92
Views
39
CrossRef citations to date
0
Altmetric
Research Article

The Pharmacology of the Benzodiazepine Site of the GABA-A Receptor is Dependent on the Type of γ-Subunit Present

, , , , , & show all
Pages 173-183 | Published online: 26 Sep 2008

References

  • Olsen R. W., Tobin A. J. Molecular biology of GABAA receptors. FASEB J. 1990; 4: 1469–1480
  • Burt D. A., Kamatchi G. L. GABA-A receptor subtypes: from pharmacology to molecular biology. FASEB J. 1991; 5: 2916–2923
  • Pritchett D. B., Lüddens H., Seeburg P. H. Type I and type II GABAA benzodiazepine receptors produced in transfected cells. Science 1989; 245: 1389–1392
  • Pritchett D. B., Seeburg P. H. γ-Aminobutyric acidA receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 1992; 54: 1802–1804
  • Luddens H., Pritchett D. B., Kohler M., Killisch I., Keinanen K., Monyer H., Sprengel R., Seeburg P. H. Cerebellar GABAA receptor selective for a behaviour alcohol antagonist. Nature 1990; 346: 648–651
  • Wisden W., Herb A., Wieland H., Keinanen K., Lüddens H., Seeberg P. H. Cloning, pharmacological characteristics and expression pattern of rat GABAA receptor α4 subunit. FEBS 1991; 289: 227–230
  • Wieland H. A., Lüddens H., Seeburg P. H. A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 1992; 267(3)1426–1429
  • Hadingham K. L., Wingrove P. B., Wafford K. A., Bain C., Kemp J. A., Palmer K. J., Wilson A. W., Wilcox A. S., Sikela J. M., Ragan C. I., Whiting P. J. The role of the beta subunit in determining the pharmacology of human GABAA receptors. Mal. Pharmacol. 1993; 44: 1211–1218
  • Ymer S., Draguhn A., Wisden W., Werner P., Keinanen K., Schofield P. R., Sprengel R., Pritchett D. B., Seeburg P. H. Structural and functional characterization of the γ1 subunit of GABAA/benzodiazepine receptors. EMBO J. 1990; 9: 3261–3267
  • Pritchett D. B., Sontheimer H., Shivers B. D., Ymer S., Kettersmann H., Schofield P. R., Seeburg P. H. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature 1989; 338: 582–585
  • Herb A., Wisden W., Lüddens H., Puia G., Vicini S., Seeburg P. H. The third γ subunit of the γ-aminobutyric acid type A receptor family. Proc. Natl. Acad. Sci. 1992; 89: 1433–1437
  • Knoflach F., Rhyner T., Villa M., Kellenbergen S., Drescher U., Malherbe P., Sigel E., Mohler H. The γ3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands. FEBS Lett. 1991; 293(1-2)191–4
  • McKernan R. M., Quirk K., Prince R., Cox P. A., Gillard N. P., Ragan C. I., Whiting P. J. GABAA receptors immunopurified from rat brain with a subunit-specific antibodies have unique pharmacological properties. Neuron 1991; 7: 667–676
  • Quirk K., Gillard N. P., Ragan C. I., Whiting P. J., McKernan R. M. GABAA receptors in the rat brain can contain both γ2 and γ3 subunits, but γ1 does not exist in combination with another γ-subunit. Mol. Pharmacol, (in press)
  • Wafford K. A., Bain C. J., Whiting P. J., Kemp J. A. Functional comparison of the role of γ-subunits in recombinant human γ-aminobutyric Acid/benzodiazepine receptors. Mol Pharmacol 1993; 44: 437–442
  • Sigel E., Baur R. Allosteric modulation by benzodiazepine receptor ligands of the GABAA receptor channel expressed in xenopus oocytes J. Neurosci 1988; 8: 289–295
  • Sigel E., Baur R., Trube G., Mohler H., Malherbe P. The effects of subunit composition of rat brain GABAA Receptor on receptor function. Neuron 1990; 5: 703–711

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.