5
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Human Lymphocytes as a Model for Beta-Adrenergic Receptors in Clinical Investigation

, &
Pages 71-88 | Published online: 26 Sep 2008

References

  • Williams L. T., Snyderman R., Lefkowitz R. Identification of beta-adrenergic receptors in human lymphocytes by (−) 3H-alprenolol binding. J. Clin. Invest. 1976; 57: 149–155
  • Motulsky H. J., Insel P. Adrenergic receptors in an, direct identification, physiologic regulation, and clinical alterations. N. Engl. J. Med. 1982; 307: 18–29
  • Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Cl in. Lab. Invest. 1968; 21(Suppl. 97)77–89
  • Bürgisser E., Hancock A. A., Lefkowitz R. J., De Lean A. Anomalous equilibrium binding properties of high-affinity racemic radioligands. Mol. Pharmacol. 1981; 19: 205–216
  • Landmann R., Bittiger H., Bühler F. High affinity beta-2-adrenergic receptors in mononuclear leucocytes: similar density in young and old normal subjects. Life Sci. 1981; 29: 1761–1771
  • Engel G., Hoyer D., Berthold R., Wagner H. (+) (125Iodo)cyanopindolol, a new radioligand for beta-adrenoceptors: Identification and quantitation of subclasses of beta-adrenoceptors in guinea pig, Naunyn Schmiedeberg's Arch. Pharmacol. 1981; 317: 277–285
  • Tee-Ping Lee, Szefler St., Ellis E. F. Beta-adrenergic receptors of human polymorphonuclear leucocytes. Res. Commun. Chem. Pathol. Pharmacol. 1981; 31: 453–461
  • Limbird Lee E., Gill D. M., Stadel J. M., Hickey A. R., Lefkowitz R. J. Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. J. Biol. Chem. 1980; 255: 1854–1861
  • Shane E., Gammon D. E., Bilezikian J. P. Guanine nucleotide induced shift in binding affinity for beta-adrenergic agonists in rat reticulocyte and turkey erythrocyte membranes. Biochem. Pharmacol. 1981; 30: 531–535
  • Lad P. M., Nielson T. B., Preston H. S., Rodbell M. The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes. J. Biol. Chem. 1980; 255: 988–995
  • Wolfe B. B., Harden T. K. Guanine nucleotides modulate the affinity of antagonists at adrenergic receptors. J. Cyclic Nucleotide Res. 1981; 7: 303–312
  • Schocken D. D., Roth G. S. Reduced adrenergic receptor concentrations in ageing man. Nature 1977; 267: 856–858
  • Abrass I. B., Scarpace J.Ph. Human lymphocyte beta-adrenergic receptors are unaltered with age. J. Gerontol. 1981; 36: 298–301
  • Doyle V. M., O'Malley K., Kelly J. G. Human Tymphocyte beta-adrenoceptor density in relation to age and hypertension. J. Cardiovasc. Pharmacol 1982, in press
  • Sprent J. Migration and lifespan of Tymphocytes. B and T cells in immune recognition, F. Loor, G. E. Roelants. Wiley and Sons, London 1977; 66–69
  • Makinodan T., Good R. T., Kay M. M.B. Cellular basis of immunosenescence. Comprehensive Immunology, Vol. 1, R. A. Good, St. B. Day. Plenum Medical Book company, New York 1977; 9–22
  • Bühler F. R., Kiowski W., Landmann R., vanBrummelen P., Amann F. W., Bolli P., Bertel O. Changing role of beta and alpha-adrenoceptor-mediated cardiovascular responses in the transition from a high cardiac output into a high peripheral resistance phase in essential hypertension. Frontiers in Hypertension Research, J. H. Laragh, F. R. Bühler, D. W. Seldin. Springer, New York 1981; 316–324

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.