56
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Functional Characterization of the Human Neurokinin Receptors NK1, NK2, and NK3 Based on a Cellular Assay System

, , , , , , , & show all
Pages 617-630 | Published online: 26 Sep 2008

References

  • Eglezos A., Andrews P. V., Boyd R. L., Helme R. D. Modulation of the immune response by tachykinins. Immunol. Cell Biol. 1991; 69: 285–294
  • Otsuka M., Yoshioka K. Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 1993; 73: 229–308
  • Frossard N., Advenier C. Tachykinin receptors and the airways. Life Sci. 1991; 49: 1941–1953
  • Takano Y., Kamiya H. Tachykinin receptor subtypes: cardiovascular roles of tachykinin peptides. Asia Pac. J. Pharmacol. 1991; 6: 341–348
  • Mussap C. J., Geraghty D. P., Burcher E. Tachykinin receptors: a radioligand binding perspective. J. Neurochem. 1993; 60: 1987–2009
  • Gerard N. P., Bao L., Xiao-Ping H., Gerard C. Molecular aspects of the tachykinin receptors. Regulatory Peptides 1993; 43: 21–35
  • Mitsuhashi M., Ohashi Y., Shichijo S., Christian C., Sudduth-Klinger J., Harrowe G., Payan D. G. Multiple intracellular signalling pathways of the neuropeptide substance P receptor. J. Neurosci. Res. 1992; 32: 437–443
  • Eistetter H. R., Church D. J., Mills A., Godfrey P. P., Capponi A. M., Brewster R., Schulz M.-F., Kawashima E., Arkinstall S. J. Recombinant bovine neurokinin-2 receptor stably expressed in Chinese hamster ovary cells couples to multiple signal transduction pathways. Cell Regulation 1991; 2: 767–779
  • Eistetter H. R., Mills A., Arkinstall S. J. Signal transduction mechanisms of recombinant bovine neurokinin-2 receptor stably expressed in Baby hamster kidney cells. J. Cell. Biochem. 1993; 52: 84–91
  • Ingi T., Kitajima Y., Minamitake Y., Nakanishi S. Characterization of ligand-binding properties and selectivities of three rat tachykinin receptors by transfection and functional expression of their cloned cDNAs in mammalian cells. J. Pharmacol. Exp. Therapeut. 1991; 259: 968–975
  • Gether U., Marray T., Schwartz T. W., Johansen T. E. Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells. FEBS Left. 1992; 296: 241–244
  • De Wet J. R., Wood K. V., DeLuca M., Helinsky D. R., Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 1987; 7: 725–737
  • Himmler A., Stratowa C., Czernilofsky A. P. Functional testing of human dopamine D1 and D5 receptors expressed in stable cAMP-responsive luciferase reporter cell lines. J. Receptor Res. 1993; 13: 79–94
  • Weyer U., Schäfer R., Himmler A., Mayer S. K., Bürger E., Czernilofsky A. P., Stratowa C. Establishment of a cellular assay system for G protein-linked receptors: coupling of human NK2 and 5-HT2 receptors to phospholipase C activates a luciferase reporter gene. Receptors & Channels 1993; 1: 193–200
  • Gerard N. P., Garraway L. A., Eddy R. L., Jr., Shows T. B., Iijima H., Paquet J.-L., Gerard C. Human substance P receptor (NK-1): organization of the gene. chromosome localization, and functional expression of cDNA clones. Biochemistry 1991; 30: 10640–10646
  • Shigemoto R., Yokota Y., Tsuchida K., Nakanishi S. Cloning and expression of a rat neuromedin K receptor cDNA. J. Biol. Chem. 1990; 265: 623–628
  • Takahashi K., Tanaka A., Nara M., Nakanishi S. The primary structure and gene organization of human substance P and neuromedin K receptors. Eur. J. Biochem. 1992; 204: 1025–1033
  • Huang R.-R.C., Cheung A. H., Mazina K. E., Strader C. D., Fong T. M. cDNA sequence and heterologous expression of the human neurokinin-3 receptor. Biochem. Biophys. Res. Commun. 1992; 184: 966–972
  • Brasier A. R., Tate J. E., Habener J. F. Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Bio-Techniques 1989; 7: 1116–1121
  • Desai M. C., Thadeio P. F., Lefkowitz S. L. Synthesis of (±)-CP-99,994: a highly potent substance P antagonist. Tetrahedr. Lett. 1993; 34: 5831–5834
  • Piedimonte G., Bertrand C., Geppetti P., Snider R. M., Desai M. C., Nadel J. A. A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline. J. Pharmacol. Exp. Ther. 1993; 266: 270–273
  • Emonds-Alt X., Vilain P., Goulaouic P., Proietto V., Van Broeck D., Advenier C., Naline E., Neliat G., Le Fur G., Brelière J. C. A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life Sci. 1992; 50: PL–101; PL–106
  • Advenier C., Rouissi N., Nguyen Q. T., Emonds-Alt X., Brelière J. C., Neliat G., Naline E., Regoli D. Neurokinin A (NK2) receptor revisited with SR 48968. a potent non-peptide antagonist. Biochem. Biophys. Res. Commun. 1992; 184: 1418–1424
  • Giuliani S., Patacchini R., Giachetti A., Maggi C. A. In vivo and in vitro activity of SR 48,968. a non-peptide tachykinin NK-2 receptor antagonist. Regulatory Peptides 1993; 46: 314–316
  • Jacobi H. I., Lopez I., Wright D., Vaught J. L. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986; 39: 1995–2003
  • Sachais B. S., Snider R. M., Lowe J. A., III, Krause J. E. Molecular basis for the species selectivity of the substance P antagonist CP-96,345. J. Biol. Chem. 1993; 268: 2319–2323
  • Fong T. M., Yu H., Strader C. D. Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. J. Biol. Chem. 1992; 267: 25668–25671
  • Maggi C. A., Patacchini R., Astolfi M., Rovero P., Giachetti A., van Giersbergen P. L. M. Affinity of R369. an NK-2 tachykinin receptor antagonist, for NK-2 receptors in preparations from different species. Neuropetides 1992; 22: 93–98
  • Petitet F., Beaujouan J.-C., Saffroy M., Torrens Y., Glowinsky J. The nonpeptide NK-2 antagonist SR 48968 is also a NK-3 antagonist in the guinea pig but not in the rat. Biochem. Biophys. Res. Commun. 1993; 191: 180–187

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.