3
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Receptor Interactions of Abbott-81988, A Highly Potent, Non-Peptide Angiotensin-II Antagonist Selective for Type-1 Receptors

, , , , , , , , , , & show all
Pages 229-249 | Published online: 26 Sep 2008

References

  • Pals D. T., Masucci F. D., Denning G. S., Jr., Sipos F., Fessler D. C. Role of the pressor action of angiotensin II in experimental hypertension. Circ. Res. 1971; 29: 673–681
  • Nishikawa K., Shibouta Y., Inada Y., Terashita Z., Kawazoe K., Furukawa Y. Nonpeptide angiotensin II receptor antagonists: pharmacological studies on imidazoleacetic acid derivatives. J. Takeda Res. Lab 1991; 50: 75–98
  • Wong P. C., Chiu A. T., Duncia J. V., Herblin W. F., Smith R. D., Timmermans P. B. M. W. M. Angiotensin II receptor antagonists and receptor subtypes. Trends in Endocrin. Metab. 1992; 3: 211–217
  • Song K., Zhuo J., Allen A. M., Paxinos G., Mendelsohn F. A. O. Angiotensin‐II receptor subtypes in rat brain and peripheral tissues. Cardiology 1992; 79(Suppl 1)45–54
  • Bumpus F. M., Catt K. J., Chiu A. T., Degasparo M., Goodfriend T., Husain A., Peach M. J., Taylor D. G., Jr., Timmermans P. B. M. W. M. Nomenclature for angiotensin receptors: a report of the nomenclature committee of the council for high blood pressure research. Hypertension 1992; 17: 720–721
  • De B., Winn M., Zydowsky T. M., Kerkman D. J., DeBernardis J. F., Lee J., Buckner S., Warner R., Brune M., Hancock A., Opgenorth T., Marsh K. Discovery of a novel class of orally active, nonpeptide angiotensin‐II antagonists. J. Med. Chem. 1992; 35: 3714–3717
  • Chiu A. T., Carini D. J., Johnson A. L., McCall D. E., Price W. A., Thoolen M. J. M. C., Wong P. C., Taber R. I., Timmermans P. B. M. W. M. Non‐peptide angiotensin‐II receptor antagonists. II. Pharmacology of S‐8308. Eur. J. Pharmacol. 1988; 157: 13–21
  • DeLean A., Munson P. J., Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose‐response curves. Am. J. Physiol. 1980; 235: E97–E102
  • Schild H. O. pA, A new scale for the measurement of drug antagonism. Br. J. Pharmacol. 1947; 2: 189–206
  • Fluharty S. J., Reagen L. P. Characterization of binding sites for the angiotensin II antagonist 125l‐[SARC1ILE8]‐angiotensin II on murine neuroblastoma N1E‐115 cells. J. Neurochem. 1989; 52: 1393–1400
  • Neville D. M., Jr. Isolation of an organ specific protein antigen from cell‐surface membrane of rat liver. Biochem. Biophys. Acta. 1968; 154: 540–552
  • DeBernardis J. F., Kerkman D. J., Winn M., Bush E. N., Arendsen D. L., McClellan W. J., Kyncl J. J., Basha F. Z. Conformationally defined adrenergic agents. 1, Design and synthesis of novel alpha‐2 selective adrenergic agents: Electrostatic repulsion based conformation prototypes. J. Med. Chem. 1985; 28: 1398–1404
  • Hancock A. A., Delean A. L., Lefkowitz R. J. Quantitative resolution of beta‐adrenergic subtypes by selective ligand binding: application of a computer model‐fitting technique. Mol. Pharmacol. 1979; 16: 1–9
  • DeLean A. L., Ong H., Gutkowska J., Schiller P. W., McNicoll N. Evidence for agonist‐induced interaction of angiotensin receptor with a guanine nucleotide‐binding protein in bovine adrenal zona glomerulosa. Mol. Pharmacol. 1984; 26: 498–508
  • Gangiano J. L., Rodriguez‐Sargent C., Martinez‐Maldonado M. Effects of antihypertensive treatment on systolic blood pressure and renin in experimental hypertension in rats. J. Pharmacol. Exp. Ther. 1979; 208: 310–313
