Differentiation of Alpha-Adrenergic Receptors Using Pharmacological Evaluation and Molecular Modeling of Selective Adrenergic Agents

References

• Ahlquist R. P. Study of adrenotropic receptors. Amer. J. Physiol. 1948; 153: 586–600
   PubMed Web of Science ®Google Scholar
• Lands A. M., Arnold A., McAuliff J. P., Luduena F. P., Brown T. G. Differentiation of receptor systems by sympathomimetic amines. Nature (London) 1967; 214: 597–598
   PubMed Web of Science ®Google Scholar
• Langer S. Z. Presynaptic regulation of catecholamine release. Biochemical Pharmacology 1974; 23: 1793–1800
   PubMed Web of Science ®Google Scholar
• Wikberg J. E.S. Pharmacological classification of adrenergic receptors in the guinea pig. Nature (London) 1978; 273: 164–166
   PubMed Web of Science ®Google Scholar
• Wood C. L., Arnett C. D., Clarke W. R., Tsai B. S., Lefkowitz R. J. Subclassification of alpha-adrenergic receptors by direct binding studies. Biochem. Pharmacol. 1979; 28: 1277–1282
   PubMed Web of Science ®Google Scholar
• Doxey J. C., Smith C. F.C., Walker J. M. Selectivity of blocking agents for pre- and postsynaptic alpha-adrenoceptors in the rat and dog. Br. J. Pharmacol. 1977; 60: 91–96
   PubMed Web of Science ®Google Scholar
• Kyncl J. J., Sonders R. C., Sperzel W. D., Winn M., Seely J. H. Terazosin. New Cardiovascular Drugs, A. Scriabine. Raven Press, New York, N.Y. 1986; 1–18
   Google Scholar
• Lefkowitz R. J., Hoffman B. B. Adrenergic Receptors. Advances in Cyclic Nucleotide Research 1980; 12: 37–47
   Google Scholar
• Williams L. T., Lefkowitz R. J. Receptor Binding Studies. Adrenergic Pharmacology. Raven Press, New York, N.Y. 1978
   Google Scholar
• DeBernardis J. F., Kerkman D. J., Winn M., Bush E. N., Arendsen D. L., McClellan W. J, Kyncl J. J., Basha F. Z. Conformationally defined adrenergic agents. 1. Design and synthesis of novel alpha-2 selective adrenergic agents: Electrostatic repulsion based conformational prototypes. J. Med. Chem. 1985; 28: 1398–1404
   PubMedGoogle Scholar
• DeBernardis J. F., Kyncl J. J., Basha F. Z., Arendsen D. L., Martin Y. C., Winn M., Kerkman D. J. Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: Biological effects at alpha-1 and alpha-2 adrenergic receptors. J. Med. Chem. 1986; 29: 463–467
   Google Scholar
• DeBernardis J. F., Winn M., Arendsen D. L., Kerkman D. J., Kyncl J. J. Conformationally defined adrenergic agents. 3. Modifications to the carbocyclic ring of 5,6-Dihydroxy-1-(2-imidazolinyl) tetralin: Improved separation of alpha-1 and alpha-2 adrenergic activities. J. Med. Chem. 1986; 29: 463–467
   Google Scholar
• DeBernardis J. F., Arendsen D. L., Kyncl J. J., Kerkman D. J. Conformationally defined adrenergic agents. 4. 1-(aminomethyl)phthalans: Synthesis and pharmacological consequences of the phthalan ring oxygen atom. J. Med. Chem. 1987; 30: 178–184
   Google Scholar
• DeBernardis J. F., Kerkman D. J., Arendsen D. L., Buckner S. A., Kyncl J. J., Hancock A. A. Conformationally defined adrenergic agents. 5. Resolution, absolute configuration and pharmacological characterization of the enantiomers of 2-(5,6 Dihydroxy-1,2,3,4-tetrahydro-1-naphthyl) imidazoline; a potent agonist at alpha-adrenoceptors. J. Med. Chem. 1987, (in press)
   Google Scholar
• Kerkman D. J., DeBernardis J. F., McClellan W. J., Basha F. Z., De B, Kyncl J. J., Buckner S. A. A new class of alpha-2 adrenergic agents. Amer. Chem. Soc. 1986; MEDI-16
   Google Scholar
• DeBernardis J. F., Kerkman D. J., McClellan W. J. Tetrahydrobenzo[e]isoindolines. U. S. Patent 4,618,683, Oct. 21, 1986
   Google Scholar
• Greengrass P., Bremner R. Binding characteristics of 3H-Prazosin to rat brain alpha-adrenergic receptors. Eur. J. Pharmacol. 1979; 55: 323–326
   PubMed Web of Science ®Google Scholar
• Perry B. D., U'Prichard D. C. [3H]-Rauwolscine (alphayohimbine): A specific antagonist radioligand for brain alpha-2 receptors. Europ. J. Pharmacol. 1981; 76: 461–464
   PubMedGoogle Scholar
• Hancock A. A., DeLean A. L., Lefkowitz R. J. Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: Application of a computerized model fitting technique. Mol. Pharm. 1979; 16: 1–9
   PubMed Web of Science ®Google Scholar
• Kyncl J. J., DeBernardis J. F., Bush E. N., Buckner S. A., Brondyk H. I. Novel adrenergic compounds. Receptor interactions of Abbott-54741 (5,6 dihydroxy-1,2,3,4-tetrahydro-1-naphthyl) imidazoline, an alpha-adrenergic agonist. J. Cardiovascular Pharm., (submitted)
   Google Scholar
• Pecherer B., Sunbury R. C., Brossi A. The synthesis of some 7- and 7,8-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines. J. Heterocyclic Chem. 1971; 8: 779–783
   Google Scholar
• Humblet C., Marshall G. R. Three-dimensional computer computer modeling as an aid to drug design. Drug Dev. Res. 1981; 1: 409–434
   Google Scholar
• Martin Y. C., Danaher E. A. Molecular modeling of receptor-ligand interactions. Receptor Pharmacology and Function, M. Williams, R. A. Glennon, P. B.M.W.M. Timmermans. Marcel Dekker Inc., New York, N.Y., (in press)
   Google Scholar
• Bovy P, DePrijck A., Durant F. Computer assisted investigation of structure activity relationship in alpha-2 adrenoceptor ligands. J. Molec. Graph. 1986; 4: 234
   Google Scholar