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Research Article

The Role of Receptor Kinase Activity and the Npey960 Motif in Insulin-Accelerated Receptor-Mediated Insulin Internalization

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Pages 339-355 | Published online: 26 Sep 2008

References

  • Backer JM, Kahn CR, Cahill DA, Ullrich A, White MF. Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor β-subunit. J Biol Chem 1990; 265: 16450–16454
  • Backer JM, Schroeder GG, Cahill DA, Ullrich A, Siddle K, White MF. Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells. Biochem 1991; 30: 6366–6372
  • Backer JM, Shoelson SE, McClain D. Insulin receptor kinase activation release a constraint maintaining the receptor on microvilli. J Biol Chem 1995; 270: 5001–5006
  • Kaburagi Y, Momomura K, Yamamoto-Honda R, Tobe K, Tamori Y, Sakura H, Akanuma Y, Yazaki Y, Kadowski T. Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. J Biol Chem 1993; 268: 126610–16622

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