Identification and Characterization of a Specific Receptor for Cholecystokinin on Isolated Fundic Glands from Guinea Pig Gastric Mucosa Using a Biologically Active ¹²⁵I-CCK-8 Probe

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• , The separation and isolation of pure populations of parietal and chief cells would permit a resolution of this question by direct binding studies. However, existing methodologies for these separations are generally complex and require long isolation times (35,36,37) that might affect cell viability. In addition, cell enrichments generally do not exceed 70 to 80% which could complicate the interpretation of radioligand binding data under certain circumstances. Nevertheless, we have concentrated on the gastric gland because it represents a basic functional unit within the intact gastric mucosa which can be isolated under relatively mild conditions and with retention of a high degree of responsiveness to chemical and peptide secretatogues
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