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Research Article

Fluorescence Visualization of Receptor-Bound Low Density Lipoprotein in Human Fibroblasts

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Pages 17-39 | Published online: 26 Sep 2008

References

  • Goldstein J. L., Anderson R. G.W., Brown M. S. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 1979; 279: 679–685
  • Anderson R. G.W., Goldstein J. L., Brown M. S. Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. Proc. Natl. Acad. Sci. USA 1976; 73: 2434–2438
  • Anderson R. G.W., Brown M. S., Goldstein J. L. Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts. Cell 1977; 10: 351–364
  • Orci L., Carpentier L. -J, Perrelet A., Anderson R. G.W., Goldstein J. L., Brown M. S. Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching. Exp. Cell Res. 1978; 113: 1–13
  • Goldstein J. L., Brown M. S. The low-density lipoprotein pathway and its relation to atherosclerosis. Ann. Rev. Biochem. 1977; 46: 897–930
  • Pearse B. M.F. Coated vesicles from pig brain: Purification and biochemical characterization. J. Mol. Biol. 1975; 97: 93–98
  • Anderson R. G.W., Vasile E., Mello R. J., Brown M. S., Goldstein J. L. Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: Relation to low density lipoprotein receptor distribution. Cell 1978; 15: 919–933
  • Brown M. S., Goldstein J. L. Receptor-mediated control of cholesterol metabolism. Science 1976; 191: 150–154
  • Goldstein J. L., Brown M. S. The LDL receptor locus and the genetics of familial hypercholesterolemia. Ann. Rev. Genet. 1979; 13: 259–289
  • Brown M. S., Goldstein J. L. Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein. Cell 1976; 9: 663–674
  • Goldstein J. L., Brown M. S. Genetics of the LDL receptor: Evidence that the mutations affecting binding and internalization are allelic. Cell 1977; 12: 629–641
  • Anderson R. G.W., Goldstein J. L., Brown M. S. A mutation that impairs the ability of lipoprotein receptors to localize in coated pits on the cell surface of human fibroblasts. Nature 1977; 270: 695–699
  • Carpentier J -L., Gorden P., Goldstein J. L., Anderson R. G.W., Brown M. S., Orci L. Binding and internalization of 125I-LDL in normal and mutant human fibroblasts: A quantitative autoradiographic study. Exp. Cell Res. 1979, In Press
  • Krieger M., Smith L. C., Anderson R. G.W., Goldstein J. L., Kao Y. J., Pownall H. J., Gotto A. M., Brown M. S. Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cells. J. Supra. Struct. 1979, In Press
  • Krieger M., Brown M. S., Faust J. R, Goldstein J. L. Replacement of endogenous cholesteryl esters of low density lipoprotein with endogenous cholesteryl linoleate: Reconstitution of a biologically active lipoprotein particle. J. Biol. Chem. 1978; 253: 4093–4101
  • Goldstein J. L., Basu S. K., Brunschede G. Y., Brown M. S. Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans. Cell 1976; 7: 85–95
  • Goldstein J. L., Brown M. S., Anderson R. G.W. The LDL pathway in human fibroblasts: Biochemical and ultrastructural correlations. International Cell Biology 1976–1977, B. R. Binkley, K. R. Porter. The Rockefeller University Press, New York 1977; 639–648
  • Goldstein J. L., Helgeson J. A.S., Brown M. S. Inhibition of cholesterol synthesis with compactin renders growth of mammalian cells dependent on the low density lipoprotein receptor. J. Biol. Chem. 1979; 254: 5403–5409
  • Maxfield F. R., Schlessinger J., Schecter Y., Paston I., Willingham M. C. Collection of insulin, EGF, and α-2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell 1978; 14: 805–810

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