Diazepam biphasically modulates [³H]TBOB binding to the convulsant site of the GABA_A receptor complex

References

• Sivilotti L., Nistri A. GABA receptor mechanisms in the central nervous system. Progress in Neurobiology 1991; 36: 35–92
   PubMed Web of Science ®Google Scholar
• Sieghart W. GABAA receptors: ligand-gated Clion channels modulated by multiple drug-binding sites. Trends Pharmacol. Sci. 1992; 13: 446–450
   PubMed Web of Science ®Google Scholar
• Haefely W. E., Polc P., Pieri L., Schaffner R., Laurent J. P. Neuropharmacology of Benzodiazepines: Synaptic Mechanisms and neural Basis of Action, article. The benzodiazepines, From molecular biology to clinical practice, E. Costa. Raven Press, NY 1983; 21–67
   Google Scholar
• Haefely W. E. The GABAA-benzodiazepine receptor: biology and pharmacology, article. The Neurobiology of Anxiety, M. Roth, R. Noyes. Elsevier, Amsterdam 1990; 165–188
   Google Scholar
• Maksay G. GABAA Receptor Populations Bind Agonist and Antagonists Differentially and with Opposite Affinities. J. Neurochem. 1988; 50: 1865–1871
   Google Scholar
• Skerritt J. H., Willow M., Johnston G. A.R. Diazepam enhancement of low affinity GABA binding to rat brain membranes. Neurosci. Lett. 1982; 29: 63–66
   PubMed Web of Science ®Google Scholar
• Maksay G., Simonyi M. Kinetic Regulation of Convulsant (TBPS) Binding by GABAergic Agents. Mol. Pharmac. 1986; 30: 321–328
   Google Scholar
• Maksay G., Ticku M. K. GABA, Depressants and Chloride Ions Affect the Rate of Dissociation of 35S-t-Butylbicyclophosphonothionate Binding. Life Sci. 1985; 37: 2173–2180
   Google Scholar
• Trullas R., Havoundjian H., Scolnick P. Stress inducedchanges in t-[35S]Butylbicyclophosphorothionate binding to the gamma-Aminobutyric Acid Gated Chloride Channels are mimicked by in vitro occupancy of benzodiazepine receptors. J. Neurochem. 1987; 49: 968–974
   Google Scholar
• Wood P. L., Loo P., Braunwalder A., Yokoyama N., Cheney D. L. In vitro characterization of benzodiazepine agonists, antagonists and inverse agonists and agonistlantagonists. J.Pharmacol. Exp. Ther. 1984; 231: 572–576
   Google Scholar
• Gee K. W., Lawrence L. J., Yamamura H. I. Modulation of the Chloride Ionophore by Benzodiazepine Receptor Ligands: Influence of gamma-Aminobutyric Acid and Ligand Efficacy. Mol. Pharmacol. 1986; 30: 218–225
   Google Scholar
• VanRijn C. M., Willems-van Bree E., Van der Velden T. J. A. M., Rodrigues de Miranda J. F. The binding of the cage convulsant [3H]TBOB to sites linked to the GABAA receptor complex. Eur. J. Pharmacol. 1990; 179: 419–425
   Google Scholar
• Martini C., Pacini R., Giannaccini G., Lucacchini A. [35S]TBPS binding to purified benzodiazepine-GABA-ionophore receptor complex: the effect of GABA on the modulation exerted by benzodiazepine site ligands. Neurochem. Int. 1989; 15: 377–379
   Google Scholar
• Maksay G., Simonyi M. Benzodiazepine Anticonvulsants Accelerate and ß-Carboline Convulsants Decelerate the Kinetics of [35S]TBPS Binding at the Chloride Ionophore. Eur. J. Pharmacol. 1985; 117: 275–278
   Google Scholar
• Maksay G., Simonyi M. Nonequilibrium modulation of [35S]TBPS Binding by Benzodiazepine agonists and antagonists. Biochem, Pharmacol. 1988; 37: 2195–2200
   Google Scholar
• Braestrup C., Squires R. F. Pharmacological Characterization of Benzodiazepine Receptors in the Brain. Eur. J. Pharmacol. 1978; 48: 263–270
   PubMedGoogle Scholar
• Chiu T. H., Rosenberg H. C. GABA Receptor-mediated Modulation of 3H-diazepam Binding in Rat Cortex. Eur. J. Pharmacol. 1979; 56: 337–354
   PubMed Web of Science ®Google Scholar
• Supavilai P., Karobath M. Differential Modulation of 35S-TBPS Binding by the Occupancy of Benzodiazepine Receptors with its Ligands. Eur. J. Pharmacol. 1983; 91: 145–146
   Google Scholar
• Ticku M. K., Ramanjaneyulu R. Differential interactions of GABA agonists, depressant and convulsant drugs with [35S]-t-Butylbicyclophosphorothionate binding sites in cortex and cerebellum. Pharmac. Biochem. Behavior 1984; 21: 151–158
