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Research Article

The Dissociation Rate of Unlabelled Drugs from Receptor Sites: A Poorly Investigated, Yet Important Aspect in Receptor Research. Studies on the Serotonin-S2 Receptor

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Pages 547-559 | Published online: 26 Sep 2008

References

  • Leysen J. E., Gommeren W. The dissociation rate of unlabelled dopamine antagonists and agonists from the dopamine D2 receptor, application of an original filter method. J. Recept. Res. 1984; 4: 817–845
  • Leysen J. E., Gommeren W. Drug-receptor dissociation time, new tool for drug research: Receptor binding affinity and drug-receptor dissociation profiles of serotonin-S2, dopamine-D2, histamine-H1, antagonists, and opiates. Drug Dev. Res. 1986; 8: 119–131
  • Leysen J. E., Gommeren W., Van Gompel P., Wynants J., Janssen P. F.M., Laduron P. M. Receptor-binding properties in vitro and in vivo of ritanserin, a very potent and long acting serotonin-S2 antagonist. Mol. Pharmacol. 1985; 27: 600–611
  • Leysen J. E., Van Gompel P., Gommeren W., Woestenborghs R., Janssen P. A.J. Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the sero-tonin-S2 antagonists: Ritanserin and setoperone. Psycho-pharmacology 1986; 88: 434–444
  • De Chaffoy de Courcelles D., Leysen J. E., Roevens P., Van Belle H. The serotonin-S2 receptor. A receptor-transducer coupling model to explain insurmountable antagonist effects. Drug Dev. Res. 1986; 8: 173–178
  • Leysen J. E., Laduron P. M., Niemegeers C. J.E. Receptor binding properties in vivo and in vitro of new long acting narcotic analgesics. Characteristics and Function of Opioids, Van Ree, Terenius. Elsevier/North Holland Biomedical Press. 1978; 479–482
  • Leysen J. E., Niemegeers C. J.E., Van Nueten J. M., Laduron P. M. [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role. Mol. Pharmacol. 1982; 21: 301–314

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