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Research Article

Probing the Receptor-Interaction of Glycoprotein Hormones with Monoclonal Antibodies

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Pages 437-453 | Published online: 26 Sep 2008

References

  • Catt K. J., Dufeau M., Tsuruhara T. Absence of intrinsic biological activity of LH and hCG subunits. J.Clin.Endocrinol.Metab. 1973; 36: 73–80
  • Boothby M., Ruddon R. W., Anderson C., McWilliams D., Boime I. A single gonadotropin alpha-subunit gene in normal tissue and tumor derived cell lines. J.Biol.Chem. 1981; 256: 5121–5127
  • Boorstein W. R., Vamvakopoulos N. C., Fiddes J. C. Human chorionic gonadotropin beta-subunit is encoded by at least eight genes arranged in tandem and inversed pairs. Nature 1982; 300: 419–422
  • Morgan F. J., Birken S., Canfield R. E. The amino acid sequence of human chorionic gonadotropin: The alpha-subunit and beta-subunit. J.Biol.Chem. 1975; 250: 5247–5258
  • Hussa R. O. Human chorionic gonadotropin, a clinical marker: Review of its biosynthesis. Ligand Rev. 1981; 3(Suppl.2)6–43
  • Vaitukaitis J. L., Ross G. T., Reichert L. E., Jr., Ward D. N. Immunologic basis for within and between species crossreactivity of luteinizing hormone. Endocrinology 1972; 91: 1337–1342
  • Pierce J. G., Bahl O. P., Cornell J. S., Swaminathan N. Biologically active hormones prepared by recombination of the alpha-chain of human chorionic gonadotropin and the hormone-specific chain of bovine thyrotropin or of bovine luteinizing hormone. J.Biol.Chem. 1971; 246: 2321–2324
  • Kofler R., Kalchschmid E., Berger P., Wick G. Production and characterization of monoclonal antibodies against bovine luteinizing hormone. Immunobiol. 1981; 160: 196–207
  • Kofler R., Berger P., Wick G. Monoclonal antibodies against human chorionic gonadotropin (hCG): I. Production, specificity and intramolecular binding sites. Am.J.Reprod.Immunol. 1982; 2: 212–216
  • Berger P., Kofler R., Wick G. Monoclonal antibodies against human chorionic gonadotropin (hCG): II. Affinity and ability to neutralize the biologic activity of hCG. Am.J.Reprod.Immunol. 1984; 5: 157–161
  • Berger P. Demonstration o the molecular morphology of placenta and pituitary hormones. Epitope mapping by means of monoclonal antibodies (MCA). Wiener Klin.Wschr. 1985; 97: 573–581
  • Schwarz S., Berger P., Wick G. The antigenic surface of human chorionic gonadotropin as mapped by murine monoclonal antibodies. Endocrinology 1986; 118: 189–197
  • Schwarz S., Berger P., Wick G. Epitope-selective monoclonal-antibody-based immunoradiometric assays of predictable specificity for differential measurement of chorionic gonadotropin and its subunits. Clin.Chem. 1985; 31: 1322–1328
  • Schwarz S. A simple computer program for Scatchard plot analysis of steroid receptors including non-specific binding correction on a low cost desk-top calculator. J.Steroid.Biochem. 1979; 11: 1641–1649
  • Hunter W. M., Greenwood F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature 1962; 194: 495–496
  • Novotny J., Bruccoleri R., Newell J., Murphy D., Haber E., Karplus M. Molecular anatomy of the antibody binding site. J.Biol.Chem. 1983; 258: 14433–14437
  • Berger P., Staindl B., Wick G. Antigenic features of human protein hormones elucidated by monoclonal antibodies. Strathclyde Bioengeneering Seminar, J. P. Paul. MacMillan Press, London 1987, in press
  • Kofler R. Immunofluorescence localization of glycoprotein hormones in the rat anterior pituitary using monoclonal antibodies and polyclonal antisera. J.Histochem.Cytochem. 1982; 30: 645–649
  • Bosch A. M.G., Schuurs A. H.W.M. Immunochemical and biological properties of monoclonal antibodies (MCAs) against human chorionic gonadotropin (hCG). Ann.d'Endocrinol. (Paris) 1984; 45: 343–351
  • Pierce J. G., Bloomfield G. A., Parsons T. F. Purification and receptor binding properties of complexes between lutropin and monovalent antibodies against its alpha subunit. Int.J.Pept.Prot.Res. 1979; 13: 54–61
  • Moyle W. R., Ehrlich P. H., Canfield R. E. Use of monoclonal antibodies to subunits of human chorionic gonadotropion to examine the orientation of the hormone in its complex with receptor. Proc.Natl.Acad.Sci.USA 1982; 79: 2245–2249
  • Ji I., Ji T. H. Both alpha- and beta-subunits of human chorionic gonadotropin photoaffinity label the hormone receptor. Proc.Natl.Acad.Sci.USA 1981; 78: 5465–5469
  • Milius R. P., Midgley A. R., Jr., Birken S. Preferential masking by the receptor of immunoreactive sites of the alpha-subunit of human chorionic gonadotropin. Proc.Natl.Acad.Sci.USA 1983; 80: 7375–7379
  • Hwang J., Menon K. M.J. Spatial relationship of the human chorionic gonadotrpin (hCG) subunbits in the assembly of the hCG-receptor complex in the luteinized rat ovary. Proc.Natl.Acad.Sci.USA 1984; 81: 4667–4671
  • Schwarz S., Berger P., Frisch H., Moncayo R., Phillips J. A., Jr., Wick G. Growth hormone blocking antibodies in a patient with deletion of the GH-N gene. Clin.Endocrinol. (Oxf.) 1987, in press
  • Talwar G. P., Ramakrishnan S., Das C., Dubey S. K., Salahuddin M., Shastri N., Tandon A., Singh O. M. Anti-hCG immunization, in Recent Advances in Reproduction and Regulation of Fertility, G. P. Talwar. Elsevier/North Holland Biomedical Press. 1979; 453
  • Berger P. A cautionary view of antifertility vaccines, Letter to the Editor. Nature 1987; 326: 648

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