   Google Scholar
• Lawrence L. J., Palmer C. J., Gee K. W., Wang X., Yamamura H. I., Casida J. E. t-[3H]-Butylbicycloorthobenzoate: new radioligand probe for gamma-Aminobutyric acid-regulated chloride Ionophore. J. Neurochem. 1985; 45: 798–804
   PubMed Web of Science ®Google Scholar
• Gerrits G. P., Trijbels F. J., Monnens L. A., Gabreëls F. J., DeAbreu R. A., Theeuwens A. G., VanRaay-Selten B. Reference values for amino acids in cerebrospinal fluid of children determined using ion-exchange chromatography with fluorimetric detection. Clinica Chimica Acta 1989; 182: 271–280
   PubMed Web of Science ®Google Scholar
• Havoundjian H., Paul S. M., Scolnick P. The Permeability of gamma-Aminobutyric Acid Gated Chloride Channels is Described by the Binding of a Cage Convulsant t-Butylbicyclophosphoro[35S]thionate. Proc. Natl. Acad. Sci. 1986; 83: 9241–9244
   Google Scholar
• Squires R. F., Casida J. E., Richardson M., Saederup E. [35S]t-Butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to Gamma-Aminobutyric acid-A and ion recognition sites. Mol. Pharmacol. 1983; 23: 326–336
   PubMed Web of Science ®Google Scholar
• Olsen R. W., Snowman A. M. [3H]Bicuculline methochloride binding to gamma-aminobutyric acid receptor sites. J. Neurochem. 1983; 41: 1653–1663
   PubMed Web of Science ®Google Scholar
• Arians E. J., Beld A. J., Rodrigues de Miranda J. F., Simonis A. M. The pharmacon-receptor-effector concept. The receptors, A comprehensive treatise, R. D. O'Brien. Plenum Press, NY 1979; 33–91
   Google Scholar
• Wha Bin Im, Blakeman D. P. Correlation between gamma-Aminobutyric AcidA receptor ligand induced changes in t-Butylbicyclophosphoro[35S]thionate binding and 36C1−uptake in rat cerebrocortical membranes. Mot. Pharmacol. 1990; 39: 394–398
   Google Scholar
• Bowling A. C., DeLorenzo R. J. Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system. Science 1982; 216: 1247–1250
   PubMedGoogle Scholar
• Gee K. W. Phenylquinolines PK 8165 and PK 9084 allosterically modulate [35S]t-Butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro 5-4864 binding site. J. Pharmacol. Exp. Ther. 1987; 240: 747–753
   Google Scholar
• DeLorenzo R. J. A molecular approach to the calcium signal in brain: relationship to synaptic modulation and seizure discharge. Adv. Neurol. 1986; 44: 435–464
   PubMedGoogle Scholar
• Ticku M. K., Ramanjaneyulu R. Ro 5-4864 inhibits the binding of [35S]t-Butylbicyclophosphorothionate to rat brain membranes. Life Sci. 1984; 34: 631–638
   PubMed Web of Science ®Google Scholar
• VanRijn C. M., Willems-van Bree E., Dirksen R., Rodrigues de Miranda J. F. The GABAA receptor complex in relation to Epilepsy: Reversal of TBOB inhibition a prediction of disinhibitory, thus proconvulsive, properties?. Epilepsy Res. 1992; 12: 163–170
   Google Scholar
• Rastogi S. K., Ticku M. K. A possible role of a GABAergic mechanism in the convulsant action of Ro 5-4864. Pharmacol. Biochem. Behavior 1985; 23: 285–288
   PubMed Web of Science ®Google Scholar
• Möhler H., Richards J. G. Agonist and antagonist benzodiazepine receptor interaction in vitro. Nature 1981; 294: 763–765
   PubMed Web of Science ®Google Scholar
• Polc P. Electrophysiology of Benzodiazepine receptor ligands: Multiple mechanisms and sites of action. Progress in Neurobiology 1988; 31: 349–423
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Sethy V. H. Benzodiazepine concentrations in brain directly reflect receptor occupancy: studies of diazepam. lorazepam and oxazepam, Psychopharmacology 1990; 102: 373–378
   PubMed Web of Science ®Google Scholar
• Hoogerkamp A. Pharmacokinetic-pharmacodynamic modelling of the flumazenilmidazolam interaction in an animal model of epilepsy. Pharmacokinetic-Pharmacodynamic relationships of Anti-epileptic Drugs, 1992, Thesis by A. Hoogerkamp. Center for Bio-Pharmaceutical Sciences, Leiden University, The Netherlands, 139–154
   Google Scholar