  • Wong P. C., Price W. A., Chiu A. T., Duncia J. V., Carini D. J., Wexler R. R., Johnson A. L., Timmermans P. B. M. W. M. Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 1990; 252: 726–732
  • Scanlon M. N., Moore G. J. Classification of angiotensin receptors in rat isolated uterus, portal vein, and aorta using a slowly dissociating antagonist [Sar1 lle8]ANG II for receptor blockade, J. Pharmacol. Meth. 1988; 20: 207–224
  • Hancock A. A., Buckner S. A., Lee J. Y., Brune M., Morse P. A., Oheim K., Warner R. B., Winn M., Zydowsky T. M., De B., Kerkman D. J., DeBernardis J. F. Pharmacological characterization of Abbott‐81282, a novel, non‐peptide angiotensin‐II antagonist selective for type‐1 receptors. Life Sciences 1993; 53: 929–937
  • Wong P. C., Price W. A., Jr., Chiu A. T., Duncia J. V., Carini D. J., Wexler R. R., Johnson A. L., Timmermans P. B. M. W. M. Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: An active metabolite of DuP 753, an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 1990; 255: 211–217
  • Chang R. S. L., Siegl P. K. S., Clineschmidt B. V., Mantlo N. B., Chakravarty P. K., Greenlee W. J., Patchett A. A., Lotti V. J. In vitro pharmacology of L‐158,809, a highly potent and selective angiotensin II receptor antagonist. J. Pharm. Exp. Ther. 1992; 262: 133–138
  • Chiu A. T., McCall D. E., Price W. A., Wong P. C., Carini D. J., Duncia J. V., Wexler R. R., Yoo S. E., Johnson A. L., Timmermans P. B. M. W. M. Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent. J. Pharm. Exp. Ther. 1990; 252: 711–718
  • Van Rossum J. Cumulative dose‐response curves. II. Technique for the making of dose‐response curves in isolated organs and the evaluation of drug parameters. Arch. Int. Pharmacodyn. Ther. 1963; 143: 299–330
  • Hancock A. A., Surber B., Rotert G., Thomas S., Tasker A., Sorensen B., Vodenlich A., Opgenorth T., Kerkman D., DeBernardis J. F. [3H]‐A‐81988, A potent, selective, competitive antagonist radioligand for angiotensin‐II type 1 receptors (AT1 R). The FASEB Journal 1993; 7: A246
  • Casteilion A. W., Fulton R. W. Preclinical pharmacology of saralasin. Kidney International 1979; 15: S11–S19
  • Oheim K., Morse P., Buckner S. A., Milicic I., Hancock A. A., Lee J. Y., Marsh K. C., Bauch J., Winn M., De B., Zydowsky T. M., Kerkman D. J., DeBernardis J. F. Abbott(A)‐81988: A potent, competitive nonpeptide antagonist at the angiotensin‐II‐1 Receptor (AT1R) with advantageous pharmacokinetics. FASEB Journal 1993; 7: A245
  • Brune M. E., Lee J. Y., Warner R. B., Winn M., De B., Zydowsky T. M., Opgenorth T. J., Kerkman D. J., DeBernardis J. F. Abbott (A)‐81988, a nonpeptide angiotensin II (All) antagonist: Comparative antihypertensive effects in renal artery‐ligated (RAL) rat and safety profile. FASEB J. 1993; 7: A246
  • Winn M., De B., Zydowsky T. M., Altenbach R., Basha F., Boyd S., Brune M., Buckner S., Crowell D., Drizin I., Hancock A., Jae H. S., Kester J., Lee J., Mantei R., Marsh K., Novosad E., Oheim K., Rosenberg S., Shiosaki K., Sorensen B., Spina K., Sullivan G., Tasker A., von Geldern T., Warner R., Opgenorth T., Kerkman D., DeBernardis J. 2‐Alkylamino nicotinic acid and analogs–potent angiotensin II antagonists. J. Med Chem. 1993; 36: 2676–2688

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.