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Research Article

GABAA-Receptors: Drug Binding Profile and Distribution of Receptors Containing the α2-Subunit in Situ

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Pages 467-477 | Published online: 26 Sep 2008

References

  • Benke D., Mertens S., Trceziak A., Gillessen D., Mohler H. GABAA-receptors: association of the γ2-subunit with the α1-subunit and the β2/3-subunits. J. Biol. Chem. 1991a; 266: 4478–4483
  • Benke D., Mertens S., Mohler H. Ubiquitous presence of GABAA receptors containing the α1-subunit in rat brain demonstrated by immunoprecipitation and immunohistochemistry. Mol. Neuropharmacol. 1991b; 1: 103–110
  • Duggan M. J., Pollard S., Stephenson A. F. Immunoaffinity purification of GABAA receptor α-subunit iso-oligomers. J. Biol. Chem. 1991; 266: 24778–24784
  • Fritschy J.-M., Benke D., Mertens S., Oertel W. H., Bachi T., Mohler H. Five subtypes of γ-aminobutyric acid type A receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc. Natl. Acad. Sci. USA 1992; 89: 6726–6730
  • Khrestchatisky M., MacLennan A. J., Tillakaratne N. J. K., Chiang M.-Y., Tobin A. J. Sequence and regional distribution of the mRNA encoding the α2 polypeptide of rat γ-aminobutyric acidA receptors. J. Neurochem. 1991; 56: 1717–1722
  • Laurie D. J., Seeburg P. H., Wisden W. The distribution of 13 GABAA receptor subunit mRNA in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci. 1992; 12: 1063–1076
  • McKernan R. M., Quirk K., Prince R., Cox P. A., Gillard N. P., Ragan C. I., Whiting P. GABAA receptor subtypes immunopurified from rat brain with α subunit-specific antibodies have unique pharmacological properties. Neuron 1991; 7: 667–676
  • Mertens S., Benke D., Mohler H. GABAA receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5- and δ-subunit-specific immunopurification. 1992, in preparation
  • Mohler H., Burkard W. P., Keller H. H., Richards J. G., Haefely W. Benzodiazepine antagonist Ro 15–1788: Binding characteristics and interaction with drug induced changes in dopamine turnover and cerebellar cGMP levels. J. Neurochem. 1981; 37: 714–722
  • Mohler H., Malherbe P., Draguhn A., Richards J. GABAA receptors: structural requirements and sites of gene expression in mammalian brain. Neurochem. Res. 1990; 15: 199–207
  • McPherson G. A. Analysis of radioligand binding experiments: A collection of computer programs for the IBM PC. J. Pharmacol. Methods 1985; 14: 213–228
  • Persohn E., Malherbe P., Richards J. G. Comparative molecular neuroanatomy of cloned GABAA receptor subunits in the rat CNS. J. Comp. Neurol. 1992, in press
  • Pollard S., Duggan M. J., Stephenson F. A. Promiscuity of GABAA-receptor β3 subunits as demonstrated by their presence in α1, α2 and α3 subunit containing receptor subpopulations. FEBS Lett. 1991; 295: 81–83
  • Pritchett D., Seeburg P. H. γ-Aminobutyric acidA receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 1990; 54: 1802–1804
  • Pritchett D., Lüddens H., Seeburg P. H. Type I and type II GABAA-benzodiazepine receptors produced in transfected cells. Science 1989; 245: 1389–1392
  • Wisden W., Seeburg P. H. GABAA receptor channels: from subunits to functional entities. Curr. Op. Neurobiol. 1992; 2: 263–269
  • Wisden W., Laurie D. J., Monyer H., Seeburg P. H. The distribution of 13 GABAA receptor subunits mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 1992; 12: 1040–1062
  • Zezula J., Sieghart W. Isolation of type I and type II GABAA-benzodiazepine receptors by immunoaffinity chromatography. FEBS Lett. 1991; 284: 15–18
  • Zimprich F., Zezula J., Sieghart W., Lassmann H. Immunohistochemical localization of the α1, α2, and α3 subunit of the GABAA receptor in the rat brain. Neurosci. Lett. 1991; 127: 125–128

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