 2014;11:176–9
  • Azadi HG, Ghaffari SM, Riazi GH, et al. Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Cytotechnology 2008;56:179–85
  • Elkayam A, Peleg E, Grossman E, et al. Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats. Isr Med Assoc J 2013;15:170–3
  • Li W, Wang D, Song G, et al. The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats. Lipids Health Dis 2010;9:131
  • Kang KT. Endothelium-derived relaxing factors of small resistance arteries in hypertension. Toxicol Res 2014;30:141–8
  • Billaud M, Lohman AW, Johnstone SR, et al. Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev 2014;66:513–69
  • Shi Y, Wu Z, Cui N, et al. PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol 2007;293:R1205–14
  • Shi WW, Yang Y, Shi Y, Jiang C. K(ATP) channel action in vascular tone regulation: from genetics to diseases. Sheng Li Xue Bao 2012;64:1–13
  • Yang ZW, Li DJ, Liu C, et al. Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats. Acta Pharmacol Sin 2011;32:194–200
  • Li L, Wu J, Jiang C. Differential expression of Kir6.1 and SUR2B mRNAs in the vasculature of various tissues in rats. J Membr Biol 2003;196:61
  • Morrissey A, Rosner E, Lanning J, et al. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. BMC Physiol 2005;5:1
  • Orie NN, Thomas AM, Perrino BA, et al. Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway. Br J Pharmacol 2009;157:554–64
  • Purves GI, Kamishima T, Davies LM, et al. Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. J. Physiol. (Lond.) 2009;587:3639–50
  • Ye H, Bi HR, Lü CL, et al. 15-hydroxyeicosatetraenoic acid depressed endothelial nitric oxide synthase activity in pulmonary artery. Sheng Li Xue Bao 2005;57:612–18
  • Li Y, Li Q, Wang Z, et al. 15-HETE suppresses K(+) channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells. Apoptosis 2009;14:42–51
  • Ma C, Li Y, Ma J, et al. Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension. Hypertension 2011;58:679–88
  • Wang Y, Yu L, Cui N, et al. Differential sensitivities of the vascular K(ATP) channel to various PPAR activators. Biochem Pharmacol 2013;85:1495–503
  • Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed 2014;4:1–14
  • Kajimura M, Fukuda R, Bateman RM, et al. Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology. Antioxid Redox Signal 2010;13:157–92
  • Ku DD, Abdel-Razek TT, Dai J, et al. Garlic and its active metabolite allicin produce endothelium and nitric oxide-dependent relaxation in rat pulmonary arteries. Clin Exp Pharmacol Physiol 2002;29:84–91
  • Dumont E, Lamontagne D. No role of ATP-sensitive potassium channels in the vasoconstriction produced by vasopressin. J Vasc Res 1995;32:138--42
  • Yamada M, Isomoto S, Matsumoto S, et al. Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea sensitive but ATP insensitive Kt channel. J Physiol 1997;499:715e20
  • Satoh E, Yamada M, Kondo C, et al. Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modulation by pinacidil. J Physiol 1998;511:663e74
  • Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev 1997;77:1165--232

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